Identification of the anti-epileptic effect of speciogynine through molecular network-aided metabolite profiling of M. speciosa alkaloids using zebrafish
Mitragyna speciosa is a native plant to Southeast Asian countries, known its medicinal use as an analgesic and stimulant. Apart from the indole-type alkaloids, which have been shown to be responsible for its pharmacological properties, there is still limited information on other classes of compounds...
| Main Authors: | Garba, Suleiman Abubakar, Swain, Puspanjali, Shaari, Khozirah, Afzan, Adlin, Lee, Soo Yee, Kim, Cheol-Hee, Mohd Faudzi, Siti Munirah |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier B.V.
2025
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/120720/ http://psasir.upm.edu.my/id/eprint/120720/1/120720.pdf |
Similar Items
Quantitative analysis of selected alkaloids of Mitragyna speciosa using 1H quantitative nuclear magnetic resonance spectroscopy
by: Garba, Suleiman Abubakar, et al.
Published: (2024)
by: Garba, Suleiman Abubakar, et al.
Published: (2024)
Embryonic arsenic exposure triggers long-term behavioral impairment with metabolite alterations in zebrafish
by: Abu Bakar, Noraini, et al.
Published: (2022)
by: Abu Bakar, Noraini, et al.
Published: (2022)
Embryonic mercury exposure in zebrafish: alteration of metabolites and gene expression, related to visual and behavioral impairments
by: Abu Bakar, Noraini, et al.
Published: (2023)
by: Abu Bakar, Noraini, et al.
Published: (2023)
Mapping molecular networks within Clitoria ternatea Linn. against LPS-induced neuroinflammation in microglial cells, with molecular docking and in vivo toxicity assessment in zebrafish
by: Mat Zian, Nurul Farah Adni, et al.
Published: (2022)
by: Mat Zian, Nurul Farah Adni, et al.
Published: (2022)
Studies On The Chemistry, Anticholinesterase Activity And Toxicity Of Mitragyna Speciosa (Kratom) Alkaloids
by: Chear, Nelson Jeng Yeou
Published: (2024)
by: Chear, Nelson Jeng Yeou
Published: (2024)
In silico studies, X-ray diffraction analysis and biological investigation of fluorinated pyrrolylated-chalcones in zebrafish epilepsy models
by: Muhammad Syafiq, Akmal Mohd Fahmi, et al.
Published: (2023)
by: Muhammad Syafiq, Akmal Mohd Fahmi, et al.
Published: (2023)
In silico studies, X-ray diffraction analysis and biological investigation of fluorinated pyrrolylated-chalcones in zebrafish epilepsy models
by: Mohd Fahmi, Muhammad Syafiq Akmal, et al.
Published: (2023)
by: Mohd Fahmi, Muhammad Syafiq Akmal, et al.
Published: (2023)
Isolation of major alkaloids from Mitragyna Speciosa (Kratom) / Mohd Firdaus Ahmad Akhibi
by: Ahmad Akhibi, Mohd Firdaus
Published: (2008)
by: Ahmad Akhibi, Mohd Firdaus
Published: (2008)
The cellular toxicology of mitragynine, the
dominant alkaloid of the narcotic-like herb,
Mitragyna speciosa Korth
by: Saidin, Nor Aini, et al.
Published: (2015)
by: Saidin, Nor Aini, et al.
Published: (2015)
Anorectic effect, biochemical and hematological profiles of alkaloid extract from Mitragyna speciosa Korth. in rats
by: Ekkasit Kumarnsit,, et al.
Published: (2021)
by: Ekkasit Kumarnsit,, et al.
Published: (2021)
Antidepressant properties of mitragynine, an alkaloid isolated from mitragyna speciosa korth, in mice model of depression
by: Nasir, Farah Idayu
Published: (2013)
by: Nasir, Farah Idayu
Published: (2013)
Role of histone regulations and modifications in cognitive functions of mitragynine (a major indole alkaloid of mitragyna speciosa)
by: Radhakrishnan, Sonia Dhiya
Published: (2021)
by: Radhakrishnan, Sonia Dhiya
Published: (2021)
Preliminary insight on diarylpentanoids as potential antimalarials: In silico, in vitro pLDH and in vivo zebrafish toxicity assessment
by: Ramli, Amirah Hani, et al.
Published: (2024)
by: Ramli, Amirah Hani, et al.
Published: (2024)
Metabolite profiling of Christia vespertilionis leaf metabolome via molecular network approach
by: Norazhar, Anis Irfan, et al.
Published: (2021)
by: Norazhar, Anis Irfan, et al.
Published: (2021)
Profile of Parkia speciosa hassk metabolites extracted with SFE using FTIR- PCA method
by: Nik Abdul Rahman, Nik Norulaini, et al.
Published: (2011)
by: Nik Abdul Rahman, Nik Norulaini, et al.
Published: (2011)
A study on compliance to epileptic drug among
epileptic patient attending physician clinic HUSM
by: Shaaban, Juwita
Published: (2010)
by: Shaaban, Juwita
Published: (2010)
Volatile compounds and alkaloids from the aqueous extract of mitragyna speciosa and their in vitro and in vivo anti-inflammatory studies / Norsita Tohar
by: Norsita , Tohar
Published: (2016)
by: Norsita , Tohar
Published: (2016)
Volatile compounds and alkaloids from the aqueous extract of mitragyna speciosa and their in vitro and in vivo anti-inflammatory studies / Norsita Tohar
by: Norsita , Tohar
Published: (2016)
by: Norsita , Tohar
Published: (2016)
Studies Of Mitragynine, The Principle Alkaloid Of Mitragyna Speciosa Korth (Kratom) On Its Abuse And Addictive Properties In Rat Behavioural Models
by: Harun, Norsyifa
Published: (2016)
by: Harun, Norsyifa
Published: (2016)
Anti-epileptic drug toxicity in children
by: Choonara, Imti
Published: (2018)
by: Choonara, Imti
Published: (2018)
Anti-epileptic properties of terpineol extracted from Myristica fragrans Houtt. essential oil in the epileptic rat model.
by: Abdul Rahman, Mohd Amir Asyraf, et al.
Published: (2011)
by: Abdul Rahman, Mohd Amir Asyraf, et al.
Published: (2011)
Zebrafish embryotoxicity and teratogenic effects of Christia vespertilionis leaf extract
by: Norazhar, Anis Irfan, et al.
Published: (2022)
by: Norazhar, Anis Irfan, et al.
Published: (2022)
LCMS/MS metabolite profiling and analysis of acute toxicity effect of the ethanolic extract of Centella asiatica on zebrafish model
by: Zakaria, Fauziahanim, et al.
Published: (2019)
by: Zakaria, Fauziahanim, et al.
Published: (2019)
Development Of Identification
Technique By Ftir-Pca For
Supercritically Extracted Metabolites
From Parkia Speciosa (Hassk) Seeds
by: Zhari, Salman
Published: (2007)
by: Zhari, Salman
Published: (2007)
Lamotrigine and valproate pharmacokinetics interactions in epileptic patients
by: Lalic, M., et al.
Published: (2009)
by: Lalic, M., et al.
Published: (2009)
Plant toxins: alkaloids and their toxicities
by: Mohamad Azzeme, Azzreena, et al.
Published: (2019)
by: Mohamad Azzeme, Azzreena, et al.
Published: (2019)
Alkaloidal constituents of Tinospora crispa
by: Choudhary, M. Iqbal, et al.
Published: (2010)
by: Choudhary, M. Iqbal, et al.
Published: (2010)
Zebrafish phenotypic screen identifies novel Notch antagonists
by: Velaithan, Vithya, et al.
Published: (2017)
by: Velaithan, Vithya, et al.
Published: (2017)
Seizure characteristics and the use of anti-epileptic drugs in children and young people with brain tumours and epileptic seizures: Analysis of regional paediatric cancer service population.
by: Pilotto, Chiara, et al.
Published: (2018)
by: Pilotto, Chiara, et al.
Published: (2018)
Seizure characteristics and the use of anti-epileptic drugs in children and young people with brain tumours and epileptic seizures: analysis of regional paediatric cancer service population
by: Pilotto, C, et al.
Published: (2018)
by: Pilotto, C, et al.
Published: (2018)
Limited P-glycoprotein mediated efflux for anti-epileptic drugs.
by: Crowe, Andrew, et al.
Published: (2006)
by: Crowe, Andrew, et al.
Published: (2006)
Recognition of Sesquiterpenoids and Piperidine Alkamides as Two Discerning Metabolite Classes in the Fruits of Piper nigrum 'Semongok Aman'
by: Osman, Muhamad Faris, et al.
Published: (2025)
by: Osman, Muhamad Faris, et al.
Published: (2025)
Vinca alkaloids
by: Moudi, Maryam, et al.
Published: (2013)
by: Moudi, Maryam, et al.
Published: (2013)
Artifact processing of Epileptic EEG Signals:
an overview of different types artifacts
by: Hamal, Abdul Qayoom, et al.
Published: (2013)
by: Hamal, Abdul Qayoom, et al.
Published: (2013)
Flat electroencephalography’s cluster centers movement tracking during epileptic seizure
by: Mukhni, Syu’aiba, et al.
Published: (2018)
by: Mukhni, Syu’aiba, et al.
Published: (2018)
An Enhanced Wavelet Neural Network Model For Epileptic Seizure Detection And Prediction
by: Lai , Kee Huong
Published: (2016)
by: Lai , Kee Huong
Published: (2016)
Reliable epileptic seizure detection using an improved wavelet neural network
by: Zainuddin, Zarita, et al.
Published: (2013)
by: Zainuddin, Zarita, et al.
Published: (2013)
A harmony search-based learning algorithm for epileptic seizure prediction
by: Kee, Huong Lai, et al.
Published: (2016)
by: Kee, Huong Lai, et al.
Published: (2016)
Alkaloids from Piper sarmentosum and Piper nigrum
by: Ee, Gwendoline Cheng Lian, et al.
Published: (2009)
by: Ee, Gwendoline Cheng Lian, et al.
Published: (2009)
Approximate Entropy-Based Epileptic EEG Detection Using Artificial Neural Networks
by: Srinivasan, Vairavan, et al.
Published: (2007)
by: Srinivasan, Vairavan, et al.
Published: (2007)
Similar Items
-
Quantitative analysis of selected alkaloids of Mitragyna speciosa using 1H quantitative nuclear magnetic resonance spectroscopy
by: Garba, Suleiman Abubakar, et al.
Published: (2024) -
Embryonic arsenic exposure triggers long-term behavioral impairment with metabolite alterations in zebrafish
by: Abu Bakar, Noraini, et al.
Published: (2022) -
Embryonic mercury exposure in zebrafish: alteration of metabolites and gene expression, related to visual and behavioral impairments
by: Abu Bakar, Noraini, et al.
Published: (2023) -
Mapping molecular networks within Clitoria ternatea Linn. against LPS-induced neuroinflammation in microglial cells, with molecular docking and in vivo toxicity assessment in zebrafish
by: Mat Zian, Nurul Farah Adni, et al.
Published: (2022) -
Studies On The Chemistry, Anticholinesterase Activity And Toxicity Of Mitragyna Speciosa (Kratom) Alkaloids
by: Chear, Nelson Jeng Yeou
Published: (2024)