Pre-emptive multimodal analgesia with tramadol and ketamine–lidocaine infusion for suppression of central sensitization in a dog model of ovariohysterectomy
Objectives: The effects of pre-emptive infusion of ketamine-lidocaine with tramadol on the suppression of central sensitization were investigated in a dog ovariohysterectomy model. Patients and methods: Twelve dogs were randomly assigned to two groups: ketamine-lidocaine-tramadol (KLT) and tramadol...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2018
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| Online Access: | http://psasir.upm.edu.my/id/eprint/73596/ http://psasir.upm.edu.my/id/eprint/73596/1/Pre-emptive%20multimodal%20analgesia%20with%20tramadol%20and%20ketamine%E2%80%93lidocaine%20infusion%20for%20suppression%20of%20central%20sensitization%20in%20a%20dog%20model%20of%20ovariohysterectomy.pdf |
| _version_ | 1848857312815480832 |
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| author | Kaka, Ubedullah Rahman, Nor Alimah Abubakar, Adamu Abdul Goh, Yong Meng Fakurazi, Sharida Omar, Mohamed Ariff Chen, Hui Cheng |
| author_facet | Kaka, Ubedullah Rahman, Nor Alimah Abubakar, Adamu Abdul Goh, Yong Meng Fakurazi, Sharida Omar, Mohamed Ariff Chen, Hui Cheng |
| author_sort | Kaka, Ubedullah |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Objectives: The effects of pre-emptive infusion of ketamine-lidocaine with tramadol on the suppression of central sensitization were investigated in a dog ovariohysterectomy model. Patients and methods: Twelve dogs were randomly assigned to two groups: ketamine-lidocaine-tramadol (KLT) and tramadol (T) groups. Both groups received intravenous tramadol 4 mg/kg body weight as premedication. Immediately after induction, the KLT group received ketamine and lidocaine at 0.5 and 2 mg/kg loading dose, followed by continuous rate infusion of 50 and 100 µg/kg/min, respectively, for 2 hours. Dogs in T group received saline bolus and continuous rate infusion at equi-volume. Intraoperatively, hemodynamic responses to surgical stimulation were recorded, whereas postoperative pain was evaluated using an algometer and short form of the Glasgow composite measure pain scale. Results: Intraoperatively, hemodynamic responses to surgical stimulation were obtunded to a greater degree in KLT compared to T group. Postoperatively, the pain scores increased only for the first hour in KLT group, compared to 12 hours in T group. Mechanical thresholds at the abdomen decreased postoperatively between 12 and 60 hours in KLT group versus the entire 72 hours in T group. Thresholds at tibia and radius in both groups increased in the immediate 1 hour postoperatively, but decreased thereafter. Significant decrement of thresholds from baseline were detected in the tibia at 24, 42, and 60 hours in KLT group compared to 24-72 hours in T group, and in the radius between 36 and 48 hours in T group, but none in KLT group. Conclusion: Addition of pre-emptive ketamine-lidocaine infusion to single intravenous dose of tramadol enhanced attenuation of central sensitization and improved intra- and postoperative analgesia. |
| first_indexed | 2025-11-15T11:55:33Z |
| format | Article |
| id | upm-73596 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T11:55:33Z |
| publishDate | 2018 |
| publisher | Dove Medical Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-735962020-06-30T00:49:07Z http://psasir.upm.edu.my/id/eprint/73596/ Pre-emptive multimodal analgesia with tramadol and ketamine–lidocaine infusion for suppression of central sensitization in a dog model of ovariohysterectomy Kaka, Ubedullah Rahman, Nor Alimah Abubakar, Adamu Abdul Goh, Yong Meng Fakurazi, Sharida Omar, Mohamed Ariff Chen, Hui Cheng Objectives: The effects of pre-emptive infusion of ketamine-lidocaine with tramadol on the suppression of central sensitization were investigated in a dog ovariohysterectomy model. Patients and methods: Twelve dogs were randomly assigned to two groups: ketamine-lidocaine-tramadol (KLT) and tramadol (T) groups. Both groups received intravenous tramadol 4 mg/kg body weight as premedication. Immediately after induction, the KLT group received ketamine and lidocaine at 0.5 and 2 mg/kg loading dose, followed by continuous rate infusion of 50 and 100 µg/kg/min, respectively, for 2 hours. Dogs in T group received saline bolus and continuous rate infusion at equi-volume. Intraoperatively, hemodynamic responses to surgical stimulation were recorded, whereas postoperative pain was evaluated using an algometer and short form of the Glasgow composite measure pain scale. Results: Intraoperatively, hemodynamic responses to surgical stimulation were obtunded to a greater degree in KLT compared to T group. Postoperatively, the pain scores increased only for the first hour in KLT group, compared to 12 hours in T group. Mechanical thresholds at the abdomen decreased postoperatively between 12 and 60 hours in KLT group versus the entire 72 hours in T group. Thresholds at tibia and radius in both groups increased in the immediate 1 hour postoperatively, but decreased thereafter. Significant decrement of thresholds from baseline were detected in the tibia at 24, 42, and 60 hours in KLT group compared to 24-72 hours in T group, and in the radius between 36 and 48 hours in T group, but none in KLT group. Conclusion: Addition of pre-emptive ketamine-lidocaine infusion to single intravenous dose of tramadol enhanced attenuation of central sensitization and improved intra- and postoperative analgesia. Dove Medical Press 2018 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/73596/1/Pre-emptive%20multimodal%20analgesia%20with%20tramadol%20and%20ketamine%E2%80%93lidocaine%20infusion%20for%20suppression%20of%20central%20sensitization%20in%20a%20dog%20model%20of%20ovariohysterectomy.pdf Kaka, Ubedullah and Rahman, Nor Alimah and Abubakar, Adamu Abdul and Goh, Yong Meng and Fakurazi, Sharida and Omar, Mohamed Ariff and Chen, Hui Cheng (2018) Pre-emptive multimodal analgesia with tramadol and ketamine–lidocaine infusion for suppression of central sensitization in a dog model of ovariohysterectomy. Journal of Pain Research, 11. 743 - 752. ISSN ESSN: 1178-7090 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905489/pdf/jpr-11-743.pdf 10.2147/JPR.S152475 |
| spellingShingle | Kaka, Ubedullah Rahman, Nor Alimah Abubakar, Adamu Abdul Goh, Yong Meng Fakurazi, Sharida Omar, Mohamed Ariff Chen, Hui Cheng Pre-emptive multimodal analgesia with tramadol and ketamine–lidocaine infusion for suppression of central sensitization in a dog model of ovariohysterectomy |
| title | Pre-emptive multimodal analgesia with tramadol and ketamine–lidocaine infusion for suppression of central sensitization in a dog model of ovariohysterectomy |
| title_full | Pre-emptive multimodal analgesia with tramadol and ketamine–lidocaine infusion for suppression of central sensitization in a dog model of ovariohysterectomy |
| title_fullStr | Pre-emptive multimodal analgesia with tramadol and ketamine–lidocaine infusion for suppression of central sensitization in a dog model of ovariohysterectomy |
| title_full_unstemmed | Pre-emptive multimodal analgesia with tramadol and ketamine–lidocaine infusion for suppression of central sensitization in a dog model of ovariohysterectomy |
| title_short | Pre-emptive multimodal analgesia with tramadol and ketamine–lidocaine infusion for suppression of central sensitization in a dog model of ovariohysterectomy |
| title_sort | pre-emptive multimodal analgesia with tramadol and ketamine–lidocaine infusion for suppression of central sensitization in a dog model of ovariohysterectomy |
| url | http://psasir.upm.edu.my/id/eprint/73596/ http://psasir.upm.edu.my/id/eprint/73596/ http://psasir.upm.edu.my/id/eprint/73596/ http://psasir.upm.edu.my/id/eprint/73596/1/Pre-emptive%20multimodal%20analgesia%20with%20tramadol%20and%20ketamine%E2%80%93lidocaine%20infusion%20for%20suppression%20of%20central%20sensitization%20in%20a%20dog%20model%20of%20ovariohysterectomy.pdf |