Bioactive sesquiterpenes from Curcuma ochrorhiza and Curcuma heyneana
Curcuma ochrorhiza ('temu putih') and C. heyneana ('temu giring') are two Zingiberaceous species which are commonly used in traditional medicine in Malaysia and Indonesia. Phytochemical investigations on these Curcuma species have resulted in the isolation of six sesquiterpenes,...
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| Format: | Article |
| Language: | English |
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Taylor & Francis
2010
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| Online Access: | http://psasir.upm.edu.my/id/eprint/13401/ http://psasir.upm.edu.my/id/eprint/13401/1/Bioactive%20sesquiterpenes%20from%20Curcuma%20ochrorhiza%20and%20Curcuma%20heyneana.pdf |
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| author | Md. Sukari, Mohd Aspollah Tang, Sook Wah Md Saad, Suhaila Rashid, Nur Yuhasliza Rahmani, Mawardi Lajis, Md. Nordin Yap, Taufiq Yun Hin |
| author_facet | Md. Sukari, Mohd Aspollah Tang, Sook Wah Md Saad, Suhaila Rashid, Nur Yuhasliza Rahmani, Mawardi Lajis, Md. Nordin Yap, Taufiq Yun Hin |
| author_sort | Md. Sukari, Mohd Aspollah |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Curcuma ochrorhiza ('temu putih') and C. heyneana ('temu giring') are two Zingiberaceous species which are commonly used in traditional medicine in Malaysia and Indonesia. Phytochemical investigations on these Curcuma species have resulted in the isolation of six sesquiterpenes, namely zerumbone (1), furanodienone (2), zederone (3), oxycurcumenol epoxide (4), curcumenol (5) and isocurcumenol (6), along with phytosterols stigmasterol and alpha-sitosterol. Compounds 1 and 2 were obtained for the first time for C. ochrorhiza while 4 was new to C. heyneana. The hexane extract of C. ochrorhiza and sesquiterpenes 1 and 3 showed very strong cytotoxicity activity against T-acute lymphoblastic leukaemia cells (CEM-SS), with IC(50) values of 6.0, 0.6 and 1.6 microg mL(-1), respectively. Meanwhile, constituents from C. heyneana (4-6) demonstrated moderate inhibition against CEM-SS in cytotoxic assay, with IC(50) values of 11.9, 12.6 and 13.3 microg mL(-1), respectively. The crude extracts and sesquiterpenes isolated were moderately active against certain bacteria tested in antimicrobial screening. |
| first_indexed | 2025-11-15T07:53:48Z |
| format | Article |
| id | upm-13401 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T07:53:48Z |
| publishDate | 2010 |
| publisher | Taylor & Francis |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-134012016-11-29T01:35:56Z http://psasir.upm.edu.my/id/eprint/13401/ Bioactive sesquiterpenes from Curcuma ochrorhiza and Curcuma heyneana Md. Sukari, Mohd Aspollah Tang, Sook Wah Md Saad, Suhaila Rashid, Nur Yuhasliza Rahmani, Mawardi Lajis, Md. Nordin Yap, Taufiq Yun Hin Curcuma ochrorhiza ('temu putih') and C. heyneana ('temu giring') are two Zingiberaceous species which are commonly used in traditional medicine in Malaysia and Indonesia. Phytochemical investigations on these Curcuma species have resulted in the isolation of six sesquiterpenes, namely zerumbone (1), furanodienone (2), zederone (3), oxycurcumenol epoxide (4), curcumenol (5) and isocurcumenol (6), along with phytosterols stigmasterol and alpha-sitosterol. Compounds 1 and 2 were obtained for the first time for C. ochrorhiza while 4 was new to C. heyneana. The hexane extract of C. ochrorhiza and sesquiterpenes 1 and 3 showed very strong cytotoxicity activity against T-acute lymphoblastic leukaemia cells (CEM-SS), with IC(50) values of 6.0, 0.6 and 1.6 microg mL(-1), respectively. Meanwhile, constituents from C. heyneana (4-6) demonstrated moderate inhibition against CEM-SS in cytotoxic assay, with IC(50) values of 11.9, 12.6 and 13.3 microg mL(-1), respectively. The crude extracts and sesquiterpenes isolated were moderately active against certain bacteria tested in antimicrobial screening. Taylor & Francis 2010-05-20 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/13401/1/Bioactive%20sesquiterpenes%20from%20Curcuma%20ochrorhiza%20and%20Curcuma%20heyneana.pdf Md. Sukari, Mohd Aspollah and Tang, Sook Wah and Md Saad, Suhaila and Rashid, Nur Yuhasliza and Rahmani, Mawardi and Lajis, Md. Nordin and Yap, Taufiq Yun Hin (2010) Bioactive sesquiterpenes from Curcuma ochrorhiza and Curcuma heyneana. Natural Product Research, 24 (9). pp. 838-845. ISSN 1478-6419; ESSN: 1029–2349 10.1080/14786410903052951 |
| spellingShingle | Md. Sukari, Mohd Aspollah Tang, Sook Wah Md Saad, Suhaila Rashid, Nur Yuhasliza Rahmani, Mawardi Lajis, Md. Nordin Yap, Taufiq Yun Hin Bioactive sesquiterpenes from Curcuma ochrorhiza and Curcuma heyneana |
| title | Bioactive sesquiterpenes from Curcuma ochrorhiza and Curcuma heyneana |
| title_full | Bioactive sesquiterpenes from Curcuma ochrorhiza and Curcuma heyneana |
| title_fullStr | Bioactive sesquiterpenes from Curcuma ochrorhiza and Curcuma heyneana |
| title_full_unstemmed | Bioactive sesquiterpenes from Curcuma ochrorhiza and Curcuma heyneana |
| title_short | Bioactive sesquiterpenes from Curcuma ochrorhiza and Curcuma heyneana |
| title_sort | bioactive sesquiterpenes from curcuma ochrorhiza and curcuma heyneana |
| url | http://psasir.upm.edu.my/id/eprint/13401/ http://psasir.upm.edu.my/id/eprint/13401/ http://psasir.upm.edu.my/id/eprint/13401/1/Bioactive%20sesquiterpenes%20from%20Curcuma%20ochrorhiza%20and%20Curcuma%20heyneana.pdf |