Metabolic syndrome, abnormal glucose tolerance and high sensitivity-C-reactive protein among women with a history of Gestational Diabetes Mellitus
Background: Gestational Diabetes Mellitus (GDM) is a risk factor for diabetes and cardiovascular diseases. Early detection of cardio-metabolic risks is recommended for management. This study evaluated the associations between Metabolic Syndrome (MetS), abnormal glucose tolerance and cardiovascular r...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Omics Publishing Group
2014
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| Online Access: | http://psasir.upm.edu.my/id/eprint/34495/ http://psasir.upm.edu.my/id/eprint/34495/1/Metabolic%20syndrome.pdf |
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| author | Shyam, Sangeetha Arshad, Fatimah Abdul Ghani, Rohana Abdul Wahab, Norasyikin Chinna, Karuthan Safii, Nik Shanita Mohd Yusof, Barakatun Nisak Kamaruddin, Nor Azmi |
| author_facet | Shyam, Sangeetha Arshad, Fatimah Abdul Ghani, Rohana Abdul Wahab, Norasyikin Chinna, Karuthan Safii, Nik Shanita Mohd Yusof, Barakatun Nisak Kamaruddin, Nor Azmi |
| author_sort | Shyam, Sangeetha |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Background: Gestational Diabetes Mellitus (GDM) is a risk factor for diabetes and cardiovascular diseases. Early detection of cardio-metabolic risks is recommended for management. This study evaluated the associations between Metabolic Syndrome (MetS), abnormal glucose tolerance and cardiovascular risk factors in Malaysian women with prior GDM.
Method: Seventy-seven, non-diabetic women post-GDM, aged 20-40 years (mean BMI: 26.4 ± 4.6kg/m2) with high type 2 diabetes risks, were evaluated at a median of four months postpartum. Their anthropometric and biochemical measurements were obtained.
Results: The overall prevalence of MetS and dysglycaemia were 22% and 29% respectively. Dysglycaemic was predominantly impaired glucose tolerance (IGT: 77%).MetS was higher among dysglycaemic subjects although also detected in 13% of normo glycaemic subjects. Eighty percent of IGT subjects did not have MetS. Sixty-eight percent of subjects had intermediate or high CVD risks (hsCRP>1mg/L). hscRP increased with obesity and was not associated with glycaemic status. Infant birth weight, maternal age and triglycerides were independent predictors of dysglycaemia (p<0.05).
Conclusion: Despite the low prevalence of MetS, elevated levels of hsCRP among these women with prior- GDM was highly prevalent. Normoglycaemic subjects with MetS demonstrated intermediate to high risk hsCRP levels. The findings also emphasize the importance of performing OGTT mainly in older post-GDM women, with higher triglycerides and infants who are large for gestational age. |
| first_indexed | 2025-11-15T09:24:11Z |
| format | Article |
| id | upm-34495 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:24:11Z |
| publishDate | 2014 |
| publisher | Omics Publishing Group |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-344952016-01-27T02:13:24Z http://psasir.upm.edu.my/id/eprint/34495/ Metabolic syndrome, abnormal glucose tolerance and high sensitivity-C-reactive protein among women with a history of Gestational Diabetes Mellitus Shyam, Sangeetha Arshad, Fatimah Abdul Ghani, Rohana Abdul Wahab, Norasyikin Chinna, Karuthan Safii, Nik Shanita Mohd Yusof, Barakatun Nisak Kamaruddin, Nor Azmi Background: Gestational Diabetes Mellitus (GDM) is a risk factor for diabetes and cardiovascular diseases. Early detection of cardio-metabolic risks is recommended for management. This study evaluated the associations between Metabolic Syndrome (MetS), abnormal glucose tolerance and cardiovascular risk factors in Malaysian women with prior GDM. Method: Seventy-seven, non-diabetic women post-GDM, aged 20-40 years (mean BMI: 26.4 ± 4.6kg/m2) with high type 2 diabetes risks, were evaluated at a median of four months postpartum. Their anthropometric and biochemical measurements were obtained. Results: The overall prevalence of MetS and dysglycaemia were 22% and 29% respectively. Dysglycaemic was predominantly impaired glucose tolerance (IGT: 77%).MetS was higher among dysglycaemic subjects although also detected in 13% of normo glycaemic subjects. Eighty percent of IGT subjects did not have MetS. Sixty-eight percent of subjects had intermediate or high CVD risks (hsCRP>1mg/L). hscRP increased with obesity and was not associated with glycaemic status. Infant birth weight, maternal age and triglycerides were independent predictors of dysglycaemia (p<0.05). Conclusion: Despite the low prevalence of MetS, elevated levels of hsCRP among these women with prior- GDM was highly prevalent. Normoglycaemic subjects with MetS demonstrated intermediate to high risk hsCRP levels. The findings also emphasize the importance of performing OGTT mainly in older post-GDM women, with higher triglycerides and infants who are large for gestational age. Omics Publishing Group 2014 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/34495/1/Metabolic%20syndrome.pdf Shyam, Sangeetha and Arshad, Fatimah and Abdul Ghani, Rohana and Abdul Wahab, Norasyikin and Chinna, Karuthan and Safii, Nik Shanita and Mohd Yusof, Barakatun Nisak and Kamaruddin, Nor Azmi (2014) Metabolic syndrome, abnormal glucose tolerance and high sensitivity-C-reactive protein among women with a history of Gestational Diabetes Mellitus. Diabetes & Metabolism, 5 (9). art. no. 424. pp. 1-6. ISSN 2155-6156 http://www.omicsonline.org/open-access/metabolic-syndrome-abnormal-glucose-tolerance-and-high-sensitivity-creactive-protein-among-women-with-a-history-of-gestational-diabetes-mellitus-2155-6156.1000424.php?aid=30679 10.4172/2155-6156.1000424 |
| spellingShingle | Shyam, Sangeetha Arshad, Fatimah Abdul Ghani, Rohana Abdul Wahab, Norasyikin Chinna, Karuthan Safii, Nik Shanita Mohd Yusof, Barakatun Nisak Kamaruddin, Nor Azmi Metabolic syndrome, abnormal glucose tolerance and high sensitivity-C-reactive protein among women with a history of Gestational Diabetes Mellitus |
| title | Metabolic syndrome, abnormal glucose tolerance and high sensitivity-C-reactive protein among women with a history of Gestational Diabetes Mellitus |
| title_full | Metabolic syndrome, abnormal glucose tolerance and high sensitivity-C-reactive protein among women with a history of Gestational Diabetes Mellitus |
| title_fullStr | Metabolic syndrome, abnormal glucose tolerance and high sensitivity-C-reactive protein among women with a history of Gestational Diabetes Mellitus |
| title_full_unstemmed | Metabolic syndrome, abnormal glucose tolerance and high sensitivity-C-reactive protein among women with a history of Gestational Diabetes Mellitus |
| title_short | Metabolic syndrome, abnormal glucose tolerance and high sensitivity-C-reactive protein among women with a history of Gestational Diabetes Mellitus |
| title_sort | metabolic syndrome, abnormal glucose tolerance and high sensitivity-c-reactive protein among women with a history of gestational diabetes mellitus |
| url | http://psasir.upm.edu.my/id/eprint/34495/ http://psasir.upm.edu.my/id/eprint/34495/ http://psasir.upm.edu.my/id/eprint/34495/ http://psasir.upm.edu.my/id/eprint/34495/1/Metabolic%20syndrome.pdf |