A new cytotoxic carbazole alkaloid from Clausena excavata

A new carbazole alkaloid, 3-carbomethoxy-2-hydroxy-7-methoxycarbazole, Clausine-TY (1),together with two known carbazole alkaloid, Clausine-H (2) and Clausine-B (3), were isolated from the ethyl acetate extract of the stem bark of the Malaysian Clausena excavata. The structures of these compounds we...

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Bibliographic Details
Main Authors: Yap, Taufiq Yun Hin, Peh, Tian Hai, Ee, Gwendoline Cheng Lian, Rahmani, Mawardi, Md. Sukari, Mohd Aspollah, Ali, Abdul Manaf, Muse, Radzali
Format: Article
Language:English
Published: Taylor & Francis 2007
Online Access:http://psasir.upm.edu.my/id/eprint/7660/
http://psasir.upm.edu.my/id/eprint/7660/1/A%20new%20Cytotoxic%20Carbazole%20Alkaloid%20from%20Clausena%20excavata.pdf
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Summary:A new carbazole alkaloid, 3-carbomethoxy-2-hydroxy-7-methoxycarbazole, Clausine-TY (1),together with two known carbazole alkaloid, Clausine-H (2) and Clausine-B (3), were isolated from the ethyl acetate extract of the stem bark of the Malaysian Clausena excavata. The structures of these compounds were elucidated by spectroscopic analyses. The new carbazole alkaloid shows significant cytotoxicity against CEM-SS cell line.