Joint modelling of longitudinal 3MS scores and the risk of mortality among cognitively impaired individuals
Background: Modified Mini-Mental State Examination (3MS) is an instrument administered by trained personnel to examine levels of participants’ cognitive function. However, the association between changes in scores over time and the risk of death (mortality) is not known. The aims of this study are...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science
2017
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| Online Access: | http://psasir.upm.edu.my/id/eprint/62244/ http://psasir.upm.edu.my/id/eprint/62244/1/Joint%20modelling%20of%20longitudinal%203MS%20scores.pdf |
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| author | Guure, Chris Bambey Ibrahim, Noor Akma Adam, Mohd Bakri Md Said, Salmiah |
| author_facet | Guure, Chris Bambey Ibrahim, Noor Akma Adam, Mohd Bakri Md Said, Salmiah |
| author_sort | Guure, Chris Bambey |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Background: Modified Mini-Mental State Examination (3MS) is an instrument administered by trained personnel to examine levels of participants’ cognitive function. However, the association between changes in scores over time and the risk of death (mortality) is not known. The
aims of this study are to examine the association between 3MS scores and mortality via cognitive impairment among older women and to determine individuals’ risk of changes in scores to better predict their survival and mortality rates. Methods: We propose a Bayesian joint modelling approach to determine mortality due to cognitive
impairment via repeated measures of 3MS scores trajectories over a 21-year follow-up period. Data for this study are taken from the Osteoporotic Fracture longitudinal study among women aged 65+ which started in 1986–88. Results: The standard relative risk model from the analyses with a baseline 3MS score after adjusting
for all the significant covariates demonstrates that, every unit decrease in a 3MS score corresponds to a non-significant 1.059 increase risk of mortality with a 95% CI of (0.981, 1.143), while the extended model results in a significant 0.09% increased risk in mortality. The joint modelling approach found a strong association between the 3MS scores and the risk of mortality, such that, every unit decrease in 3MS scores results in a 1.135 (13%)
increased risk of death via cognitive impairment with a 95% CI of (1.056, 1.215). Conclusion: It has been demonstrated that a decrease in 3MS results has a significant increase risk of mortality due to cognitive impairment via joint modelling, but insignificant when considered under the standard relative risk approach. |
| first_indexed | 2025-11-15T11:12:19Z |
| format | Article |
| id | upm-62244 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T11:12:19Z |
| publishDate | 2017 |
| publisher | Public Library of Science |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-622442019-05-23T01:27:34Z http://psasir.upm.edu.my/id/eprint/62244/ Joint modelling of longitudinal 3MS scores and the risk of mortality among cognitively impaired individuals Guure, Chris Bambey Ibrahim, Noor Akma Adam, Mohd Bakri Md Said, Salmiah Background: Modified Mini-Mental State Examination (3MS) is an instrument administered by trained personnel to examine levels of participants’ cognitive function. However, the association between changes in scores over time and the risk of death (mortality) is not known. The aims of this study are to examine the association between 3MS scores and mortality via cognitive impairment among older women and to determine individuals’ risk of changes in scores to better predict their survival and mortality rates. Methods: We propose a Bayesian joint modelling approach to determine mortality due to cognitive impairment via repeated measures of 3MS scores trajectories over a 21-year follow-up period. Data for this study are taken from the Osteoporotic Fracture longitudinal study among women aged 65+ which started in 1986–88. Results: The standard relative risk model from the analyses with a baseline 3MS score after adjusting for all the significant covariates demonstrates that, every unit decrease in a 3MS score corresponds to a non-significant 1.059 increase risk of mortality with a 95% CI of (0.981, 1.143), while the extended model results in a significant 0.09% increased risk in mortality. The joint modelling approach found a strong association between the 3MS scores and the risk of mortality, such that, every unit decrease in 3MS scores results in a 1.135 (13%) increased risk of death via cognitive impairment with a 95% CI of (1.056, 1.215). Conclusion: It has been demonstrated that a decrease in 3MS results has a significant increase risk of mortality due to cognitive impairment via joint modelling, but insignificant when considered under the standard relative risk approach. Public Library of Science 2017 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/62244/1/Joint%20modelling%20of%20longitudinal%203MS%20scores.pdf Guure, Chris Bambey and Ibrahim, Noor Akma and Adam, Mohd Bakri and Md Said, Salmiah (2017) Joint modelling of longitudinal 3MS scores and the risk of mortality among cognitively impaired individuals. PLOS ONE, 12 (8). pp. 1-18. ISSN 1932-6203 https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0182873 10.1371/journal.pone.0182873 |
| spellingShingle | Guure, Chris Bambey Ibrahim, Noor Akma Adam, Mohd Bakri Md Said, Salmiah Joint modelling of longitudinal 3MS scores and the risk of mortality among cognitively impaired individuals |
| title | Joint modelling of longitudinal 3MS scores and the risk of mortality among cognitively impaired individuals |
| title_full | Joint modelling of longitudinal 3MS scores and the risk of mortality among cognitively impaired individuals |
| title_fullStr | Joint modelling of longitudinal 3MS scores and the risk of mortality among cognitively impaired individuals |
| title_full_unstemmed | Joint modelling of longitudinal 3MS scores and the risk of mortality among cognitively impaired individuals |
| title_short | Joint modelling of longitudinal 3MS scores and the risk of mortality among cognitively impaired individuals |
| title_sort | joint modelling of longitudinal 3ms scores and the risk of mortality among cognitively impaired individuals |
| url | http://psasir.upm.edu.my/id/eprint/62244/ http://psasir.upm.edu.my/id/eprint/62244/ http://psasir.upm.edu.my/id/eprint/62244/ http://psasir.upm.edu.my/id/eprint/62244/1/Joint%20modelling%20of%20longitudinal%203MS%20scores.pdf |