Mechanisms of antimicrobial resistance (AMR) and alternative approaches to overcome AMR
Antimicrobials are useful compounds intended to eradicate or stop the growth of harmful microorganisms. The sustained increase in the rates of antimicrobial resistance (AMR) worldwide is worrying and poses a major public health threat. The development of new antimicrobial agents is one of the critic...
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| Format: | Article |
| Language: | English |
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Bentham Science Publishers
2020
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| Online Access: | http://psasir.upm.edu.my/id/eprint/86706/ http://psasir.upm.edu.my/id/eprint/86706/1/Mechanisms%20of%20antimicrobial%20resistance%20.pdf |
| _version_ | 1848860267960598528 |
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| author | Moo, Chew Li Yang, Shun Kai Yusoff, Khatijah Ajat, Mokrish Warren, Thomas Abushelaibi, Aisha Lim, Swee Hua Erin Lai, Kok Song |
| author_facet | Moo, Chew Li Yang, Shun Kai Yusoff, Khatijah Ajat, Mokrish Warren, Thomas Abushelaibi, Aisha Lim, Swee Hua Erin Lai, Kok Song |
| author_sort | Moo, Chew Li |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Antimicrobials are useful compounds intended to eradicate or stop the growth of harmful microorganisms. The sustained increase in the rates of antimicrobial resistance (AMR) worldwide is worrying and poses a major public health threat. The development of new antimicrobial agents is one of the critical approaches to overcome AMR. However, in the race towards developing alternative approaches to combat AMR, it appears that the scientific community is falling behind when pitched against the evolutionary capacity of multi-drug resistant (MDR) bacteria. Although the “pioneering strategy” of discovering completely new drugs is a rational approach, the time and effort taken are considerable, the process of drug development could instead be expedited if efforts were concentrated on enhancing the efficacy of existing antimicrobials through: combination therapies; bacteriophage therapy; antimicrobial adjuvants therapy or the application of nanotechnology. This review will briefly detail the causes and mechanisms of AMR as background, and then provide insights into a novel, future emerging or evolving strategies that are currently being evaluated and which may be developed in the future to tackle the progression of AMR. |
| first_indexed | 2025-11-15T12:42:32Z |
| format | Article |
| id | upm-86706 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T12:42:32Z |
| publishDate | 2020 |
| publisher | Bentham Science Publishers |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-867062021-11-09T07:44:10Z http://psasir.upm.edu.my/id/eprint/86706/ Mechanisms of antimicrobial resistance (AMR) and alternative approaches to overcome AMR Moo, Chew Li Yang, Shun Kai Yusoff, Khatijah Ajat, Mokrish Warren, Thomas Abushelaibi, Aisha Lim, Swee Hua Erin Lai, Kok Song Antimicrobials are useful compounds intended to eradicate or stop the growth of harmful microorganisms. The sustained increase in the rates of antimicrobial resistance (AMR) worldwide is worrying and poses a major public health threat. The development of new antimicrobial agents is one of the critical approaches to overcome AMR. However, in the race towards developing alternative approaches to combat AMR, it appears that the scientific community is falling behind when pitched against the evolutionary capacity of multi-drug resistant (MDR) bacteria. Although the “pioneering strategy” of discovering completely new drugs is a rational approach, the time and effort taken are considerable, the process of drug development could instead be expedited if efforts were concentrated on enhancing the efficacy of existing antimicrobials through: combination therapies; bacteriophage therapy; antimicrobial adjuvants therapy or the application of nanotechnology. This review will briefly detail the causes and mechanisms of AMR as background, and then provide insights into a novel, future emerging or evolving strategies that are currently being evaluated and which may be developed in the future to tackle the progression of AMR. Bentham Science Publishers 2020-03-04 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/86706/1/Mechanisms%20of%20antimicrobial%20resistance%20.pdf Moo, Chew Li and Yang, Shun Kai and Yusoff, Khatijah and Ajat, Mokrish and Warren, Thomas and Abushelaibi, Aisha and Lim, Swee Hua Erin and Lai, Kok Song (2020) Mechanisms of antimicrobial resistance (AMR) and alternative approaches to overcome AMR. Current Drug Discovery Technologies, 17 (4). 430 - 447. ISSN 1570-1638; ESSN:1875-6220 https://www.eurekaselect.com/170403/article 10.2174/1570163816666190304122219 |
| spellingShingle | Moo, Chew Li Yang, Shun Kai Yusoff, Khatijah Ajat, Mokrish Warren, Thomas Abushelaibi, Aisha Lim, Swee Hua Erin Lai, Kok Song Mechanisms of antimicrobial resistance (AMR) and alternative approaches to overcome AMR |
| title | Mechanisms of antimicrobial resistance (AMR) and alternative approaches to overcome AMR |
| title_full | Mechanisms of antimicrobial resistance (AMR) and alternative approaches to overcome AMR |
| title_fullStr | Mechanisms of antimicrobial resistance (AMR) and alternative approaches to overcome AMR |
| title_full_unstemmed | Mechanisms of antimicrobial resistance (AMR) and alternative approaches to overcome AMR |
| title_short | Mechanisms of antimicrobial resistance (AMR) and alternative approaches to overcome AMR |
| title_sort | mechanisms of antimicrobial resistance (amr) and alternative approaches to overcome amr |
| url | http://psasir.upm.edu.my/id/eprint/86706/ http://psasir.upm.edu.my/id/eprint/86706/ http://psasir.upm.edu.my/id/eprint/86706/ http://psasir.upm.edu.my/id/eprint/86706/1/Mechanisms%20of%20antimicrobial%20resistance%20.pdf |