Hypocholesterolaemic and anti-atherogenic effects of palm-based oils (NoveLin I and NoveLin II) in cholesterol-fed rabbits
NoveLin I and NoveLin II are palm-based oils. NoveLin I has an equal distribution of saturated, monounsaturated and polyunsaturated fatty acids, whereas NoveLin II has a moderate level of monounsaturated fatty acids, and a lower content of saturated and polyunsaturated fatty acids. However, their hy...
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| Format: | Article |
| Language: | English |
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MDPI
2020
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| Online Access: | http://psasir.upm.edu.my/id/eprint/78159/ http://psasir.upm.edu.my/id/eprint/78159/1/78159.pdf |
| _version_ | 1848858429932699648 |
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| author | Che Idris, Che Anishas Siew, Wai Lin Abdull Razis, Ahmad Faizal |
| author_facet | Che Idris, Che Anishas Siew, Wai Lin Abdull Razis, Ahmad Faizal |
| author_sort | Che Idris, Che Anishas |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | NoveLin I and NoveLin II are palm-based oils. NoveLin I has an equal distribution of saturated, monounsaturated and polyunsaturated fatty acids, whereas NoveLin II has a moderate level of monounsaturated fatty acids, and a lower content of saturated and polyunsaturated fatty acids. However, their hypocholesterolaemic and anti-atherogenic effects have not been studied. Therefore, this study aimed to assess the hypocholesterolaemic and anti-atherogenic effects of these oils. Forty male New Zealand White rabbits were divided into four groups and fed with diets containing 35% energy fat with added 0.15% (w/w) dietary cholesterol. Group 1, as the control group (CNO) was fed with a diet containing coconut oil, group 2 and 3 were fed with diets containing either NoveLin I or NoveLin II, and group 4, was fed with diet containing olive oil (OLV) for 100 days. Our results demonstrated that both NoveLin groups have significantly lower total cholesterol and low-density lipoprotein–cholesterol (LDL–C) compared to CNO group and are comparable to the OLV group. Low density lipoprotein–cholesterol/high density lipoprotein-cholesterol (LDL/HDL–C) ratio was significantly lower after the NoveLin II diet but attained significance only in comparison to NoveLin I and CNO groups. Aortic fibrous plaque score was significantly lower in both NoveLin groups compared to CNO group. Our findings suggest that despite the high-fat cholesterol diet, NoveLin II oil resulted in atherogenic effects comparable to olive oil. |
| first_indexed | 2025-11-15T12:13:19Z |
| format | Article |
| id | upm-78159 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T12:13:19Z |
| publishDate | 2020 |
| publisher | MDPI |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-781592020-06-15T07:26:31Z http://psasir.upm.edu.my/id/eprint/78159/ Hypocholesterolaemic and anti-atherogenic effects of palm-based oils (NoveLin I and NoveLin II) in cholesterol-fed rabbits Che Idris, Che Anishas Siew, Wai Lin Abdull Razis, Ahmad Faizal NoveLin I and NoveLin II are palm-based oils. NoveLin I has an equal distribution of saturated, monounsaturated and polyunsaturated fatty acids, whereas NoveLin II has a moderate level of monounsaturated fatty acids, and a lower content of saturated and polyunsaturated fatty acids. However, their hypocholesterolaemic and anti-atherogenic effects have not been studied. Therefore, this study aimed to assess the hypocholesterolaemic and anti-atherogenic effects of these oils. Forty male New Zealand White rabbits were divided into four groups and fed with diets containing 35% energy fat with added 0.15% (w/w) dietary cholesterol. Group 1, as the control group (CNO) was fed with a diet containing coconut oil, group 2 and 3 were fed with diets containing either NoveLin I or NoveLin II, and group 4, was fed with diet containing olive oil (OLV) for 100 days. Our results demonstrated that both NoveLin groups have significantly lower total cholesterol and low-density lipoprotein–cholesterol (LDL–C) compared to CNO group and are comparable to the OLV group. Low density lipoprotein–cholesterol/high density lipoprotein-cholesterol (LDL/HDL–C) ratio was significantly lower after the NoveLin II diet but attained significance only in comparison to NoveLin I and CNO groups. Aortic fibrous plaque score was significantly lower in both NoveLin groups compared to CNO group. Our findings suggest that despite the high-fat cholesterol diet, NoveLin II oil resulted in atherogenic effects comparable to olive oil. MDPI 2020 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/78159/1/78159.pdf Che Idris, Che Anishas and Siew, Wai Lin and Abdull Razis, Ahmad Faizal (2020) Hypocholesterolaemic and anti-atherogenic effects of palm-based oils (NoveLin I and NoveLin II) in cholesterol-fed rabbits. International Journal of Environmental Research and Public Health, 17 (9). art. no. 3226. pp. 1-10. ISSN 1661-7827; ESSN: 1660-4601 https://www.mdpi.com/1660-4601/17/9/3226 10.3390/ijerph17093226 |
| spellingShingle | Che Idris, Che Anishas Siew, Wai Lin Abdull Razis, Ahmad Faizal Hypocholesterolaemic and anti-atherogenic effects of palm-based oils (NoveLin I and NoveLin II) in cholesterol-fed rabbits |
| title | Hypocholesterolaemic and anti-atherogenic effects of palm-based oils (NoveLin I and NoveLin II) in cholesterol-fed rabbits |
| title_full | Hypocholesterolaemic and anti-atherogenic effects of palm-based oils (NoveLin I and NoveLin II) in cholesterol-fed rabbits |
| title_fullStr | Hypocholesterolaemic and anti-atherogenic effects of palm-based oils (NoveLin I and NoveLin II) in cholesterol-fed rabbits |
| title_full_unstemmed | Hypocholesterolaemic and anti-atherogenic effects of palm-based oils (NoveLin I and NoveLin II) in cholesterol-fed rabbits |
| title_short | Hypocholesterolaemic and anti-atherogenic effects of palm-based oils (NoveLin I and NoveLin II) in cholesterol-fed rabbits |
| title_sort | hypocholesterolaemic and anti-atherogenic effects of palm-based oils (novelin i and novelin ii) in cholesterol-fed rabbits |
| url | http://psasir.upm.edu.my/id/eprint/78159/ http://psasir.upm.edu.my/id/eprint/78159/ http://psasir.upm.edu.my/id/eprint/78159/ http://psasir.upm.edu.my/id/eprint/78159/1/78159.pdf |