The mechanism underlying streptozotocin injection for the development of a nontransgenic Alzheimer’s disease animal model
Streptozotocin (STZ) is a widely used chemical agent in biomedical research. It is primarily known for its ability to induce high blood glucose levels in animal models by selectively destroying pancreatic beta cells. Nonetheless, many studies have also used STZ to generate animal models of diabetic...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Faculty of Veterinary Medicine, University of Tripoli
2025
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| Online Access: | http://psasir.upm.edu.my/id/eprint/118882/ http://psasir.upm.edu.my/id/eprint/118882/1/118882.pdf |
| _version_ | 1848867812765859840 |
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| author | Titisari, Nurina Ahmad, Hafandi Samsulrizal, Nurdiana Fauzi, Ahmad Abdul Razak, Intan Shameha |
| author_facet | Titisari, Nurina Ahmad, Hafandi Samsulrizal, Nurdiana Fauzi, Ahmad Abdul Razak, Intan Shameha |
| author_sort | Titisari, Nurina |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Streptozotocin (STZ) is a widely used chemical agent in biomedical research. It is primarily known for its ability to induce high blood glucose levels in animal models by selectively destroying pancreatic beta cells. Nonetheless, many studies have also used STZ to generate animal models of diabetic complications, such as Alzheimer’s disease (AD) animal models. STZ induction promotes hyperglycemia, which activates numerous mechanism pathways that result in the production of pathogenic AD characteristics, including beta-amyloid accumulation and neurofibrillary tangles. Numerous theories exist to elucidate the mechanisms underlying diabetes and AD; however, studies on the potential of an animal model of STZ-induced AD remain limited. Thus, this review summarizes the pathogenesis associated with STZ exposure, particularly in AD animal model studies related to diabetes. More specifically, this study will discuss the relationship between increased blood glucose levels after STZ injection and the process of beta-amyloid formation and insulin dysfunction in the brain. |
| first_indexed | 2025-11-15T14:42:27Z |
| format | Article |
| id | upm-118882 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T14:42:27Z |
| publishDate | 2025 |
| publisher | Faculty of Veterinary Medicine, University of Tripoli |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1188822025-07-29T01:52:42Z http://psasir.upm.edu.my/id/eprint/118882/ The mechanism underlying streptozotocin injection for the development of a nontransgenic Alzheimer’s disease animal model Titisari, Nurina Ahmad, Hafandi Samsulrizal, Nurdiana Fauzi, Ahmad Abdul Razak, Intan Shameha Streptozotocin (STZ) is a widely used chemical agent in biomedical research. It is primarily known for its ability to induce high blood glucose levels in animal models by selectively destroying pancreatic beta cells. Nonetheless, many studies have also used STZ to generate animal models of diabetic complications, such as Alzheimer’s disease (AD) animal models. STZ induction promotes hyperglycemia, which activates numerous mechanism pathways that result in the production of pathogenic AD characteristics, including beta-amyloid accumulation and neurofibrillary tangles. Numerous theories exist to elucidate the mechanisms underlying diabetes and AD; however, studies on the potential of an animal model of STZ-induced AD remain limited. Thus, this review summarizes the pathogenesis associated with STZ exposure, particularly in AD animal model studies related to diabetes. More specifically, this study will discuss the relationship between increased blood glucose levels after STZ injection and the process of beta-amyloid formation and insulin dysfunction in the brain. Faculty of Veterinary Medicine, University of Tripoli 2025 Article PeerReviewed text en cc_by_nc_4 http://psasir.upm.edu.my/id/eprint/118882/1/118882.pdf Titisari, Nurina and Ahmad, Hafandi and Samsulrizal, Nurdiana and Fauzi, Ahmad and Abdul Razak, Intan Shameha (2025) The mechanism underlying streptozotocin injection for the development of a nontransgenic Alzheimer’s disease animal model. Open Veterinary Journal, 15 (2). pp. 594-600. ISSN 2226-4485; eISSN: 2218-6050 https://www.ejmanager.com/fulltextpdf.php?mno=231126 10.5455/OVJ.2025.v15.i2.8 |
| spellingShingle | Titisari, Nurina Ahmad, Hafandi Samsulrizal, Nurdiana Fauzi, Ahmad Abdul Razak, Intan Shameha The mechanism underlying streptozotocin injection for the development of a nontransgenic Alzheimer’s disease animal model |
| title | The mechanism underlying streptozotocin injection for the development of a nontransgenic Alzheimer’s disease animal model |
| title_full | The mechanism underlying streptozotocin injection for the development of a nontransgenic Alzheimer’s disease animal model |
| title_fullStr | The mechanism underlying streptozotocin injection for the development of a nontransgenic Alzheimer’s disease animal model |
| title_full_unstemmed | The mechanism underlying streptozotocin injection for the development of a nontransgenic Alzheimer’s disease animal model |
| title_short | The mechanism underlying streptozotocin injection for the development of a nontransgenic Alzheimer’s disease animal model |
| title_sort | mechanism underlying streptozotocin injection for the development of a nontransgenic alzheimer’s disease animal model |
| url | http://psasir.upm.edu.my/id/eprint/118882/ http://psasir.upm.edu.my/id/eprint/118882/ http://psasir.upm.edu.my/id/eprint/118882/ http://psasir.upm.edu.my/id/eprint/118882/1/118882.pdf |