Mechanism of the induction of endoplasmic reticulum stress by the anti-cancer agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT): activation of PERK/eIF2α, IRE1α, ATF6 and calmodulin kinase

Mechanism of the induction of endoplasmic reticulum stress by the anti-cancer agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT): activation of PERK/eIF2α, IRE1α, ATF6 and calmodulin kinase

The endoplasmic reticulum (ER) plays a major role in the synthesis, maturation and folding of proteins and is a critical calcium (Ca2+) reservoir. Cellular stresses lead to an overwhelming accumulation of misfolded proteins in the ER, leading to ER stress and the activation of the unfolded protein r...

Full description

Bibliographic Details
Main Authors: Merlot, Angelica M., Shafie, Nurul Husna, Yu, Yu, Richardson, Vera, Jansson, Patric J., Sahni, Sumit, Lane, Darius J. R., Kovacevic, Zaklina, Kalinowski, Danuta S., Richardson, Des R.
Format: Article
Language:English
Published: Elsevier 2016
Online Access:http://psasir.upm.edu.my/id/eprint/54771/
http://psasir.upm.edu.my/id/eprint/54771/1/Mechanism%20of%20the%20induction%20of%20endoplasmic%20reticulum%20stress%20by%20the%20anti-cancer%20agent.pdf

Internet

http://psasir.upm.edu.my/id/eprint/54771/
http://psasir.upm.edu.my/id/eprint/54771/1/Mechanism%20of%20the%20induction%20of%20endoplasmic%20reticulum%20stress%20by%20the%20anti-cancer%20agent.pdf

Similar Items