Acute phase proteins, interleukin 6, and heat shock protein 70 in broiler chickens administered with corticosterone
An experiment was conducted to determine the effect of corticosterone (CORT) administration on serum ovotransferrin (OVT), α1-acid glycoprotein (AGP), ceruloplasmin (CPN), and IL-6 concentrations, and brain heat shock protein (HSP) 70 expression in broiler chickens. From 14 to 20 d of age, equal num...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Oxford University Press
2014
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| Online Access: | http://psasir.upm.edu.my/id/eprint/36324/ http://psasir.upm.edu.my/id/eprint/36324/1/Acute%20phase%20proteins.pdf |
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| author | Idrus, Zulkifli Najafi, Pardis A. J., Nurfarahin Farjam, Abdoreza Soleimani Kumari, S. Amir, Anna Aryani O’Reilly, E. L. Eckersall, P. D. |
| author_facet | Idrus, Zulkifli Najafi, Pardis A. J., Nurfarahin Farjam, Abdoreza Soleimani Kumari, S. Amir, Anna Aryani O’Reilly, E. L. Eckersall, P. D. |
| author_sort | Idrus, Zulkifli |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | An experiment was conducted to determine the effect of corticosterone (CORT) administration on serum ovotransferrin (OVT), α1-acid glycoprotein (AGP), ceruloplasmin (CPN), and IL-6 concentrations, and brain heat shock protein (HSP) 70 expression in broiler chickens. From 14 to 20 d of age, equal numbers of birds were subjected to either (i) daily intramuscular injection with CORT in ethanol:saline (1:1, vol/vol) at 6 mg/kg of BW, or (ii) daily intramuscular injection with 0.5 mL ethanol:saline (1:1, vol/vol; control). Blood samples were collected before CORT treatment (14 d old), 3 and 7 d after CORT injections, and 4 d after cessation of CORT administration for determination of serum levels of CORT, OVT, AGP, CPN, and IL-6. Brain samples (whole cerebrum) were collected to measure HSP 70 density. Although CORT administration significantly increased feed intake, weight gain was significantly depressed. Administration of CORT also increased CORT, OVT, CPN, AGP, IL-6, and HSP 70 expression. Four days following cessation of CORT administration, OVT declined to the basal level but not CPN and AGP. In conclusion, an elevation in CORT can induce an acute-phase response and HSP 70 expression. Thus, APP and HSP 70 may be of value as indicators of stress in poultry. |
| first_indexed | 2025-11-15T09:32:18Z |
| format | Article |
| id | upm-36324 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:32:18Z |
| publishDate | 2014 |
| publisher | Oxford University Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-363242015-09-17T07:43:01Z http://psasir.upm.edu.my/id/eprint/36324/ Acute phase proteins, interleukin 6, and heat shock protein 70 in broiler chickens administered with corticosterone Idrus, Zulkifli Najafi, Pardis A. J., Nurfarahin Farjam, Abdoreza Soleimani Kumari, S. Amir, Anna Aryani O’Reilly, E. L. Eckersall, P. D. An experiment was conducted to determine the effect of corticosterone (CORT) administration on serum ovotransferrin (OVT), α1-acid glycoprotein (AGP), ceruloplasmin (CPN), and IL-6 concentrations, and brain heat shock protein (HSP) 70 expression in broiler chickens. From 14 to 20 d of age, equal numbers of birds were subjected to either (i) daily intramuscular injection with CORT in ethanol:saline (1:1, vol/vol) at 6 mg/kg of BW, or (ii) daily intramuscular injection with 0.5 mL ethanol:saline (1:1, vol/vol; control). Blood samples were collected before CORT treatment (14 d old), 3 and 7 d after CORT injections, and 4 d after cessation of CORT administration for determination of serum levels of CORT, OVT, AGP, CPN, and IL-6. Brain samples (whole cerebrum) were collected to measure HSP 70 density. Although CORT administration significantly increased feed intake, weight gain was significantly depressed. Administration of CORT also increased CORT, OVT, CPN, AGP, IL-6, and HSP 70 expression. Four days following cessation of CORT administration, OVT declined to the basal level but not CPN and AGP. In conclusion, an elevation in CORT can induce an acute-phase response and HSP 70 expression. Thus, APP and HSP 70 may be of value as indicators of stress in poultry. Oxford University Press 2014 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/36324/1/Acute%20phase%20proteins.pdf Idrus, Zulkifli and Najafi, Pardis and A. J., Nurfarahin and Farjam, Abdoreza Soleimani and Kumari, S. and Amir, Anna Aryani and O’Reilly, E. L. and Eckersall, P. D. (2014) Acute phase proteins, interleukin 6, and heat shock protein 70 in broiler chickens administered with corticosterone. Poultry Science, 93 (12). pp. 3112-3118. ISSN 0032-5791; ESSN: 1525-3171 http://ps.oxfordjournals.org/content/93/12/3112.abstract 10.3382/ps.2014-04099 |
| spellingShingle | Idrus, Zulkifli Najafi, Pardis A. J., Nurfarahin Farjam, Abdoreza Soleimani Kumari, S. Amir, Anna Aryani O’Reilly, E. L. Eckersall, P. D. Acute phase proteins, interleukin 6, and heat shock protein 70 in broiler chickens administered with corticosterone |
| title | Acute phase proteins, interleukin 6, and heat shock protein 70 in broiler chickens administered with corticosterone |
| title_full | Acute phase proteins, interleukin 6, and heat shock protein 70 in broiler chickens administered with corticosterone |
| title_fullStr | Acute phase proteins, interleukin 6, and heat shock protein 70 in broiler chickens administered with corticosterone |
| title_full_unstemmed | Acute phase proteins, interleukin 6, and heat shock protein 70 in broiler chickens administered with corticosterone |
| title_short | Acute phase proteins, interleukin 6, and heat shock protein 70 in broiler chickens administered with corticosterone |
| title_sort | acute phase proteins, interleukin 6, and heat shock protein 70 in broiler chickens administered with corticosterone |
| url | http://psasir.upm.edu.my/id/eprint/36324/ http://psasir.upm.edu.my/id/eprint/36324/ http://psasir.upm.edu.my/id/eprint/36324/ http://psasir.upm.edu.my/id/eprint/36324/1/Acute%20phase%20proteins.pdf |