Neuroprotective roles of flavonoid “hispidulin” in the central nervous system: a review
Interest in naturally occurring phytochemicals has been on the increase, they are believed to reduce the risk of brain disorders. Hispidulin (HN) is a phenolic flavonoid compound with various pharmacological and biological effects on the central nervous system. It belongs to the flavone class of fla...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2024
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| Online Access: | http://psasir.upm.edu.my/id/eprint/119634/ http://psasir.upm.edu.my/id/eprint/119634/1/119634.pdf |
| _version_ | 1848868024734449664 |
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| author | Mustapha, Saeed Magaji, Rabiu Abdussalam Magaji, Mohammed Garba Gaya, Ibrahim Bako Umar, Baraka Yusha’u, Yusuf Daku, Abubakar Bishir Chiroma, Samaila Musa Jaafar, Aliyu Mehat, Mohamad Zulfadli Mat Taib, Che Norma Moh’d Moklas, Mohamad Aris |
| author_facet | Mustapha, Saeed Magaji, Rabiu Abdussalam Magaji, Mohammed Garba Gaya, Ibrahim Bako Umar, Baraka Yusha’u, Yusuf Daku, Abubakar Bishir Chiroma, Samaila Musa Jaafar, Aliyu Mehat, Mohamad Zulfadli Mat Taib, Che Norma Moh’d Moklas, Mohamad Aris |
| author_sort | Mustapha, Saeed |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Interest in naturally occurring phytochemicals has been on the increase, they are believed to reduce the risk of brain disorders. Hispidulin (HN) is a phenolic flavonoid compound with various pharmacological and biological effects on the central nervous system. It belongs to the flavone class of flavonoids. It can be found in different plant materials, especially fruits and vegetables. The literature used in this review was collected from credible scientific databases including ScienceDirect, Scopus, PubMed, Google Scholar, and Hindawi without time restriction, using relevant keywords, such as HN, brain, central nervous system, flavonoids, and flavones. HN was discovered to possess pro-apoptotic properties, act as an antioxidant, inhibit cytokine production and toll-like receptor 4 expression, as well as impede nuclear factor kappa beta and mitogen-activated protein kinase B. HN was also found to inhibit lipid peroxidation in vitro and reduce brain edema in mice. These pharmacological potentials suggest that HN is a promising candidate for neuroprotection in CNS disorders like depression and epilepsy. This review provides an update on the scientific literature concerning how these activities could help provide various forms of neuroprotection in the CNS. Additional experimental data on the effects of HN in models of neurological disorders and neuroprotection should be explored further. Based on the current study, HN is a promising candidate for neuroprotection of the CNS. |
| first_indexed | 2025-11-15T14:45:49Z |
| format | Article |
| id | upm-119634 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T14:45:49Z |
| publishDate | 2024 |
| publisher | Mashhad University of Medical Sciences |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1196342025-09-02T02:47:28Z http://psasir.upm.edu.my/id/eprint/119634/ Neuroprotective roles of flavonoid “hispidulin” in the central nervous system: a review Mustapha, Saeed Magaji, Rabiu Abdussalam Magaji, Mohammed Garba Gaya, Ibrahim Bako Umar, Baraka Yusha’u, Yusuf Daku, Abubakar Bishir Chiroma, Samaila Musa Jaafar, Aliyu Mehat, Mohamad Zulfadli Mat Taib, Che Norma Moh’d Moklas, Mohamad Aris Interest in naturally occurring phytochemicals has been on the increase, they are believed to reduce the risk of brain disorders. Hispidulin (HN) is a phenolic flavonoid compound with various pharmacological and biological effects on the central nervous system. It belongs to the flavone class of flavonoids. It can be found in different plant materials, especially fruits and vegetables. The literature used in this review was collected from credible scientific databases including ScienceDirect, Scopus, PubMed, Google Scholar, and Hindawi without time restriction, using relevant keywords, such as HN, brain, central nervous system, flavonoids, and flavones. HN was discovered to possess pro-apoptotic properties, act as an antioxidant, inhibit cytokine production and toll-like receptor 4 expression, as well as impede nuclear factor kappa beta and mitogen-activated protein kinase B. HN was also found to inhibit lipid peroxidation in vitro and reduce brain edema in mice. These pharmacological potentials suggest that HN is a promising candidate for neuroprotection in CNS disorders like depression and epilepsy. This review provides an update on the scientific literature concerning how these activities could help provide various forms of neuroprotection in the CNS. Additional experimental data on the effects of HN in models of neurological disorders and neuroprotection should be explored further. Based on the current study, HN is a promising candidate for neuroprotection of the CNS. Mashhad University of Medical Sciences 2024-09 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/119634/1/119634.pdf Mustapha, Saeed and Magaji, Rabiu Abdussalam and Magaji, Mohammed Garba and Gaya, Ibrahim Bako and Umar, Baraka and Yusha’u, Yusuf and Daku, Abubakar Bishir and Chiroma, Samaila Musa and Jaafar, Aliyu and Mehat, Mohamad Zulfadli and Mat Taib, Che Norma and Moh’d Moklas, Mohamad Aris (2024) Neuroprotective roles of flavonoid “hispidulin” in the central nervous system: a review. Iranian Journal of Basic Medical Sciences, 27 (9). pp. 1077-1084. ISSN 2008-3866; eISSN: 2008-3874 https://ijbms.mums.ac.ir/article_24286.html 10.22038/IJBMS.2024.76605.16573 |
| spellingShingle | Mustapha, Saeed Magaji, Rabiu Abdussalam Magaji, Mohammed Garba Gaya, Ibrahim Bako Umar, Baraka Yusha’u, Yusuf Daku, Abubakar Bishir Chiroma, Samaila Musa Jaafar, Aliyu Mehat, Mohamad Zulfadli Mat Taib, Che Norma Moh’d Moklas, Mohamad Aris Neuroprotective roles of flavonoid “hispidulin” in the central nervous system: a review |
| title | Neuroprotective roles of flavonoid “hispidulin” in the central nervous system: a review |
| title_full | Neuroprotective roles of flavonoid “hispidulin” in the central nervous system: a review |
| title_fullStr | Neuroprotective roles of flavonoid “hispidulin” in the central nervous system: a review |
| title_full_unstemmed | Neuroprotective roles of flavonoid “hispidulin” in the central nervous system: a review |
| title_short | Neuroprotective roles of flavonoid “hispidulin” in the central nervous system: a review |
| title_sort | neuroprotective roles of flavonoid “hispidulin” in the central nervous system: a review |
| url | http://psasir.upm.edu.my/id/eprint/119634/ http://psasir.upm.edu.my/id/eprint/119634/ http://psasir.upm.edu.my/id/eprint/119634/ http://psasir.upm.edu.my/id/eprint/119634/1/119634.pdf |