In vivo anti-nociceptive and anti-inflammatory activities of the aqueous extract of the leaves of Piper sarmentosum.
Ethnopharmacological relevance: Piper sarmentosum (Piperaceae) is a medicinal plant traditionally used by the Malays to treat headaches, toothaches, coughs, asthma and fever. Aim of the study: In order to establish the pharmacological properties of the leaf of this plant, studies were perfor...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English English |
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Elsevier
2010
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| Online Access: | http://psasir.upm.edu.my/id/eprint/15175/ http://psasir.upm.edu.my/id/eprint/15175/1/In%20vivo%20anti-nociceptive%20and%20anti-inflammatory%20activities%20of%20the%20aqueous%20extract%20of%20the%20leaves%20of%20Piper%20sarmentosum..pdf |
| _version_ | 1848842603321098240 |
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| author | Zakaria, Zainul Amiruddin Patahuddin, H. Tengku Mohamad, Tengku Azam Shah Israf Ali, Daud Ahmad Sulaiman, Mohd Roslan |
| author_facet | Zakaria, Zainul Amiruddin Patahuddin, H. Tengku Mohamad, Tengku Azam Shah Israf Ali, Daud Ahmad Sulaiman, Mohd Roslan |
| author_sort | Zakaria, Zainul Amiruddin |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Ethnopharmacological relevance:
Piper sarmentosum (Piperaceae) is a medicinal plant traditionally used by the Malays to treat headaches, toothaches, coughs, asthma and fever.
Aim of the study:
In order to establish the pharmacological properties of the leaf of this plant, studies were performed on anti-nociceptive and anti-inflammatory activities.
Materials and methods:
The aqueous extract of Piper sarmentosum (AEPS) was prepared in the doses of 30, 100 and 300 mg/kg. Anti-nociceptive activity of AEPS was evaluated by abdominal constriction and hot-plate tests. AEPS was also pre-challenged with 5 mg/kg naloxone to determine the involvement of opioid receptors. Anti-inflammatory activity was evaluated using carrageenan-induced paw edema assay.
Results:
Subcutaneous administration of AEPS exhibited anti-nociceptive activity (P<0.05) in a dose-dependent manner in the abdominal constriction and hot-plate tests. Pre-treatment with naloxone completely (P<0.05) diminished the extract anti-nociceptive activity in both tests. The AEPS, at all doses used, exerted significant (P<0.05) anti-inflammatory activity in a dose-dependent manner.
Conclusions:
The AEPS exhibits opioid-mediated anti-nociceptive activity at the peripheral and central levels, as well as anti-inflammatory activity, which confirmed the traditional uses of the plant in the treatment of pain- and inflammatory-related ailments. |
| first_indexed | 2025-11-15T08:01:45Z |
| format | Article |
| id | upm-15175 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T08:01:45Z |
| publishDate | 2010 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-151752015-11-24T04:10:31Z http://psasir.upm.edu.my/id/eprint/15175/ In vivo anti-nociceptive and anti-inflammatory activities of the aqueous extract of the leaves of Piper sarmentosum. Zakaria, Zainul Amiruddin Patahuddin, H. Tengku Mohamad, Tengku Azam Shah Israf Ali, Daud Ahmad Sulaiman, Mohd Roslan Ethnopharmacological relevance: Piper sarmentosum (Piperaceae) is a medicinal plant traditionally used by the Malays to treat headaches, toothaches, coughs, asthma and fever. Aim of the study: In order to establish the pharmacological properties of the leaf of this plant, studies were performed on anti-nociceptive and anti-inflammatory activities. Materials and methods: The aqueous extract of Piper sarmentosum (AEPS) was prepared in the doses of 30, 100 and 300 mg/kg. Anti-nociceptive activity of AEPS was evaluated by abdominal constriction and hot-plate tests. AEPS was also pre-challenged with 5 mg/kg naloxone to determine the involvement of opioid receptors. Anti-inflammatory activity was evaluated using carrageenan-induced paw edema assay. Results: Subcutaneous administration of AEPS exhibited anti-nociceptive activity (P<0.05) in a dose-dependent manner in the abdominal constriction and hot-plate tests. Pre-treatment with naloxone completely (P<0.05) diminished the extract anti-nociceptive activity in both tests. The AEPS, at all doses used, exerted significant (P<0.05) anti-inflammatory activity in a dose-dependent manner. Conclusions: The AEPS exhibits opioid-mediated anti-nociceptive activity at the peripheral and central levels, as well as anti-inflammatory activity, which confirmed the traditional uses of the plant in the treatment of pain- and inflammatory-related ailments. Elsevier 2010-03 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/15175/1/In%20vivo%20anti-nociceptive%20and%20anti-inflammatory%20activities%20of%20the%20aqueous%20extract%20of%20the%20leaves%20of%20Piper%20sarmentosum..pdf Zakaria, Zainul Amiruddin and Patahuddin, H. and Tengku Mohamad, Tengku Azam Shah and Israf Ali, Daud Ahmad and Sulaiman, Mohd Roslan (2010) In vivo anti-nociceptive and anti-inflammatory activities of the aqueous extract of the leaves of Piper sarmentosum. Journal of Ethnopharmacology, 128 (1). pp. 42-48. ISSN 0378-8741; ESSN: 1872-7573 http://www.elsevier.com 10.1016/j.jep.2009.12.021 English |
| spellingShingle | Zakaria, Zainul Amiruddin Patahuddin, H. Tengku Mohamad, Tengku Azam Shah Israf Ali, Daud Ahmad Sulaiman, Mohd Roslan In vivo anti-nociceptive and anti-inflammatory activities of the aqueous extract of the leaves of Piper sarmentosum. |
| title | In vivo anti-nociceptive and anti-inflammatory activities of the aqueous extract of the leaves of Piper sarmentosum. |
| title_full | In vivo anti-nociceptive and anti-inflammatory activities of the aqueous extract of the leaves of Piper sarmentosum. |
| title_fullStr | In vivo anti-nociceptive and anti-inflammatory activities of the aqueous extract of the leaves of Piper sarmentosum. |
| title_full_unstemmed | In vivo anti-nociceptive and anti-inflammatory activities of the aqueous extract of the leaves of Piper sarmentosum. |
| title_short | In vivo anti-nociceptive and anti-inflammatory activities of the aqueous extract of the leaves of Piper sarmentosum. |
| title_sort | in vivo anti-nociceptive and anti-inflammatory activities of the aqueous extract of the leaves of piper sarmentosum. |
| url | http://psasir.upm.edu.my/id/eprint/15175/ http://psasir.upm.edu.my/id/eprint/15175/ http://psasir.upm.edu.my/id/eprint/15175/ http://psasir.upm.edu.my/id/eprint/15175/1/In%20vivo%20anti-nociceptive%20and%20anti-inflammatory%20activities%20of%20the%20aqueous%20extract%20of%20the%20leaves%20of%20Piper%20sarmentosum..pdf |