Mechanism of the induction of endoplasmic reticulum stress by the anti-cancer agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT): activation of PERK/eIF2α, IRE1α, ATF6 and calmodulin kinase

Mechanism of the induction of endoplasmic reticulum stress by the anti-cancer agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT): activation of PERK/eIF2α, IRE1α, ATF6 and calmodulin kinase

The endoplasmic reticulum (ER) plays a major role in the synthesis, maturation and folding of proteins and is a critical calcium (Ca2+) reservoir. Cellular stresses lead to an overwhelming accumulation of misfolded proteins in the ER, leading to ER stress and the activation of the unfolded protein r...

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Main Authors: Merlot, Angelica M., Shafie, Nurul Husna, Yu, Yu, Richardson, Vera, Jansson, Patric J., Sahni, Sumit, Lane, Darius J. R., Kovacevic, Zaklina, Kalinowski, Danuta S., Richardson, Des R.
Format: Article
Language:English
Published: Elsevier 2016
Online Access:http://psasir.upm.edu.my/id/eprint/54771/
http://psasir.upm.edu.my/id/eprint/54771/1/Mechanism%20of%20the%20induction%20of%20endoplasmic%20reticulum%20stress%20by%20the%20anti-cancer%20agent.pdf

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