Preparation and characterization of Poly (D,L-lactide-co-glycolide) (PLGA) nanoparticles loaded with linamarin for controlled drug release
Poly (D,L-lactide-co-glycolide) nanoparticles loaded with linamarin as a model drug were successfully prepared using the double emulsion solvent evaporation technique. The physicochemical characterization of the formulated nanoparticles revealed that they were spherical, nonaggregated, and negativel...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis
2013
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| Online Access: | http://psasir.upm.edu.my/id/eprint/28677/ http://psasir.upm.edu.my/id/eprint/28677/1/Preparation%20and%20characterization%20of%20Poly.pdf |
| _version_ | 1848846183197310976 |
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| author | Hussein, Ahmed S. Ahmadun, Fakhru'l-Razi Abdullah, Norhafizah |
| author_facet | Hussein, Ahmed S. Ahmadun, Fakhru'l-Razi Abdullah, Norhafizah |
| author_sort | Hussein, Ahmed S. |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Poly (D,L-lactide-co-glycolide) nanoparticles loaded with linamarin as a model drug were successfully prepared using the double emulsion solvent evaporation technique. The physicochemical characterization of the formulated nanoparticles revealed that they were spherical, nonaggregated, and negatively charged, with good drug encapsulation efficiencies (>50%) and average particle sizes <200 nm. Interestingly, all the nanoparticles exhibited dibasic release profiles with a starting burst release within the first 8 h, followed by a controlled release phase lasting four days. Thus, linamarin-loaded nanoparticles indicate a promising candidate for controlled drug release applications. |
| first_indexed | 2025-11-15T08:58:39Z |
| format | Article |
| id | upm-28677 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T08:58:39Z |
| publishDate | 2013 |
| publisher | Taylor & Francis |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-286772015-09-11T02:44:19Z http://psasir.upm.edu.my/id/eprint/28677/ Preparation and characterization of Poly (D,L-lactide-co-glycolide) (PLGA) nanoparticles loaded with linamarin for controlled drug release Hussein, Ahmed S. Ahmadun, Fakhru'l-Razi Abdullah, Norhafizah Poly (D,L-lactide-co-glycolide) nanoparticles loaded with linamarin as a model drug were successfully prepared using the double emulsion solvent evaporation technique. The physicochemical characterization of the formulated nanoparticles revealed that they were spherical, nonaggregated, and negatively charged, with good drug encapsulation efficiencies (>50%) and average particle sizes <200 nm. Interestingly, all the nanoparticles exhibited dibasic release profiles with a starting burst release within the first 8 h, followed by a controlled release phase lasting four days. Thus, linamarin-loaded nanoparticles indicate a promising candidate for controlled drug release applications. Taylor & Francis 2013 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/28677/1/Preparation%20and%20characterization%20of%20Poly.pdf Hussein, Ahmed S. and Ahmadun, Fakhru'l-Razi and Abdullah, Norhafizah (2013) Preparation and characterization of Poly (D,L-lactide-co-glycolide) (PLGA) nanoparticles loaded with linamarin for controlled drug release. International Journal of Polymer Analysis and Characterization, 18 (6). pp. 414-422. ISSN 1023-666X; ESSN: 1563-5341 10.1080/1023666X.2013.786864 |
| spellingShingle | Hussein, Ahmed S. Ahmadun, Fakhru'l-Razi Abdullah, Norhafizah Preparation and characterization of Poly (D,L-lactide-co-glycolide) (PLGA) nanoparticles loaded with linamarin for controlled drug release |
| title | Preparation and characterization of Poly (D,L-lactide-co-glycolide) (PLGA) nanoparticles loaded with linamarin for controlled drug release |
| title_full | Preparation and characterization of Poly (D,L-lactide-co-glycolide) (PLGA) nanoparticles loaded with linamarin for controlled drug release |
| title_fullStr | Preparation and characterization of Poly (D,L-lactide-co-glycolide) (PLGA) nanoparticles loaded with linamarin for controlled drug release |
| title_full_unstemmed | Preparation and characterization of Poly (D,L-lactide-co-glycolide) (PLGA) nanoparticles loaded with linamarin for controlled drug release |
| title_short | Preparation and characterization of Poly (D,L-lactide-co-glycolide) (PLGA) nanoparticles loaded with linamarin for controlled drug release |
| title_sort | preparation and characterization of poly (d,l-lactide-co-glycolide) (plga) nanoparticles loaded with linamarin for controlled drug release |
| url | http://psasir.upm.edu.my/id/eprint/28677/ http://psasir.upm.edu.my/id/eprint/28677/ http://psasir.upm.edu.my/id/eprint/28677/1/Preparation%20and%20characterization%20of%20Poly.pdf |