Receptor for advanced glycation end products and its involvement in inflammatory diseases
The receptor for advanced glycation end products (RAGE) is a transmembrane receptor of the immunoglobulin superfamily, capable of binding a broad repertoire of ligands. RAGE-ligands interaction induces a series of signal transduction cascades and lead to the activation of transcription factor NF- B...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Hindawi Publishing Corporation
2013
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/29691/ http://psasir.upm.edu.my/id/eprint/29691/1/Receptor%20for%20advanced%20glycation%20end%20products%20and%20its%20involvement%20in%20inflammatory%20diseases.pdf |
| _version_ | 1848846469257232384 |
|---|---|
| author | Chuah, Yaw Kuang Basir, Rusliza Talib, Herni Tie, Tung Hing Nordin, Norshariza |
| author_facet | Chuah, Yaw Kuang Basir, Rusliza Talib, Herni Tie, Tung Hing Nordin, Norshariza |
| author_sort | Chuah, Yaw Kuang |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The receptor for advanced glycation end products (RAGE) is a transmembrane receptor of the immunoglobulin superfamily, capable of binding a broad repertoire of ligands. RAGE-ligands interaction induces a series of signal transduction cascades and lead to the activation of transcription factor NF- B as well as increased expression of cytokines, chemokines, and adhesion molecules. These effects endow RAGE with the role in the signal transduction from pathogen substrates to cell activation during the onset and perpetuation of inflammation. RAGE signaling and downstream pathways have been implicated in a wide spectrum of inflammatory-related pathologic conditions such as arteriosclerosis, Alzheimer's disease, arthritis, acute respiratory failure, and sepsis. Despite the significant progress in other RAGE studies, the functional importance of the receptor in clinical situations and inflammatory diseases still remains to be fully realized. In this review, we will summarize current understandings and lines of evidence on the molecular mechanisms through which RAGE signaling contributes to the pathogenesis of the aforementioned inflammation-associated conditions. |
| first_indexed | 2025-11-15T09:03:12Z |
| format | Article |
| id | upm-29691 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:03:12Z |
| publishDate | 2013 |
| publisher | Hindawi Publishing Corporation |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-296912015-09-15T01:33:20Z http://psasir.upm.edu.my/id/eprint/29691/ Receptor for advanced glycation end products and its involvement in inflammatory diseases Chuah, Yaw Kuang Basir, Rusliza Talib, Herni Tie, Tung Hing Nordin, Norshariza The receptor for advanced glycation end products (RAGE) is a transmembrane receptor of the immunoglobulin superfamily, capable of binding a broad repertoire of ligands. RAGE-ligands interaction induces a series of signal transduction cascades and lead to the activation of transcription factor NF- B as well as increased expression of cytokines, chemokines, and adhesion molecules. These effects endow RAGE with the role in the signal transduction from pathogen substrates to cell activation during the onset and perpetuation of inflammation. RAGE signaling and downstream pathways have been implicated in a wide spectrum of inflammatory-related pathologic conditions such as arteriosclerosis, Alzheimer's disease, arthritis, acute respiratory failure, and sepsis. Despite the significant progress in other RAGE studies, the functional importance of the receptor in clinical situations and inflammatory diseases still remains to be fully realized. In this review, we will summarize current understandings and lines of evidence on the molecular mechanisms through which RAGE signaling contributes to the pathogenesis of the aforementioned inflammation-associated conditions. Hindawi Publishing Corporation 2013 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/29691/1/Receptor%20for%20advanced%20glycation%20end%20products%20and%20its%20involvement%20in%20inflammatory%20diseases.pdf Chuah, Yaw Kuang and Basir, Rusliza and Talib, Herni and Tie, Tung Hing and Nordin, Norshariza (2013) Receptor for advanced glycation end products and its involvement in inflammatory diseases. International Journal of Inflammation, 2013. art. no. 403460. pp. 1-15. ISSN 2090-8040; ESSN: 2042-0099 http://www.hindawi.com/journals/iji/2013/403460/ 10.1155/2013/403460 |
| spellingShingle | Chuah, Yaw Kuang Basir, Rusliza Talib, Herni Tie, Tung Hing Nordin, Norshariza Receptor for advanced glycation end products and its involvement in inflammatory diseases |
| title | Receptor for advanced glycation end products and its involvement in inflammatory diseases |
| title_full | Receptor for advanced glycation end products and its involvement in inflammatory diseases |
| title_fullStr | Receptor for advanced glycation end products and its involvement in inflammatory diseases |
| title_full_unstemmed | Receptor for advanced glycation end products and its involvement in inflammatory diseases |
| title_short | Receptor for advanced glycation end products and its involvement in inflammatory diseases |
| title_sort | receptor for advanced glycation end products and its involvement in inflammatory diseases |
| url | http://psasir.upm.edu.my/id/eprint/29691/ http://psasir.upm.edu.my/id/eprint/29691/ http://psasir.upm.edu.my/id/eprint/29691/ http://psasir.upm.edu.my/id/eprint/29691/1/Receptor%20for%20advanced%20glycation%20end%20products%20and%20its%20involvement%20in%20inflammatory%20diseases.pdf |