Transient prenatal ruxolitinib treatment promotes neurogenesis and suppresses astrogliogenesis during embryonic mouse brain development

Transient prenatal ruxolitinib treatment promotes neurogenesis and suppresses astrogliogenesis during embryonic mouse brain development

Ruxolitinib is a Janus kinase (JAK) inhibitor that inhibits the JAK/STAT signalling pathway by targeting JAK1 and JAK2, which are crucial for regulating astrogliogenesis. This study assessed the effect of ruxolitinib (5 and 30 mg/kg/day) on developing mouse brains by administering it to pregnant mic...

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Bibliographic Details
Main Authors: Abdullah, Amirah Nabilah, Fasihah Zamri, Auni, Alias, Khairunnisa, Azhar, Nur Munawwarah, Ling, King Hwa, Cheah, Pike See, Zainal Abidin, Shahidee
Format: Article
Language:English
Published: Neurotak Publishing 2025
Online Access:http://psasir.upm.edu.my/id/eprint/118733/
http://psasir.upm.edu.my/id/eprint/118733/1/118733.pdf

Internet

http://psasir.upm.edu.my/id/eprint/118733/
http://psasir.upm.edu.my/id/eprint/118733/1/118733.pdf

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