In Vitro evaluation of T- cell Acute Lymphoblastic Leukemia cell line response to a combination of dual anticancer agent: SRJ23 and Hydroxyurea
T-cell acute lymphoblastic leukemia (T-ALL) is a hostile haematologic neoplasm caused by a malignant transformation of immature progenitors of T-cells. Due to the variable response to conventional chemotherapy regimens available to-date, a holistic chemotherapy combination drugs with greater pre...
| Main Authors: | , , , |
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| Format: | Conference or Workshop Item |
| Language: | English |
| Published: |
2024
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| Online Access: | http://psasir.upm.edu.my/id/eprint/121122/ http://psasir.upm.edu.my/id/eprint/121122/1/121122.pdf |
| _version_ | 1848868297420832768 |
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| author | Khalid, Bahariah Karuppiah, Thilakavathy Stanslas, Johnson Marashdeh, Laith |
| author_facet | Khalid, Bahariah Karuppiah, Thilakavathy Stanslas, Johnson Marashdeh, Laith |
| author_sort | Khalid, Bahariah |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | T-cell acute lymphoblastic leukemia (T-ALL) is a hostile haematologic
neoplasm caused by a malignant transformation of immature
progenitors of T-cells. Due to the variable response to conventional
chemotherapy regimens available to-date, a holistic chemotherapy
combination drugs with greater precision to obtain the desired
results are worth studying. We aim to evaluate the inhibitory effect
of a readily available cyto-reducing agent, hydroxyurea (HU) with
SRJ23, on Jurkat cell line which are an immortalised of human T
lymphocyte cells to determine the efficacy in vitro. |
| first_indexed | 2025-11-15T14:50:09Z |
| format | Conference or Workshop Item |
| id | upm-121122 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T14:50:09Z |
| publishDate | 2024 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1211222025-10-28T00:37:21Z http://psasir.upm.edu.my/id/eprint/121122/ In Vitro evaluation of T- cell Acute Lymphoblastic Leukemia cell line response to a combination of dual anticancer agent: SRJ23 and Hydroxyurea Khalid, Bahariah Karuppiah, Thilakavathy Stanslas, Johnson Marashdeh, Laith T-cell acute lymphoblastic leukemia (T-ALL) is a hostile haematologic neoplasm caused by a malignant transformation of immature progenitors of T-cells. Due to the variable response to conventional chemotherapy regimens available to-date, a holistic chemotherapy combination drugs with greater precision to obtain the desired results are worth studying. We aim to evaluate the inhibitory effect of a readily available cyto-reducing agent, hydroxyurea (HU) with SRJ23, on Jurkat cell line which are an immortalised of human T lymphocyte cells to determine the efficacy in vitro. 2024 Conference or Workshop Item NonPeerReviewed image en http://psasir.upm.edu.my/id/eprint/121122/1/121122.pdf Khalid, Bahariah and Karuppiah, Thilakavathy and Stanslas, Johnson and Marashdeh, Laith (2024) In Vitro evaluation of T- cell Acute Lymphoblastic Leukemia cell line response to a combination of dual anticancer agent: SRJ23 and Hydroxyurea. In: 21st Malaysian Society of Haematology Annual Scientific Meeting, 18-20 Apr. 2024, Shangri-La Hotel in Kuala Lumpur. . (Unpublished) |
| spellingShingle | Khalid, Bahariah Karuppiah, Thilakavathy Stanslas, Johnson Marashdeh, Laith In Vitro evaluation of T- cell Acute Lymphoblastic Leukemia cell line response to a combination of dual anticancer agent: SRJ23 and Hydroxyurea |
| title | In Vitro evaluation of T- cell Acute Lymphoblastic Leukemia cell line response to a combination of dual anticancer agent: SRJ23 and Hydroxyurea |
| title_full | In Vitro evaluation of T- cell Acute Lymphoblastic Leukemia cell line response to a combination of dual anticancer agent: SRJ23 and Hydroxyurea |
| title_fullStr | In Vitro evaluation of T- cell Acute Lymphoblastic Leukemia cell line response to a combination of dual anticancer agent: SRJ23 and Hydroxyurea |
| title_full_unstemmed | In Vitro evaluation of T- cell Acute Lymphoblastic Leukemia cell line response to a combination of dual anticancer agent: SRJ23 and Hydroxyurea |
| title_short | In Vitro evaluation of T- cell Acute Lymphoblastic Leukemia cell line response to a combination of dual anticancer agent: SRJ23 and Hydroxyurea |
| title_sort | in vitro evaluation of t- cell acute lymphoblastic leukemia cell line response to a combination of dual anticancer agent: srj23 and hydroxyurea |
| url | http://psasir.upm.edu.my/id/eprint/121122/ http://psasir.upm.edu.my/id/eprint/121122/1/121122.pdf |