BDMC33, a curcumin derivative suppresses inflammatory responses in macrophage-like cellular system: role of inhibition in NF-κB and MAPK signaling pathways
Our preliminary screening has shown that curcumin derivative BDMC33 [2,6-bis(2,5-dimethoxybenzylidene)cyclohexanone] exerted promising nitric oxide inhibitory activity in activated macrophages. However, the molecular basis and mechanism for its pharmacological action is yet to be elucidated. The aim...
| Main Authors: | Lee, Ka Heng, Chow, Yuh Lit, Vidyadaran, Sharmili, Abas, Faridah, Mohammed Alitheen, Noorjahan Banu, Shaari, Khozirah, Israf Ali, Daud Ahmad, Lajis, Nordin, Ahmad, Syahida |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI
2012
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/78007/ http://psasir.upm.edu.my/id/eprint/78007/1/78007.pdf |
Similar Items
A curcumin derivative, 2,6-bis(2,5-dimethoxybenzylidene)-cyclohexanone (BDMC33) attenuates prostaglandin E2 synthesis via selective suppression of cyclooxygenase-2 in IFN-γ/LPS-stimulated macrophages..
by: Lee, Ka Heng, et al.
Published: (2011)
by: Lee, Ka Heng, et al.
Published: (2011)
Cardamonin inhibits COX and iNOS expression via inhibition of p65NF-κB nuclear translocation and Iκ-B phosphorylation in RAW 264.7 macrophage cells
by: Israf Ali, Daud Ahmad, et al.
Published: (2007)
by: Israf Ali, Daud Ahmad, et al.
Published: (2007)
Atrovirinone inhibits proinflammatory mediator synthesis through disruption of NF-kappaB nuclear translocation and MAPK phosphorylation in the murine monocytic macrophage RAW 264.7.
by: Israf Ali, Daud Ahmad, et al.
Published: (2010)
by: Israf Ali, Daud Ahmad, et al.
Published: (2010)
Effects of curcumin analogue, 2, 6-bis (2, 5-dimethoxybenzylidene) cyclohexanone (BDMC33) on the activities of drug-metabolizing enzymes in cultured Caco-2 cell model
by: Yakubu, Ndatsu, et al.
Published: (2016)
by: Yakubu, Ndatsu, et al.
Published: (2016)
Curcumin derivative, 2,6-bis(2-fluorobenzylidene)cyclohexanone (MS65) inhibits interleukin-6 production through suppression of NF-κB and MAPK pathways in histamine-induced human keratinocytes cell (HaCaT)
by: Razali, Nurul Atika, et al.
Published: (2018)
by: Razali, Nurul Atika, et al.
Published: (2018)
Human renal carcinoma cells respond to Newcastle disease virus infection through activation of the p38 MAPK/NF-κB/IκBα pathway
by: Ch'ng, Wei Choong, et al.
Published: (2015)
by: Ch'ng, Wei Choong, et al.
Published: (2015)
In silico study and effects of BDMC33 on TNBS-Induced BMP gene expressions in zebrafish gut inflammation-Associated arthritis
by: Mostofa, Farhana, et al.
Published: (2022)
by: Mostofa, Farhana, et al.
Published: (2022)
Cardamonin from Alpinia rafflesiana Wall. ex Baker as inhibitor of inflammatory responses in IFN-Gamma/LPS-Stimulated microglial cell line (BV2) via NF-κB signalling pathway
by: Chow, Yuh Lit
Published: (2012)
by: Chow, Yuh Lit
Published: (2012)
Role of NF-κB in tumorigenesis
by: Shanmugam, M., et al.
Published: (2013)
by: Shanmugam, M., et al.
Published: (2013)
NF-κB in cancer therapy
by: Li, F., et al.
Published: (2015)
by: Li, F., et al.
Published: (2015)
Polyphenols mitigating inflammatory mechanisms in Inflammatory Bowel Disease (IBD): focus on NF-κB and JAK/STAT pathways
by: Ismail, Elysha Nur, et al.
Published: (2024)
by: Ismail, Elysha Nur, et al.
Published: (2024)
Chemopreventive effects of a curcumin‐like diarylpentanoid [2,6‐bis(2,5‐dimethoxybenzylidene)cyclohexanone] in cellular targets of rheumatoid arthritis in vitro
by: Lee, Ka Heng, et al.
Published: (2015)
by: Lee, Ka Heng, et al.
Published: (2015)
Phyllanthus amarus prevents LPS-mediated BV2 microglial activation via MyD88 and NF-κB signaling pathways
by: Ismail, Elysha Nur, et al.
Published: (2020)
by: Ismail, Elysha Nur, et al.
Published: (2020)
Suppression of PGE2 production via disruption of MAPK
phosphorylation by unsymmetrical dicarbonyl curcumin
derivatives
by: Mohd Aluwi, Mohd Fadhlizil Fasihi, et al.
Published: (2017)
by: Mohd Aluwi, Mohd Fadhlizil Fasihi, et al.
Published: (2017)
Suppression of PGE2 production via disruption of MAPK phosphorylation by unsymmetrical dicarbonyl curcumin derivatives
by: Aluwi, Mohd Fadhlizil Fasihi Mohd, et al.
Published: (2017)
by: Aluwi, Mohd Fadhlizil Fasihi Mohd, et al.
Published: (2017)
Suppression of proinflammatory cytokines and mediators in LPS-induced RAW 264.7 macrophages by stem extract of Alternanthera sessilis via the inhibition of the NF-κB pathway
by: Muniandy, Katyakyini, et al.
Published: (2018)
by: Muniandy, Katyakyini, et al.
Published: (2018)
Synthesis and biological evaluation of curcumin-like diarylpentanoid analogues for anti-inflammatory, antioxidant and anti-tyrosinase activities
by: Ka-Heng, Lee, et al.
Published: (2009)
by: Ka-Heng, Lee, et al.
Published: (2009)
Therapeutic potential of mushrooms: a review on NF-κB modulation in chronic inflammation
by: Amirullah, Nur Amalina, et al.
Published: (2024)
by: Amirullah, Nur Amalina, et al.
Published: (2024)
Severity of asthma: the role of CD25+,CD30+, NF-κB, and apoptotic markers
by: Abdulamir, Ahmed Sahib, et al.
Published: (2009)
by: Abdulamir, Ahmed Sahib, et al.
Published: (2009)
α7-Nicotinic Acetylcholine Receptor activation modulates BV2 microglial plasticity via miR-21/TNF-α/NFκB in oxygen–glucose deprivation/reoxygenation
by: Hasan, Mohammad Yusuf, et al.
Published: (2024)
by: Hasan, Mohammad Yusuf, et al.
Published: (2024)
Immunomodulatory action of new curcumin analogue [2,6-BIS(2,5-dimethoxybenzylidene) cyclohexanone] on major inflammatory mediator expression in activated macrophage and synovial fibroblast cells
by: Lee, Ka Heng
Published: (2012)
by: Lee, Ka Heng
Published: (2012)
Effect of compounds isolated from natural products on IFN-γ/LPS- induced nitric oxide production in RAW 264.7 macrophages
by: Ahmad, Syahida, et al.
Published: (2006)
by: Ahmad, Syahida, et al.
Published: (2006)
Inhibition of epithelial CC-family chemokine synthesis by the synthetic chalcone DMPF-1 via disruption of NF-κB nuclear translocation and suppression of experimental asthma in mice
by: Rajajendram, Revathee, et al.
Published: (2015)
by: Rajajendram, Revathee, et al.
Published: (2015)
Screening for novel endogenous inflammatory stimuli using the secreted embryonic alkaline phosphatase NF-κB reporter assay
by: Zuliani-Alvarez, Lorena, et al.
Published: (2017)
by: Zuliani-Alvarez, Lorena, et al.
Published: (2017)
Deciphering the role of NF-κB and STAT-1/3 in the pathology of a murine model of Lewy Body Dementia
by: Cooper, Jack John
Published: (2019)
by: Cooper, Jack John
Published: (2019)
Receptor activator of NF-κB ligand promotes proliferation of a putative mammary stem cell unique to the lactating epithelium
by: Thomas, E., et al.
Published: (2012)
by: Thomas, E., et al.
Published: (2012)
The effects of lauric acid on Pi3k and Nfκb signaling pathways in alcohol-induced hepg2 cells
by: Lua, Ying Huan
Published: (2018)
by: Lua, Ying Huan
Published: (2018)
The synthetic curcuminoid BHMC restores endotoxin-stimulated HUVEC dysfunction: specific disruption on enzymatic activity of p38 MAPK
by: Chau, Ling Tham, et al.
Published: (2015)
by: Chau, Ling Tham, et al.
Published: (2015)
Essential oil and leaves from Lantana camara significantly ameliorate different cancer cell lines by suppressing the NF-κB pathway
by: Sajid, Arfaa, et al.
Published: (2021)
by: Sajid, Arfaa, et al.
Published: (2021)
Mechanism of NF-κB signaling in BMP-2-induced dental stem cell odontogeneic differentiation on human amniotic membrane scaffold
by: Chandra, Hamshawagini
Published: (2018)
by: Chandra, Hamshawagini
Published: (2018)
Use of the curcumin analog BHMC in the treatment of endothelial dysfunction and related disorders
by: Israf Ali, Daud Ahmad, et al.
Published: (2012)
by: Israf Ali, Daud Ahmad, et al.
Published: (2012)
Loss of epithelial Gq and G11 signaling inhibits TGFbeta production but promotes IL-33-mediated macrophage polarization and emphysema
by: John, A.E., et al.
Published: (2016)
by: John, A.E., et al.
Published: (2016)
Naringin attenuates the development of carrageenan-induced acute lung inflammation through inhibition of NF-κb, STAT3 and pro-inflammatory mediators and enhancement of IκBα and anti-inflammatory cytokines
by: Ahmad, Sheikh Fayaz, et al.
Published: (2015)
by: Ahmad, Sheikh Fayaz, et al.
Published: (2015)
Curcumin modulates nuclear factor kB (NF-KB)-mediated
inflammation in human tenocytes in vitro:
Role of the PHOSPHATIDYLINOSITOL 3-KINASE/Akt PATHWAY
by: Buhrmann, Constanze, et al.
Published: (2011)
by: Buhrmann, Constanze, et al.
Published: (2011)
Loss of epithelial Gq and G11 signaling inhibits TGFβ production but promotes IL-33–mediated macrophage polarization and emphysema
by: John, Alison, E., et al.
Published: (2016)
by: John, Alison, E., et al.
Published: (2016)
Celastrol inhibits proliferation and induces chemosensitization through down-regulation of NF-κB and STAT3 regulated gene products in multiple myeloma cells
by: Kannaiyan, R., et al.
Published: (2011)
by: Kannaiyan, R., et al.
Published: (2011)
Flavonoids as natural anti-inflammatory agents targeting nuclear factor-kappa B (NFκB) signalling in cardiovascular diseases: a mini review
by: Choy, Ker Woon, et al.
Published: (2019)
by: Choy, Ker Woon, et al.
Published: (2019)
Caffeic acid phenethyl ester attenuates dextran sulfate sodium-induced ulcerative colitis through modulation of NF-κB and cell adhesion molecules
by: Pandurangan, Ashok Kumar, et al.
Published: (2022)
by: Pandurangan, Ashok Kumar, et al.
Published: (2022)
An assessment of alveolar macrophage activity in dogs
by: Hamzah, Hazilawati, et al.
Published: (1999)
by: Hamzah, Hazilawati, et al.
Published: (1999)
Thymoquinone overcomes chemoresistance and enhances the anticancer effects of bortezomib through abrogation of NF-κB regulated gene products in multiple myeloma xenograft mouse model
by: Siveen, K., et al.
Published: (2014)
by: Siveen, K., et al.
Published: (2014)
Similar Items
-
A curcumin derivative, 2,6-bis(2,5-dimethoxybenzylidene)-cyclohexanone (BDMC33) attenuates prostaglandin E2 synthesis via selective suppression of cyclooxygenase-2 in IFN-γ/LPS-stimulated macrophages..
by: Lee, Ka Heng, et al.
Published: (2011) -
Cardamonin inhibits COX and iNOS expression via inhibition of p65NF-κB nuclear translocation and Iκ-B phosphorylation in RAW 264.7 macrophage cells
by: Israf Ali, Daud Ahmad, et al.
Published: (2007) -
Atrovirinone inhibits proinflammatory mediator synthesis through disruption of NF-kappaB nuclear translocation and MAPK phosphorylation in the murine monocytic macrophage RAW 264.7.
by: Israf Ali, Daud Ahmad, et al.
Published: (2010) -
Effects of curcumin analogue, 2, 6-bis (2, 5-dimethoxybenzylidene) cyclohexanone (BDMC33) on the activities of drug-metabolizing enzymes in cultured Caco-2 cell model
by: Yakubu, Ndatsu, et al.
Published: (2016) -
Curcumin derivative, 2,6-bis(2-fluorobenzylidene)cyclohexanone (MS65) inhibits interleukin-6 production through suppression of NF-κB and MAPK pathways in histamine-induced human keratinocytes cell (HaCaT)
by: Razali, Nurul Atika, et al.
Published: (2018)