In vivo antidiabetic and acute toxicity of spray-dried Vernonia amygdalina water extract
The spray-dried Vernonia amygdalina water extract was evaluated for antidiabetic effect using normoglycaemic, glucose induced hyperglycaemic and streptozotocin induced diabetic mice. This effect was compared with an oral dose of Momordica charantia. Besides, acute toxicity of the extract was also ev...
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| Format: | Article |
| Language: | English |
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Faculty of Food Science and Technology, Universiti Putra Malaysia
2013
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| Online Access: | http://psasir.upm.edu.my/id/eprint/41060/ http://psasir.upm.edu.my/id/eprint/41060/1/In%20vivo%20antidiabetic%20and%20acute%20toxicity%20of%20spray-dried%20Vernonia%20amygdalina%20water%20extract%20%28p613-616%29.pdf |
| _version_ | 1848849594417414144 |
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| author | Yeap, Swee Keong Liang, Woon San Beh, Boon Kee Ho, Wan Yong Noaman, Yousr Abdulhadi Mohammed Alitheen, Noorjahan Banu |
| author_facet | Yeap, Swee Keong Liang, Woon San Beh, Boon Kee Ho, Wan Yong Noaman, Yousr Abdulhadi Mohammed Alitheen, Noorjahan Banu |
| author_sort | Yeap, Swee Keong |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The spray-dried Vernonia amygdalina water extract was evaluated for antidiabetic effect using normoglycaemic, glucose induced hyperglycaemic and streptozotocin induced diabetic mice. This effect was compared with an oral dose of Momordica charantia. Besides, acute toxicity of the extract was also evaluated at concentration 2000 and 5000 mg/kg body weight. The extract was able to reduce blood glucose level in glucose and streptozotocin induced hyperglycaemic mice without causing hypoglycemic effect on fasting normoglycaemic mice. Moreover, mice appeared to be normal and no mortality was observed in the acute toxicity study after treated with up to 5000mg/kg of extract. These results indicated that the spray-dried Vernonia amygdalina water extract was a potential antidiabetic agent which does not induce hypoglycemic and acute toxicity on normal subject. |
| first_indexed | 2025-11-15T09:52:53Z |
| format | Article |
| id | upm-41060 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:52:53Z |
| publishDate | 2013 |
| publisher | Faculty of Food Science and Technology, Universiti Putra Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-410602015-12-10T02:13:57Z http://psasir.upm.edu.my/id/eprint/41060/ In vivo antidiabetic and acute toxicity of spray-dried Vernonia amygdalina water extract Yeap, Swee Keong Liang, Woon San Beh, Boon Kee Ho, Wan Yong Noaman, Yousr Abdulhadi Mohammed Alitheen, Noorjahan Banu The spray-dried Vernonia amygdalina water extract was evaluated for antidiabetic effect using normoglycaemic, glucose induced hyperglycaemic and streptozotocin induced diabetic mice. This effect was compared with an oral dose of Momordica charantia. Besides, acute toxicity of the extract was also evaluated at concentration 2000 and 5000 mg/kg body weight. The extract was able to reduce blood glucose level in glucose and streptozotocin induced hyperglycaemic mice without causing hypoglycemic effect on fasting normoglycaemic mice. Moreover, mice appeared to be normal and no mortality was observed in the acute toxicity study after treated with up to 5000mg/kg of extract. These results indicated that the spray-dried Vernonia amygdalina water extract was a potential antidiabetic agent which does not induce hypoglycemic and acute toxicity on normal subject. Faculty of Food Science and Technology, Universiti Putra Malaysia 2013 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/41060/1/In%20vivo%20antidiabetic%20and%20acute%20toxicity%20of%20spray-dried%20Vernonia%20amygdalina%20water%20extract%20%28p613-616%29.pdf Yeap, Swee Keong and Liang, Woon San and Beh, Boon Kee and Ho, Wan Yong and Noaman, Yousr Abdulhadi and Mohammed Alitheen, Noorjahan Banu (2013) In vivo antidiabetic and acute toxicity of spray-dried Vernonia amygdalina water extract. International Food Research Journal, 20 (2). pp. 613-616. ISSN 1985-4668; ESSN: 2231-7546 http://www.ifrj.upm.edu.my/20%20%2802%29%202013/15%20IFRJ%2020%20%2802%29%202013%20Noorjahan.pdf |
| spellingShingle | Yeap, Swee Keong Liang, Woon San Beh, Boon Kee Ho, Wan Yong Noaman, Yousr Abdulhadi Mohammed Alitheen, Noorjahan Banu In vivo antidiabetic and acute toxicity of spray-dried Vernonia amygdalina water extract |
| title | In vivo antidiabetic and acute toxicity of spray-dried Vernonia amygdalina water extract |
| title_full | In vivo antidiabetic and acute toxicity of spray-dried Vernonia amygdalina water extract |
| title_fullStr | In vivo antidiabetic and acute toxicity of spray-dried Vernonia amygdalina water extract |
| title_full_unstemmed | In vivo antidiabetic and acute toxicity of spray-dried Vernonia amygdalina water extract |
| title_short | In vivo antidiabetic and acute toxicity of spray-dried Vernonia amygdalina water extract |
| title_sort | in vivo antidiabetic and acute toxicity of spray-dried vernonia amygdalina water extract |
| url | http://psasir.upm.edu.my/id/eprint/41060/ http://psasir.upm.edu.my/id/eprint/41060/ http://psasir.upm.edu.my/id/eprint/41060/1/In%20vivo%20antidiabetic%20and%20acute%20toxicity%20of%20spray-dried%20Vernonia%20amygdalina%20water%20extract%20%28p613-616%29.pdf |