Flower-like copper sulfide nanocrystals are highly effective against chloroquine-resistant plasmodium falciparum and the malaria vector Anopheles stephensi
Anopheles stephensi is a mosquito of outstanding public health relevance, acting as a major vector of malaria in a number of tropical and subtropical areas worldwide. In recent years, important efforts have been conducted to propose nano-formulated larvicides as valuable alternatives to synthetic in...
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Springer Link
2017
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| Online Access: | http://psasir.upm.edu.my/id/eprint/61900/ http://psasir.upm.edu.my/id/eprint/61900/1/Flower-like%20copper%20sulfide%20nanocrystals%20.pdf |
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| author | Theerthagiri, Jayaraman Madhavan, Jagan Murugan, Kadarkarai Samidoss, Christina Mary Kumar, Suresh Higuchi, Akon Benelli, Giovanni |
| author_facet | Theerthagiri, Jayaraman Madhavan, Jagan Murugan, Kadarkarai Samidoss, Christina Mary Kumar, Suresh Higuchi, Akon Benelli, Giovanni |
| author_sort | Theerthagiri, Jayaraman |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Anopheles stephensi is a mosquito of outstanding public health relevance, acting as a major vector of malaria in a number of tropical and subtropical areas worldwide. In recent years, important efforts have been conducted to propose nano-formulated larvicides as valuable alternatives to synthetic insecticides currently marketed. In the present study, the toxicity of flower-like copper sulfide (CuS) nanocrystals has been investigated on the malaria vector A. stephensi and Plasmodium parasites. Characterization of synthesized CuS nanocrystals was carried out using FTIR spectroscopy, XRD analysis, FESEM, HR-TEM and EDS. In mosquitocidal assays, LC50 values ranged from 23.347 ppm (first-instar larvae) to 48.789 ppm (pupae). In vitro anti-plasmodial activity of CuS nanoflowers was evaluated against chloroquine-resistant (CQ-r) and CQ-sensitive (CQ-s) strains of Plasmodium falciparum. IC50were 83.44 μg/mL (CQ-s) and 87.15 μg/mL (CQ-r). However, in vivo antiplasmodial experiments conducted on Plasmodium berghei infecting albino mice showed limited activity of CuS nanocrystals, if compared to CQ. Overall, our findings showed that chemically synthesized flower-like CuS nanocrystals are promising to improve the effectiveness of mosquito control programs, as well as to develop novel antiplasmodial drugs. |
| first_indexed | 2025-11-15T11:11:04Z |
| format | Article |
| id | upm-61900 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T11:11:04Z |
| publishDate | 2017 |
| publisher | Springer Link |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-619002019-02-26T08:52:34Z http://psasir.upm.edu.my/id/eprint/61900/ Flower-like copper sulfide nanocrystals are highly effective against chloroquine-resistant plasmodium falciparum and the malaria vector Anopheles stephensi Theerthagiri, Jayaraman Madhavan, Jagan Murugan, Kadarkarai Samidoss, Christina Mary Kumar, Suresh Higuchi, Akon Benelli, Giovanni Anopheles stephensi is a mosquito of outstanding public health relevance, acting as a major vector of malaria in a number of tropical and subtropical areas worldwide. In recent years, important efforts have been conducted to propose nano-formulated larvicides as valuable alternatives to synthetic insecticides currently marketed. In the present study, the toxicity of flower-like copper sulfide (CuS) nanocrystals has been investigated on the malaria vector A. stephensi and Plasmodium parasites. Characterization of synthesized CuS nanocrystals was carried out using FTIR spectroscopy, XRD analysis, FESEM, HR-TEM and EDS. In mosquitocidal assays, LC50 values ranged from 23.347 ppm (first-instar larvae) to 48.789 ppm (pupae). In vitro anti-plasmodial activity of CuS nanoflowers was evaluated against chloroquine-resistant (CQ-r) and CQ-sensitive (CQ-s) strains of Plasmodium falciparum. IC50were 83.44 μg/mL (CQ-s) and 87.15 μg/mL (CQ-r). However, in vivo antiplasmodial experiments conducted on Plasmodium berghei infecting albino mice showed limited activity of CuS nanocrystals, if compared to CQ. Overall, our findings showed that chemically synthesized flower-like CuS nanocrystals are promising to improve the effectiveness of mosquito control programs, as well as to develop novel antiplasmodial drugs. Springer Link 2017-01 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/61900/1/Flower-like%20copper%20sulfide%20nanocrystals%20.pdf Theerthagiri, Jayaraman and Madhavan, Jagan and Murugan, Kadarkarai and Samidoss, Christina Mary and Kumar, Suresh and Higuchi, Akon and Benelli, Giovanni (2017) Flower-like copper sulfide nanocrystals are highly effective against chloroquine-resistant plasmodium falciparum and the malaria vector Anopheles stephensi. Journal of Cluster Science, 28 (1). 581 - 594. ISSN 1040-7278; ESSN: 1572-8862 https://link.springer.com/article/10.1007/s10876-016-1128-2 10.1007/s10876-016-1128-2 |
| spellingShingle | Theerthagiri, Jayaraman Madhavan, Jagan Murugan, Kadarkarai Samidoss, Christina Mary Kumar, Suresh Higuchi, Akon Benelli, Giovanni Flower-like copper sulfide nanocrystals are highly effective against chloroquine-resistant plasmodium falciparum and the malaria vector Anopheles stephensi |
| title | Flower-like copper sulfide nanocrystals are highly effective against chloroquine-resistant plasmodium falciparum and the malaria vector Anopheles stephensi |
| title_full | Flower-like copper sulfide nanocrystals are highly effective against chloroquine-resistant plasmodium falciparum and the malaria vector Anopheles stephensi |
| title_fullStr | Flower-like copper sulfide nanocrystals are highly effective against chloroquine-resistant plasmodium falciparum and the malaria vector Anopheles stephensi |
| title_full_unstemmed | Flower-like copper sulfide nanocrystals are highly effective against chloroquine-resistant plasmodium falciparum and the malaria vector Anopheles stephensi |
| title_short | Flower-like copper sulfide nanocrystals are highly effective against chloroquine-resistant plasmodium falciparum and the malaria vector Anopheles stephensi |
| title_sort | flower-like copper sulfide nanocrystals are highly effective against chloroquine-resistant plasmodium falciparum and the malaria vector anopheles stephensi |
| url | http://psasir.upm.edu.my/id/eprint/61900/ http://psasir.upm.edu.my/id/eprint/61900/ http://psasir.upm.edu.my/id/eprint/61900/ http://psasir.upm.edu.my/id/eprint/61900/1/Flower-like%20copper%20sulfide%20nanocrystals%20.pdf |