A semisynthetic diterpenoid lactone inhibits NF-kB signalling to ameliorate inflammation and airway hyperresponsiveness in a mouse asthma model

A semisynthetic diterpenoid lactone inhibits NF-kB signalling to ameliorate inflammation and airway hyperresponsiveness in a mouse asthma model

Andrographolide (AGP) and 14-deoxy-11,12-didehydroandrographolide (DDAG), two main diterpenoid constituents of Andrographis paniculata were previously shown to ameliorate asthmatic symptoms in a mouse model. However, due to inadequacies of both compounds in terms of drug-likeness, DDAG analogues wer...

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Bibliographic Details
Main Authors: Lim, J. C. W., Goh, F. Y., Sagineedu, S. R., Yong, A. C. H., Sidik, S. M., Lajis, N. H., Wong, W. S. F., Stanslas, J.
Format: Article
Language:English
Published: Elsevier 2016
Online Access:http://psasir.upm.edu.my/id/eprint/54935/
http://psasir.upm.edu.my/id/eprint/54935/1/A%20semisynthetic%20diterpenoid%20lactone%20inhibits%20NF-%CE%BAB%20signalling%20to%20ameliorate%20.pdf

Internet

http://psasir.upm.edu.my/id/eprint/54935/
http://psasir.upm.edu.my/id/eprint/54935/1/A%20semisynthetic%20diterpenoid%20lactone%20inhibits%20NF-%CE%BAB%20signalling%20to%20ameliorate%20.pdf

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