A semisynthetic diterpenoid lactone inhibits NF-kB signalling to ameliorate inflammation and airway hyperresponsiveness in a mouse asthma model

QR Code

A semisynthetic diterpenoid lactone inhibits NF-kB signalling to ameliorate inflammation and airway hyperresponsiveness in a mouse asthma model

Andrographolide (AGP) and 14-deoxy-11,12-didehydroandrographolide (DDAG), two main diterpenoid constituents of Andrographis paniculata were previously shown to ameliorate asthmatic symptoms in a mouse model. However, due to inadequacies of both compounds in terms of drug-likeness, DDAG analogues wer...

Full description

Bibliographic Details
Main Authors:	Lim, J. C. W., Goh, F. Y., Sagineedu, S. R., Yong, A. C. H., Sidik, S. M., Lajis, N. H., Wong, W. S. F., Stanslas, J.
Format:	Article
Language:	English
Published:	Elsevier 2016
Online Access:	http://psasir.upm.edu.my/id/eprint/54935/ http://psasir.upm.edu.my/id/eprint/54935/1/A%20semisynthetic%20diterpenoid%20lactone%20inhibits%20NF-%CE%BAB%20signalling%20to%20ameliorate%20.pdf

Similar Items

Lignosus rhinocerotis Cooke Ryvarden ameliorates airway inflammation, mucus hypersecretion and airway hyperresponsiveness in a murine model of asthma
by: Johnathan, Malagobadan, et al.
Published: (2021)

Curcumin modulates nuclear factor kB (NF-KB)-mediated inflammation in human tenocytes in vitro: Role of the PHOSPHATIDYLINOSITOL 3-KINASE/Akt PATHWAY
by: Buhrmann, Constanze, et al.
Published: (2011)

Activation of the transcription factor NF-kB by Campylobacter jejuni
by: Alsayeqh, Abdullah Fayez
Published: (2007)

SRS06, a new semisynthetic andrographolide derivative with improved anticancer potency and selectivity, inhibits nuclear factor-kB nuclear binding in the A549 non-small cell lung cancer cell line
by: Lim, Jonathan Chee Woei, et al.
Published: (2015)

Effects of Theaflavins-rich fraction on adhesion molecules and inflammation via NF-KB pathway in stimulated Endothelial cells / Nur Hidayah Mohd Ishak
by: Mohd Ishak, Nur Hidayah
Published: (2015)

Lignosus rhinocerotis extract ameliorates airway inflammation and remodelling via attenuation of TGF-β1 and Activin A in a prolonged induced allergic asthma model
by: Muhamad, Siti-Aminah, et al.
Published: (2023)

Elevated oxidative stress and adaptive response NF-KB HSP 70 in nitrox diving: Experimental study of non divers population
by: Sofia W,
Published: (2011)

Synthesis and Characterization of Semisynthetic Metallothermolysin
by: Khalid, Syarajatul Erma
Published: (2008)

Biosynthesis of bioactive diterpenoids in the medicinal plant Vitex agnus-castus
by: Heskes, Allison M., et al.
Published: (2018)

A synthetic curcuminoid analogue, 2,6-Bis-4-(Hydroxyl-3-Methoxybenzylidine)-Cyclohexanone (BHMC) ameliorates acute airway inflammation of allergic asthma in ovalbumin-sensitized mice
by: Tham, Chau Ling, et al.
Published: (2021)

SRJ23, a new semisynthetic andrographolide derivative: in vitro growth inhibition and mechanisms of cell cycle arrest and apoptosis in prostate cancer cells
by: Wong, Hui Chyn, et al.
Published: (2014)

N-substituted pyrido-1,4-Oxazin-3-ones induce apoptosis of hepatocellular carcinoma cells by targeting NF-kB signaling pathway
by: Mohan, C., et al.
Published: (2018)

SUMO conjugation of STAT1 protects cells from hyperresponsiveness to IFNγ
by: Begitt, Andreas, et al.
Published: (2011)

Protein Structure-Based Design of Novel Semisynthetic Metallotrypsin
by: Misran, Azizah
Published: (2006)

An investigation of potential prognostic indicators and biomarkers (TRAF1, NF- kB and CD14) in renal cancers / Yap Ning Yi
by: Yap, Ning Yi
Published: (2018)

Epithelial IL-6 trans-signaling defines a new asthma phenotype with increased airway inflammation
by: Jevnikar, Zala, et al.
Published: (2018)

Therapeutic potential of mushrooms: a review on NF-κB modulation in chronic inflammation
by: Amirullah, Nur Amalina, et al.
Published: (2024)

Senam Jantung Sehat Seri-I improves physical fitness, decreases the GDS scores and the level of NF-kB plasma elderly depression
by: Nita Fitria,, et al.
Published: (2020)

The effects of tiger milk mushroom (lignosus rhinocerotis) on airway inflammation in murine models of allergic asthma
by: Muhamad, Siti Aminah
Published: (2020)

Synthesis of γ-lactone and δ-lactone analogues of Atranone F via radical cyclisation approach
by: Mohd Fauzi, Nawwar Fathiah
Published: (2013)

Effect of NF-kB inhibitors on its protein expression of stem cells from human extracted deciduous teeth cultured on amniotic membrane scaffold
by: Hamshawagini, Chandra, et al.
Published: (2016)

Severity of asthma: the role of CD25+,CD30+, NF-κB, and apoptotic markers
by: Abdulamir, Ahmed Sahib, et al.
Published: (2009)

In vitro apoptosis induction and inhibition of NF-kB signaling pathway by biseugenol B in PC3 human prostatic cancer cells / Maryam Abbaspour Babaei
by: Maryam, Abbaspour Babaei
Published: (2018)

Biomarkers of airway inflammation: the use of exhaled nitric oxide (FeNO) in the management of adult asthma in UK primary care
by: Wilson, Emma Elizabeth
Published: (2013)

ANXA1 inhibits miRNA-196a in a negative feedback loop through NF-kB and C-Myc to reduce breast cancer proliferation
by: Yuan, Y., et al.
Published: (2016)

Severe asthma exists despite suppressed tissue inflammation: findings of the U-BIOPRED study
by: Wilson, Susan J., et al.
Published: (2016)

Essential oil and leaves from Lantana camara significantly ameliorate different cancer cell lines by suppressing the NF-κB pathway
by: Sajid, Arfaa, et al.
Published: (2021)

A Molecular Modelling Approach for Designing a Novel Semisynthetic Metalloenzyme Based on Thermolysin
by: Jaafar, Ahmad Haniff
Published: (2006)

Immunofluorescence localization of levopimaradiene/abietadiene synthase in methyl jasmonate treated stems of Sitka spruce (Picea sitchensis) shows activation of diterpenoid biosynthesis in cortical and developing traumatic resin ducts
by: Zulak, Katherine, et al.
Published: (2010)

New flavan and alkyl alpha, beta-lactones from the stem bark of Horsfieldia superba.
by: Al-Mekhlafi, Nabil Ali Naji, et al.
Published: (2013)

Evaluation Form for Independent Assessor KB2
by: Universiti Malaysia Sarawak, Centre for Graduate Studies
Published: (2016)

The impact of azithromycin therapy on the airway microbiota in asthma
by: Slater, Mariel, et al.
Published: (2014)

Respirology supplement: Airway inflammation.
by: Eastwood, Peter
Published: (2013)

Standardised Andrographis paniculata Burm. Nees extracts and andrographolide prevent airway inflammation in house dust mite and diisocyanate- induced asthma models
by: Sulaiman, Ibrahim
Published: (2018)

Bronchial brushings for investigating airway inflammation and remodelling
by: Looi, K., et al.
Published: (2011)

Ameliorative activities of Malaysian stingless bee honey on lipopolysaccharide-induced inflammation and oxidative stress In vivo and its underlying mechanisms
by: Ranneh, Yazan
Published: (2018)

Evaluation Form for Independent Assessor Form KB3
by: Universiti Malaysia Sarawak, Centre for Graduate Studies
Published: (2016)

NF-κB in cancer therapy
by: Li, F., et al.
Published: (2015)

Effect of glucono delta lactone and potassium sorbate on the texture and stability of fresh goat milk cheese
by: Zahari, Rasmiza Z., et al.
Published: (2025)

Epithelial Injury and Dysregulated Repair in Small and Large Airways of Lung Transplant Patients is Ameliorated by Azithromycin
by: Kicic, Anthony, et al.
Published: (2014)