C-511T polymorphism of interleukin-1 β gene is not associated in type 2 diabetes mellitus - a study in Malaysian population.
The objective of this study is to determine the association between the C-511T polymorphism of Interleukin -1 β gene in T2DM with or without hypertension in Malaysian population. A total of 175 subjects were recruited for this study. Genotyping of C-511T variant was performed by Hot-start PCR-RFLP a...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Asian Network for Scientific Information
2008
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/13469/ http://psasir.upm.edu.my/id/eprint/13469/1/C511T%20polymorphism%20of%20interleukin1%20%CE%B2%20gene%20is%20not%20associated%20in%20type%202%20diabetes%20mellitus%20%20a%20study%20in%20Malaysian%20population.pdf |
| _version_ | 1848842121118744576 |
|---|---|
| author | Vasudevan, Ramachandran Ismail, Patimah Stanslas, Johnson Shamsudin, Norashikin |
| author_facet | Vasudevan, Ramachandran Ismail, Patimah Stanslas, Johnson Shamsudin, Norashikin |
| author_sort | Vasudevan, Ramachandran |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The objective of this study is to determine the association between the C-511T polymorphism of Interleukin -1 β gene in T2DM with or without hypertension in Malaysian population. A total of 175 subjects were recruited for this study. Genotyping of C-511T variant was performed by Hot-start PCR-RFLP analysis. The frequency for CC, TC and TT genotypes of C-511T variant in IL-1 β gene was 25.45, 40 and 34.55% in T2DM 25, 51.67 and 23.33% in T2DM with hypertension and 21.66, 36.67 and 41.67% respectively found in controls (p>0.05). This study suggests that there was no significant difference in the genotypic distribution of C-511T polymorphism of IL-1 β gene between T2DM and controls. Therefore, C-511T variant in IL-1 β gene polymorphism is not considered an independent risk factor or not a predictor for T2DM in Malaysian population. |
| first_indexed | 2025-11-15T07:54:05Z |
| format | Article |
| id | upm-13469 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T07:54:05Z |
| publishDate | 2008 |
| publisher | Asian Network for Scientific Information |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-134692015-10-08T02:31:58Z http://psasir.upm.edu.my/id/eprint/13469/ C-511T polymorphism of interleukin-1 β gene is not associated in type 2 diabetes mellitus - a study in Malaysian population. Vasudevan, Ramachandran Ismail, Patimah Stanslas, Johnson Shamsudin, Norashikin The objective of this study is to determine the association between the C-511T polymorphism of Interleukin -1 β gene in T2DM with or without hypertension in Malaysian population. A total of 175 subjects were recruited for this study. Genotyping of C-511T variant was performed by Hot-start PCR-RFLP analysis. The frequency for CC, TC and TT genotypes of C-511T variant in IL-1 β gene was 25.45, 40 and 34.55% in T2DM 25, 51.67 and 23.33% in T2DM with hypertension and 21.66, 36.67 and 41.67% respectively found in controls (p>0.05). This study suggests that there was no significant difference in the genotypic distribution of C-511T polymorphism of IL-1 β gene between T2DM and controls. Therefore, C-511T variant in IL-1 β gene polymorphism is not considered an independent risk factor or not a predictor for T2DM in Malaysian population. Asian Network for Scientific Information 2008-04-01 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/13469/1/C511T%20polymorphism%20of%20interleukin1%20%CE%B2%20gene%20is%20not%20associated%20in%20type%202%20diabetes%20mellitus%20%20a%20study%20in%20Malaysian%20population.pdf Vasudevan, Ramachandran and Ismail, Patimah and Stanslas, Johnson and Shamsudin, Norashikin (2008) C-511T polymorphism of interleukin-1 β gene is not associated in type 2 diabetes mellitus - a study in Malaysian population. Journal of Medical Sciences, 8 (3). pp. 216-221. ISSN 1682-4474; ESSN : 1812-5727 http://scialert.net/abstract/?doi=jms.2008.216.221 10.3923/jms.2008.216.221 |
| spellingShingle | Vasudevan, Ramachandran Ismail, Patimah Stanslas, Johnson Shamsudin, Norashikin C-511T polymorphism of interleukin-1 β gene is not associated in type 2 diabetes mellitus - a study in Malaysian population. |
| title | C-511T polymorphism of interleukin-1 β gene is not associated in type 2 diabetes mellitus - a study in Malaysian population. |
| title_full | C-511T polymorphism of interleukin-1 β gene is not associated in type 2 diabetes mellitus - a study in Malaysian population. |
| title_fullStr | C-511T polymorphism of interleukin-1 β gene is not associated in type 2 diabetes mellitus - a study in Malaysian population. |
| title_full_unstemmed | C-511T polymorphism of interleukin-1 β gene is not associated in type 2 diabetes mellitus - a study in Malaysian population. |
| title_short | C-511T polymorphism of interleukin-1 β gene is not associated in type 2 diabetes mellitus - a study in Malaysian population. |
| title_sort | c-511t polymorphism of interleukin-1 β gene is not associated in type 2 diabetes mellitus - a study in malaysian population. |
| url | http://psasir.upm.edu.my/id/eprint/13469/ http://psasir.upm.edu.my/id/eprint/13469/ http://psasir.upm.edu.my/id/eprint/13469/ http://psasir.upm.edu.my/id/eprint/13469/1/C511T%20polymorphism%20of%20interleukin1%20%CE%B2%20gene%20is%20not%20associated%20in%20type%202%20diabetes%20mellitus%20%20a%20study%20in%20Malaysian%20population.pdf |