Cytotoxic and antimicrobial xanthones from Cratoxylum arborescens (Guttiferae)
Phytochemical and biological studies were carried out the stem bark of Cratoxylum arborescens collected from Sarawak, Malaysia. Chromatographic separation of the plant extracts led to the isolation of three xanthones, a-mangostin (1), ß-mangostin (2) and fuscaxanthone C (3) together with the commom...
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| Format: | Article |
| Language: | English |
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Faculty of Science, University of Malaya
2013
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| Online Access: | http://psasir.upm.edu.my/id/eprint/56236/ http://psasir.upm.edu.my/id/eprint/56236/1/Cytotoxic%20and%20antimicrobial%20xanthones%20from%20Cratoxylum%20arborescens%20%28Guttiferae%29.pdf |
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| author | Yahayu, Maizatul Akmal Rahmani, Mawardi Mohd Hashim, Najihah Ee, Gwendoline Cheng Lian Md. Sukari, Mohd Aspollah Md. Akim, Abdah |
| author_facet | Yahayu, Maizatul Akmal Rahmani, Mawardi Mohd Hashim, Najihah Ee, Gwendoline Cheng Lian Md. Sukari, Mohd Aspollah Md. Akim, Abdah |
| author_sort | Yahayu, Maizatul Akmal |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Phytochemical and biological studies were carried out the stem bark of Cratoxylum arborescens collected from Sarawak, Malaysia. Chromatographic separation of the plant extracts led to the isolation of three xanthones, a-mangostin (1), ß-mangostin (2) and fuscaxanthone C (3) together with the commom stigmasterol. The structural elucidation of the compound was determined by detail spectroscopic analysis and comparison with literature reports. a-Mangostin exhibited strong inhibition on the growth of bacteria, B. subtilis, B. cereus, S. typhimurium and S. aureus with inhibition zone of 16, 20, 17 and 20 mm, respectively. Both a-mangostin and ß-mangostin showed the most significant cytotoxic activity against MCF7 cells with IC50 values of 12.48 μg/ml and 28.42 μg/ml, respectively. However, when tested for antioxidant activity by using DPPH, the extracts and the xanthones failed to give good results. |
| first_indexed | 2025-11-15T10:47:25Z |
| format | Article |
| id | upm-56236 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T10:47:25Z |
| publishDate | 2013 |
| publisher | Faculty of Science, University of Malaya |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-562362017-07-04T02:48:08Z http://psasir.upm.edu.my/id/eprint/56236/ Cytotoxic and antimicrobial xanthones from Cratoxylum arborescens (Guttiferae) Yahayu, Maizatul Akmal Rahmani, Mawardi Mohd Hashim, Najihah Ee, Gwendoline Cheng Lian Md. Sukari, Mohd Aspollah Md. Akim, Abdah Phytochemical and biological studies were carried out the stem bark of Cratoxylum arborescens collected from Sarawak, Malaysia. Chromatographic separation of the plant extracts led to the isolation of three xanthones, a-mangostin (1), ß-mangostin (2) and fuscaxanthone C (3) together with the commom stigmasterol. The structural elucidation of the compound was determined by detail spectroscopic analysis and comparison with literature reports. a-Mangostin exhibited strong inhibition on the growth of bacteria, B. subtilis, B. cereus, S. typhimurium and S. aureus with inhibition zone of 16, 20, 17 and 20 mm, respectively. Both a-mangostin and ß-mangostin showed the most significant cytotoxic activity against MCF7 cells with IC50 values of 12.48 μg/ml and 28.42 μg/ml, respectively. However, when tested for antioxidant activity by using DPPH, the extracts and the xanthones failed to give good results. Faculty of Science, University of Malaya 2013 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/56236/1/Cytotoxic%20and%20antimicrobial%20xanthones%20from%20Cratoxylum%20arborescens%20%28Guttiferae%29.pdf Yahayu, Maizatul Akmal and Rahmani, Mawardi and Mohd Hashim, Najihah and Ee, Gwendoline Cheng Lian and Md. Sukari, Mohd Aspollah and Md. Akim, Abdah (2013) Cytotoxic and antimicrobial xanthones from Cratoxylum arborescens (Guttiferae). Malaysian Journal of Science, 32 (1). pp. 53-60. ISSN 0126-7906 http://e-journal.um.edu.my/publish/MJS/760-908 |
| spellingShingle | Yahayu, Maizatul Akmal Rahmani, Mawardi Mohd Hashim, Najihah Ee, Gwendoline Cheng Lian Md. Sukari, Mohd Aspollah Md. Akim, Abdah Cytotoxic and antimicrobial xanthones from Cratoxylum arborescens (Guttiferae) |
| title | Cytotoxic and antimicrobial xanthones from Cratoxylum arborescens (Guttiferae) |
| title_full | Cytotoxic and antimicrobial xanthones from Cratoxylum arborescens (Guttiferae) |
| title_fullStr | Cytotoxic and antimicrobial xanthones from Cratoxylum arborescens (Guttiferae) |
| title_full_unstemmed | Cytotoxic and antimicrobial xanthones from Cratoxylum arborescens (Guttiferae) |
| title_short | Cytotoxic and antimicrobial xanthones from Cratoxylum arborescens (Guttiferae) |
| title_sort | cytotoxic and antimicrobial xanthones from cratoxylum arborescens (guttiferae) |
| url | http://psasir.upm.edu.my/id/eprint/56236/ http://psasir.upm.edu.my/id/eprint/56236/ http://psasir.upm.edu.my/id/eprint/56236/1/Cytotoxic%20and%20antimicrobial%20xanthones%20from%20Cratoxylum%20arborescens%20%28Guttiferae%29.pdf |