Dowling-Degos disease: a case report and clinicopathological correlation of a rare genodermatosis
Dowling-Degos disease (DDD), also termed reticulate pigmented anomaly of the flexure, is a rare genodermatosis characterized by reticulate pigment macules, typically appearing after puberty. We describe a male patient, age 55, who has hyperpigmented papules and macules over the nape of his neck and...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
2024
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/120292/ http://psasir.upm.edu.my/id/eprint/120292/1/120292.pdf |
| _version_ | 1848868155389116416 |
|---|---|
| author | Lai, Shau Kong Mohd Nasir, Noor 'ain Wan Ahmad Kammal, Wan Syahira Ellani Abu, Nasiha Tak, Nor Akmar Tan, Yi Jun |
| author_facet | Lai, Shau Kong Mohd Nasir, Noor 'ain Wan Ahmad Kammal, Wan Syahira Ellani Abu, Nasiha Tak, Nor Akmar Tan, Yi Jun |
| author_sort | Lai, Shau Kong |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Dowling-Degos disease (DDD), also termed reticulate pigmented anomaly of the flexure, is a rare genodermatosis characterized by reticulate pigment macules, typically appearing after puberty. We describe a male patient, age 55, who has hyperpigmented papules and macules over the nape of his neck and flexures. The condition was initially diagnosed as lichen planus pigmentosus and has persisted for the past three years. Family history revealed similar skin conditions in maternal siblings and their mother. Skin biopsy demonstrated epidermal changes consistent with DDD, including filiform down-growth epidermis, thinning of suprapapillary plates, and basal layer hyperpigmentation. We discussed the broad differential diagnoses that mimic this condition. Correlating clinical, pathological, and genetic features is essential for its diagnosis. As this genodermatosis is typically resistant to treatment, specific therapies such as laser treatments have shown promise in managing DDD. This emphasizes the importance of correct diagnosis. |
| first_indexed | 2025-11-15T14:47:54Z |
| format | Article |
| id | upm-120292 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T14:47:54Z |
| publishDate | 2024 |
| publisher | Faculty of Medicine and Health Sciences, Universiti Putra Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1202922025-09-29T09:20:17Z http://psasir.upm.edu.my/id/eprint/120292/ Dowling-Degos disease: a case report and clinicopathological correlation of a rare genodermatosis Lai, Shau Kong Mohd Nasir, Noor 'ain Wan Ahmad Kammal, Wan Syahira Ellani Abu, Nasiha Tak, Nor Akmar Tan, Yi Jun Dowling-Degos disease (DDD), also termed reticulate pigmented anomaly of the flexure, is a rare genodermatosis characterized by reticulate pigment macules, typically appearing after puberty. We describe a male patient, age 55, who has hyperpigmented papules and macules over the nape of his neck and flexures. The condition was initially diagnosed as lichen planus pigmentosus and has persisted for the past three years. Family history revealed similar skin conditions in maternal siblings and their mother. Skin biopsy demonstrated epidermal changes consistent with DDD, including filiform down-growth epidermis, thinning of suprapapillary plates, and basal layer hyperpigmentation. We discussed the broad differential diagnoses that mimic this condition. Correlating clinical, pathological, and genetic features is essential for its diagnosis. As this genodermatosis is typically resistant to treatment, specific therapies such as laser treatments have shown promise in managing DDD. This emphasizes the importance of correct diagnosis. Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 2024-12 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/120292/1/120292.pdf Lai, Shau Kong and Mohd Nasir, Noor 'ain and Wan Ahmad Kammal, Wan Syahira Ellani and Abu, Nasiha and Tak, Nor Akmar and Tan, Yi Jun (2024) Dowling-Degos disease: a case report and clinicopathological correlation of a rare genodermatosis. Malaysian Journal of Medicine and Health Sciences, 20 (suppl. 11). art. no. 18. pp. 99-101. ISSN 2636-9346 https://medic.upm.edu.my/upload/dokumen/2024123018325519_MJMHS_1073.pdf 10.47836/mjmhs.20.s11.19 |
| spellingShingle | Lai, Shau Kong Mohd Nasir, Noor 'ain Wan Ahmad Kammal, Wan Syahira Ellani Abu, Nasiha Tak, Nor Akmar Tan, Yi Jun Dowling-Degos disease: a case report and clinicopathological correlation of a rare genodermatosis |
| title | Dowling-Degos disease: a case report and clinicopathological correlation of a rare genodermatosis |
| title_full | Dowling-Degos disease: a case report and clinicopathological correlation of a rare genodermatosis |
| title_fullStr | Dowling-Degos disease: a case report and clinicopathological correlation of a rare genodermatosis |
| title_full_unstemmed | Dowling-Degos disease: a case report and clinicopathological correlation of a rare genodermatosis |
| title_short | Dowling-Degos disease: a case report and clinicopathological correlation of a rare genodermatosis |
| title_sort | dowling-degos disease: a case report and clinicopathological correlation of a rare genodermatosis |
| url | http://psasir.upm.edu.my/id/eprint/120292/ http://psasir.upm.edu.my/id/eprint/120292/ http://psasir.upm.edu.my/id/eprint/120292/ http://psasir.upm.edu.my/id/eprint/120292/1/120292.pdf |