Optimizing supercritical antisolvent process parameters to minimize the particle size of paracetamol nanoencapsulated in L-polylactide
Background: The aim of this study was to optimize the different process parameters including pressure, temperature, and polymer concentration, to produce fine small spherical particles with a narrow particle size distribution using a supercritical antisolvent method for drug encapsulation. The inter...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2011
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| Online Access: | http://psasir.upm.edu.my/id/eprint/22986/ http://psasir.upm.edu.my/id/eprint/22986/1/22986.pdf |
| _version_ | 1848844633371574272 |
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| author | Kalani, Mahshid Yunus, Robiah Abdullah, Norhafizah |
| author_facet | Kalani, Mahshid Yunus, Robiah Abdullah, Norhafizah |
| author_sort | Kalani, Mahshid |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Background: The aim of this study was to optimize the different process parameters including pressure, temperature, and polymer concentration, to produce fine small spherical particles with a narrow particle size distribution using a supercritical antisolvent method for drug encapsulation. The interaction between different process parameters was also investigated. Methods and results: The optimized process parameters resulted in production of nanoencapsulated paracetamol in L-polylactide with a mean diameter of approximately 300 nm at 120 bar, 30°C, and a polymer concentration of 16 ppm. Thermogravimetric analysis illustrated the thermal characteristics of the nanoparticles. The high electrical charge on the surface of the nanoparticles caused the particles to repel each other, with the high negative zeta potential preventing flocculation. Conclusion: Our results illustrate the effect of different process parameters on particle size and morphology, and validate results obtained via RSM statistical software. Furthermore, the in vitro drug-release profile is consistent with a Korsmeyer–Peppas kinetic model. |
| first_indexed | 2025-11-15T08:34:01Z |
| format | Article |
| id | upm-22986 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T08:34:01Z |
| publishDate | 2011 |
| publisher | Dove Medical Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-229862015-12-15T03:15:27Z http://psasir.upm.edu.my/id/eprint/22986/ Optimizing supercritical antisolvent process parameters to minimize the particle size of paracetamol nanoencapsulated in L-polylactide Kalani, Mahshid Yunus, Robiah Abdullah, Norhafizah Background: The aim of this study was to optimize the different process parameters including pressure, temperature, and polymer concentration, to produce fine small spherical particles with a narrow particle size distribution using a supercritical antisolvent method for drug encapsulation. The interaction between different process parameters was also investigated. Methods and results: The optimized process parameters resulted in production of nanoencapsulated paracetamol in L-polylactide with a mean diameter of approximately 300 nm at 120 bar, 30°C, and a polymer concentration of 16 ppm. Thermogravimetric analysis illustrated the thermal characteristics of the nanoparticles. The high electrical charge on the surface of the nanoparticles caused the particles to repel each other, with the high negative zeta potential preventing flocculation. Conclusion: Our results illustrate the effect of different process parameters on particle size and morphology, and validate results obtained via RSM statistical software. Furthermore, the in vitro drug-release profile is consistent with a Korsmeyer–Peppas kinetic model. Dove Medical Press 2011 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/22986/1/22986.pdf Kalani, Mahshid and Yunus, Robiah and Abdullah, Norhafizah (2011) Optimizing supercritical antisolvent process parameters to minimize the particle size of paracetamol nanoencapsulated in L-polylactide. International Journal of Nanomedicine, 6. pp. 1101-1105. ISSN 1176-9114; ESSN: 1178-2013 https://www.dovepress.com/optimizing-supercritical-antisolvent-process-parameters-to-minimize-th-peer-reviewed-article-IJN 10.2147/IJN.S18979 |
| spellingShingle | Kalani, Mahshid Yunus, Robiah Abdullah, Norhafizah Optimizing supercritical antisolvent process parameters to minimize the particle size of paracetamol nanoencapsulated in L-polylactide |
| title | Optimizing supercritical antisolvent process parameters to minimize the particle size of paracetamol nanoencapsulated in L-polylactide |
| title_full | Optimizing supercritical antisolvent process parameters to minimize the particle size of paracetamol nanoencapsulated in L-polylactide |
| title_fullStr | Optimizing supercritical antisolvent process parameters to minimize the particle size of paracetamol nanoencapsulated in L-polylactide |
| title_full_unstemmed | Optimizing supercritical antisolvent process parameters to minimize the particle size of paracetamol nanoencapsulated in L-polylactide |
| title_short | Optimizing supercritical antisolvent process parameters to minimize the particle size of paracetamol nanoencapsulated in L-polylactide |
| title_sort | optimizing supercritical antisolvent process parameters to minimize the particle size of paracetamol nanoencapsulated in l-polylactide |
| url | http://psasir.upm.edu.my/id/eprint/22986/ http://psasir.upm.edu.my/id/eprint/22986/ http://psasir.upm.edu.my/id/eprint/22986/ http://psasir.upm.edu.my/id/eprint/22986/1/22986.pdf |