Predisposition to insulin resistance and obesity due to staple consumption of rice: amylose content versus germination status
Type 2 diabetes is a metabolic disorder with established, well-defined precursors. Obesity and insulin resistance are amongst most important factors in predisposition to diabetes. Rice is a staple for about half the global population and its consumption has been strongly linked with diabetogenesis....
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| Language: | English |
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Public Library of Science
2017
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| Online Access: | http://psasir.upm.edu.my/id/eprint/62814/ http://psasir.upm.edu.my/id/eprint/62814/1/Predisposition%20to%20insulin%20.pdf |
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| author | Abubakar, Bilyaminu Zawawi, Norhasnida Omar, Abdul Rahman Ismail, Maznah |
| author_facet | Abubakar, Bilyaminu Zawawi, Norhasnida Omar, Abdul Rahman Ismail, Maznah |
| author_sort | Abubakar, Bilyaminu |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Type 2 diabetes is a metabolic disorder with established, well-defined precursors. Obesity and insulin resistance are amongst most important factors in predisposition to diabetes. Rice is a staple for about half the global population and its consumption has been strongly linked with diabetogenesis. We assert that tackling the prevalence of predisposing factors by modifying certain rice cultivars could reduce the global burden of obesity and insulin resistance, and by extension type 2 diabetes. Several rice cultivars with various properties were fed to nulliparous rats (five weeks old at the start of the experiment) for 90 days. They were then returned to a diet of standard pellets and mated with males raised on a standard diet. The resulting pups and dams were investigated for obesity and insulin resistance markers. We found that germination did more to reduce predisposition to obesity and insulin resistance than high amylose content. The combined reducing effect of germination and high amylose content on predisposition to obesity and insulin resistance was greater than the sum of their independent effects. Polished (white) rice with a low amylose content predisposed dams on a high-fat diet to markers of insulin resistance and obesity and this predisposition was inherited (in biochemical terms) by their F1 offspring. Overall, the results suggest that harnessing the beneficial properties of germination and amylose in rice would reduce the burden of obesity and insulin resistance, which are known to be key risk factors for development of type 2 diabetes. |
| first_indexed | 2025-11-15T11:13:34Z |
| format | Article |
| id | upm-62814 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T11:13:34Z |
| publishDate | 2017 |
| publisher | Public Library of Science |
| recordtype | eprints |
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| spelling | upm-628142022-11-09T04:17:47Z http://psasir.upm.edu.my/id/eprint/62814/ Predisposition to insulin resistance and obesity due to staple consumption of rice: amylose content versus germination status Abubakar, Bilyaminu Zawawi, Norhasnida Omar, Abdul Rahman Ismail, Maznah Type 2 diabetes is a metabolic disorder with established, well-defined precursors. Obesity and insulin resistance are amongst most important factors in predisposition to diabetes. Rice is a staple for about half the global population and its consumption has been strongly linked with diabetogenesis. We assert that tackling the prevalence of predisposing factors by modifying certain rice cultivars could reduce the global burden of obesity and insulin resistance, and by extension type 2 diabetes. Several rice cultivars with various properties were fed to nulliparous rats (five weeks old at the start of the experiment) for 90 days. They were then returned to a diet of standard pellets and mated with males raised on a standard diet. The resulting pups and dams were investigated for obesity and insulin resistance markers. We found that germination did more to reduce predisposition to obesity and insulin resistance than high amylose content. The combined reducing effect of germination and high amylose content on predisposition to obesity and insulin resistance was greater than the sum of their independent effects. Polished (white) rice with a low amylose content predisposed dams on a high-fat diet to markers of insulin resistance and obesity and this predisposition was inherited (in biochemical terms) by their F1 offspring. Overall, the results suggest that harnessing the beneficial properties of germination and amylose in rice would reduce the burden of obesity and insulin resistance, which are known to be key risk factors for development of type 2 diabetes. Public Library of Science 2017-07 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/62814/1/Predisposition%20to%20insulin%20.pdf Abubakar, Bilyaminu and Zawawi, Norhasnida and Omar, Abdul Rahman and Ismail, Maznah (2017) Predisposition to insulin resistance and obesity due to staple consumption of rice: amylose content versus germination status. PLoS One, 12 (7). pp. 1-15. ISSN 1932-6203 https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0181309&type=printable 10.1371/journal.pone.0181309 |
| spellingShingle | Abubakar, Bilyaminu Zawawi, Norhasnida Omar, Abdul Rahman Ismail, Maznah Predisposition to insulin resistance and obesity due to staple consumption of rice: amylose content versus germination status |
| title | Predisposition to insulin resistance and obesity due to staple consumption of rice: amylose content versus germination status |
| title_full | Predisposition to insulin resistance and obesity due to staple consumption of rice: amylose content versus germination status |
| title_fullStr | Predisposition to insulin resistance and obesity due to staple consumption of rice: amylose content versus germination status |
| title_full_unstemmed | Predisposition to insulin resistance and obesity due to staple consumption of rice: amylose content versus germination status |
| title_short | Predisposition to insulin resistance and obesity due to staple consumption of rice: amylose content versus germination status |
| title_sort | predisposition to insulin resistance and obesity due to staple consumption of rice: amylose content versus germination status |
| url | http://psasir.upm.edu.my/id/eprint/62814/ http://psasir.upm.edu.my/id/eprint/62814/ http://psasir.upm.edu.my/id/eprint/62814/ http://psasir.upm.edu.my/id/eprint/62814/1/Predisposition%20to%20insulin%20.pdf |