Application of supercritical antisolvent method in drug encapsulation: a review
The review focuses on the application of supercritical fluids as antisolvents in the pharmaceutical field and demonstrates the supercritical antisolvent method in the use of drug encapsulation. The main factors for choosing the solvent and biodegradable polymer to produce fine particles to ensure ef...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2011
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| Online Access: | http://psasir.upm.edu.my/id/eprint/22985/ http://psasir.upm.edu.my/id/eprint/22985/1/22985.pdf |
| _version_ | 1848844633026592768 |
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| author | Kalani, Mahshid Yunus, Robiah |
| author_facet | Kalani, Mahshid Yunus, Robiah |
| author_sort | Kalani, Mahshid |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The review focuses on the application of supercritical fluids as antisolvents in the pharmaceutical field and demonstrates the supercritical antisolvent method in the use of drug encapsulation. The main factors for choosing the solvent and biodegradable polymer to produce fine particles to ensure effective drug delivery are emphasized and the effect of polymer structure on drug encapsulation is illustrated. The review also demonstrates the drug release mechanism and polymeric controlled release system, and discusses the effects of the various conditions in the process, such as pressure, temperature, concentration, chemical compositions (organic solvents, drug, and biodegradable polymer), nozzle geometry, CO2 flow rate, and the liquid phase flow rate on particle size and its distribution. |
| first_indexed | 2025-11-15T08:34:01Z |
| format | Article |
| id | upm-22985 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T08:34:01Z |
| publishDate | 2011 |
| publisher | Dove Medical Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-229852015-12-15T03:14:53Z http://psasir.upm.edu.my/id/eprint/22985/ Application of supercritical antisolvent method in drug encapsulation: a review Kalani, Mahshid Yunus, Robiah The review focuses on the application of supercritical fluids as antisolvents in the pharmaceutical field and demonstrates the supercritical antisolvent method in the use of drug encapsulation. The main factors for choosing the solvent and biodegradable polymer to produce fine particles to ensure effective drug delivery are emphasized and the effect of polymer structure on drug encapsulation is illustrated. The review also demonstrates the drug release mechanism and polymeric controlled release system, and discusses the effects of the various conditions in the process, such as pressure, temperature, concentration, chemical compositions (organic solvents, drug, and biodegradable polymer), nozzle geometry, CO2 flow rate, and the liquid phase flow rate on particle size and its distribution. Dove Medical Press 2011 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/22985/1/22985.pdf Kalani, Mahshid and Yunus, Robiah (2011) Application of supercritical antisolvent method in drug encapsulation: a review. International Journal of Nanomedicine, 6. pp. 1429-1442. ISSN 1176-9114; ESSN: 1178-2013 https://www.dovepress.com/application-of-supercritical-antisolvent-method-in-drug-encapsulation--peer-reviewed-article-IJN 10.2147/IJN.S19021 |
| spellingShingle | Kalani, Mahshid Yunus, Robiah Application of supercritical antisolvent method in drug encapsulation: a review |
| title | Application of supercritical antisolvent method in drug encapsulation: a review |
| title_full | Application of supercritical antisolvent method in drug encapsulation: a review |
| title_fullStr | Application of supercritical antisolvent method in drug encapsulation: a review |
| title_full_unstemmed | Application of supercritical antisolvent method in drug encapsulation: a review |
| title_short | Application of supercritical antisolvent method in drug encapsulation: a review |
| title_sort | application of supercritical antisolvent method in drug encapsulation: a review |
| url | http://psasir.upm.edu.my/id/eprint/22985/ http://psasir.upm.edu.my/id/eprint/22985/ http://psasir.upm.edu.my/id/eprint/22985/ http://psasir.upm.edu.my/id/eprint/22985/1/22985.pdf |