Effects of environmental stresses and in vitro digestion on the release of tocotrienols encapsulated within chitosan-alginate microcapsules
Considering the health benefits of tocotrienols, continuous works have been done on the encapsulation and delivery of these compounds. In this study, we encapsulated tocotrienols in chitosan-alginate microcapsules and evaluated their release profile. Generally, these tocotrienols microcapsules (TM)...
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| Format: | Article |
| Language: | English |
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American Chemical Society
2017
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| Online Access: | http://psasir.upm.edu.my/id/eprint/61648/ http://psasir.upm.edu.my/id/eprint/61648/1/Effects%20of%20environmental%20stresses%20and%20in%20vitro%20digestion%20.pdf |
| _version_ | 1848854457387843584 |
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| author | Tan, Phui Yee Tan, Tai Boon Chang, Hon Weng Tey, Beng Ti Chan, Eng Seng Lai, Oi Ming Baharin, Badlishah Sham Nehdi, Imededdine Arbi Tan, Chin Ping |
| author_facet | Tan, Phui Yee Tan, Tai Boon Chang, Hon Weng Tey, Beng Ti Chan, Eng Seng Lai, Oi Ming Baharin, Badlishah Sham Nehdi, Imededdine Arbi Tan, Chin Ping |
| author_sort | Tan, Phui Yee |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Considering the health benefits of tocotrienols, continuous works have been done on the encapsulation and delivery of these compounds. In this study, we encapsulated tocotrienols in chitosan-alginate microcapsules and evaluated their release profile. Generally, these tocotrienols microcapsules (TM) displayed high thermal stability. When subjected to pH adjustments (pH 1–9), we observed that the release of tocotrienols was the highest (33.78 ± 0.18%) under basic conditions. The TM were also unstable against the effect of ionic strength, with a high release (70.73 ± 0.04%) of tocotrienols even at a low sodium chloride concentration (50 mM). As for the individual isomers, δ-tocotrienol was the most sensitive to pH and ionic strength. In contrast, β-/γ-tocotrienols were the most ionic-stable isomers but more responsive toward thermal treatment. Simulated gastrointestinal model showed that the chitosan-alginate-based TM could be used to retain tocotrienols in the gastric and subsequently release them in the intestines for possible absorption. |
| first_indexed | 2025-11-15T11:10:10Z |
| format | Article |
| id | upm-61648 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T11:10:10Z |
| publishDate | 2017 |
| publisher | American Chemical Society |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-616482018-10-24T08:11:40Z http://psasir.upm.edu.my/id/eprint/61648/ Effects of environmental stresses and in vitro digestion on the release of tocotrienols encapsulated within chitosan-alginate microcapsules Tan, Phui Yee Tan, Tai Boon Chang, Hon Weng Tey, Beng Ti Chan, Eng Seng Lai, Oi Ming Baharin, Badlishah Sham Nehdi, Imededdine Arbi Tan, Chin Ping Considering the health benefits of tocotrienols, continuous works have been done on the encapsulation and delivery of these compounds. In this study, we encapsulated tocotrienols in chitosan-alginate microcapsules and evaluated their release profile. Generally, these tocotrienols microcapsules (TM) displayed high thermal stability. When subjected to pH adjustments (pH 1–9), we observed that the release of tocotrienols was the highest (33.78 ± 0.18%) under basic conditions. The TM were also unstable against the effect of ionic strength, with a high release (70.73 ± 0.04%) of tocotrienols even at a low sodium chloride concentration (50 mM). As for the individual isomers, δ-tocotrienol was the most sensitive to pH and ionic strength. In contrast, β-/γ-tocotrienols were the most ionic-stable isomers but more responsive toward thermal treatment. Simulated gastrointestinal model showed that the chitosan-alginate-based TM could be used to retain tocotrienols in the gastric and subsequently release them in the intestines for possible absorption. American Chemical Society 2017 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/61648/1/Effects%20of%20environmental%20stresses%20and%20in%20vitro%20digestion%20.pdf Tan, Phui Yee and Tan, Tai Boon and Chang, Hon Weng and Tey, Beng Ti and Chan, Eng Seng and Lai, Oi Ming and Baharin, Badlishah Sham and Nehdi, Imededdine Arbi and Tan, Chin Ping (2017) Effects of environmental stresses and in vitro digestion on the release of tocotrienols encapsulated within chitosan-alginate microcapsules. Journal of Agricultural and Food Chemistry, 65 (48). 10651 - 10657. ISSN 0021-8561 https://pubs.acs.org/doi/abs/10.1021/acs.jafc.7b03521 10.1021/acs.jafc.7b03521 |
| spellingShingle | Tan, Phui Yee Tan, Tai Boon Chang, Hon Weng Tey, Beng Ti Chan, Eng Seng Lai, Oi Ming Baharin, Badlishah Sham Nehdi, Imededdine Arbi Tan, Chin Ping Effects of environmental stresses and in vitro digestion on the release of tocotrienols encapsulated within chitosan-alginate microcapsules |
| title | Effects of environmental stresses and in vitro digestion on the release of tocotrienols encapsulated within chitosan-alginate microcapsules |
| title_full | Effects of environmental stresses and in vitro digestion on the release of tocotrienols encapsulated within chitosan-alginate microcapsules |
| title_fullStr | Effects of environmental stresses and in vitro digestion on the release of tocotrienols encapsulated within chitosan-alginate microcapsules |
| title_full_unstemmed | Effects of environmental stresses and in vitro digestion on the release of tocotrienols encapsulated within chitosan-alginate microcapsules |
| title_short | Effects of environmental stresses and in vitro digestion on the release of tocotrienols encapsulated within chitosan-alginate microcapsules |
| title_sort | effects of environmental stresses and in vitro digestion on the release of tocotrienols encapsulated within chitosan-alginate microcapsules |
| url | http://psasir.upm.edu.my/id/eprint/61648/ http://psasir.upm.edu.my/id/eprint/61648/ http://psasir.upm.edu.my/id/eprint/61648/ http://psasir.upm.edu.my/id/eprint/61648/1/Effects%20of%20environmental%20stresses%20and%20in%20vitro%20digestion%20.pdf |