Anti-obesity and anti-inflammatory effects of synthetic acetic acid vinegar and Nipa vinegar on high-fat-diet-induced obese mice
Recently, food-based bioactive ingredients, such as vinegar, have been proposed as a potential solution to overcome the global obesity epidemic. Although acetic acid has been identified as the main component in vinegar that contributes to its anti-obesity effect, reports have shown that vinegar prod...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2017
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| Online Access: | http://psasir.upm.edu.my/id/eprint/60889/ http://psasir.upm.edu.my/id/eprint/60889/1/Anti-obesity%20and%20anti-inflammatory%20effects%20of%20synthetic%20acetic%20acid%20vinegar%20and%20Nipa%20vinegar%20on%20high-fat-diet-induced%20obese%20mice.pdf |
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| author | Beh, Boon Kee Mohamad, Nurul Elyani Swee, Keong Yeap Huynh, Ky Boo, Sook Yee Yi, Joelle Heng Chua Tan, Sheau Wei Wan, Yong Ho Sharifuddin, Shaiful Adzni Long, Kamariah Mohammed Alitheen, Noorjahan Banu |
| author_facet | Beh, Boon Kee Mohamad, Nurul Elyani Swee, Keong Yeap Huynh, Ky Boo, Sook Yee Yi, Joelle Heng Chua Tan, Sheau Wei Wan, Yong Ho Sharifuddin, Shaiful Adzni Long, Kamariah Mohammed Alitheen, Noorjahan Banu |
| author_sort | Beh, Boon Kee |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Recently, food-based bioactive ingredients, such as vinegar, have been proposed as a potential solution to overcome the global obesity epidemic. Although acetic acid has been identified as the main component in vinegar that contributes to its anti-obesity effect, reports have shown that vinegar produced from different starting materials possess different degrees of bioactivity. This study was performed to compare the anti-obesity and anti-inflammatory effects of synthetic acetic acid vinegar and Nipa vinegar in mice fed a high-fat diet. In this work, mice were fed a high-fat diet for 33 weeks. At the start of week 24, obese mice were orally fed synthetic acetic acid vinegar or Nipa vinegar (0.08 and 2 ml/kg BW) until the end of week 33. Mice fed a standard pellet diet served as a control. Although both synthetic acetic acid vinegar and Nipa vinegar effectively reduced food intake and body weight, a high dose of Nipa vinegar more effectively reduced lipid deposition, improved the serum lipid profile, increased adipokine expression and suppressed inflammation in the obese mice. Thus, a high dose of Nipa vinegar may potentially alleviate obesity by altering the lipid metabolism, inflammation and gut microbe composition in high-fat-diet-induced obese mice. |
| first_indexed | 2025-11-15T11:07:33Z |
| format | Article |
| id | upm-60889 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T11:07:33Z |
| publishDate | 2017 |
| publisher | Nature Publishing Group |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-608892019-04-29T08:14:39Z http://psasir.upm.edu.my/id/eprint/60889/ Anti-obesity and anti-inflammatory effects of synthetic acetic acid vinegar and Nipa vinegar on high-fat-diet-induced obese mice Beh, Boon Kee Mohamad, Nurul Elyani Swee, Keong Yeap Huynh, Ky Boo, Sook Yee Yi, Joelle Heng Chua Tan, Sheau Wei Wan, Yong Ho Sharifuddin, Shaiful Adzni Long, Kamariah Mohammed Alitheen, Noorjahan Banu Recently, food-based bioactive ingredients, such as vinegar, have been proposed as a potential solution to overcome the global obesity epidemic. Although acetic acid has been identified as the main component in vinegar that contributes to its anti-obesity effect, reports have shown that vinegar produced from different starting materials possess different degrees of bioactivity. This study was performed to compare the anti-obesity and anti-inflammatory effects of synthetic acetic acid vinegar and Nipa vinegar in mice fed a high-fat diet. In this work, mice were fed a high-fat diet for 33 weeks. At the start of week 24, obese mice were orally fed synthetic acetic acid vinegar or Nipa vinegar (0.08 and 2 ml/kg BW) until the end of week 33. Mice fed a standard pellet diet served as a control. Although both synthetic acetic acid vinegar and Nipa vinegar effectively reduced food intake and body weight, a high dose of Nipa vinegar more effectively reduced lipid deposition, improved the serum lipid profile, increased adipokine expression and suppressed inflammation in the obese mice. Thus, a high dose of Nipa vinegar may potentially alleviate obesity by altering the lipid metabolism, inflammation and gut microbe composition in high-fat-diet-induced obese mice. Nature Publishing Group 2017 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/60889/1/Anti-obesity%20and%20anti-inflammatory%20effects%20of%20synthetic%20acetic%20acid%20vinegar%20and%20Nipa%20vinegar%20on%20high-fat-diet-induced%20obese%20mice.pdf Beh, Boon Kee and Mohamad, Nurul Elyani and Swee, Keong Yeap and Huynh, Ky and Boo, Sook Yee and Yi, Joelle Heng Chua and Tan, Sheau Wei and Wan, Yong Ho and Sharifuddin, Shaiful Adzni and Long, Kamariah and Mohammed Alitheen, Noorjahan Banu (2017) Anti-obesity and anti-inflammatory effects of synthetic acetic acid vinegar and Nipa vinegar on high-fat-diet-induced obese mice. Scientific Reports, 7 (1). pp. 1-9. ISSN 2045-2322; ESSN: 2045-2322 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5532206/pdf/41598_2017_Article_6235.pdf 10.1038/s41598-017-06235-7 |
| spellingShingle | Beh, Boon Kee Mohamad, Nurul Elyani Swee, Keong Yeap Huynh, Ky Boo, Sook Yee Yi, Joelle Heng Chua Tan, Sheau Wei Wan, Yong Ho Sharifuddin, Shaiful Adzni Long, Kamariah Mohammed Alitheen, Noorjahan Banu Anti-obesity and anti-inflammatory effects of synthetic acetic acid vinegar and Nipa vinegar on high-fat-diet-induced obese mice |
| title | Anti-obesity and anti-inflammatory effects of synthetic acetic acid vinegar and Nipa vinegar on high-fat-diet-induced obese mice |
| title_full | Anti-obesity and anti-inflammatory effects of synthetic acetic acid vinegar and Nipa vinegar on high-fat-diet-induced obese mice |
| title_fullStr | Anti-obesity and anti-inflammatory effects of synthetic acetic acid vinegar and Nipa vinegar on high-fat-diet-induced obese mice |
| title_full_unstemmed | Anti-obesity and anti-inflammatory effects of synthetic acetic acid vinegar and Nipa vinegar on high-fat-diet-induced obese mice |
| title_short | Anti-obesity and anti-inflammatory effects of synthetic acetic acid vinegar and Nipa vinegar on high-fat-diet-induced obese mice |
| title_sort | anti-obesity and anti-inflammatory effects of synthetic acetic acid vinegar and nipa vinegar on high-fat-diet-induced obese mice |
| url | http://psasir.upm.edu.my/id/eprint/60889/ http://psasir.upm.edu.my/id/eprint/60889/ http://psasir.upm.edu.my/id/eprint/60889/ http://psasir.upm.edu.my/id/eprint/60889/1/Anti-obesity%20and%20anti-inflammatory%20effects%20of%20synthetic%20acetic%20acid%20vinegar%20and%20Nipa%20vinegar%20on%20high-fat-diet-induced%20obese%20mice.pdf |