Improved solubility and bioavailability of cyclolinopeptides by diacylglycerol in the β-cyclodextrin Pickering emulsions
Cyclolinopeptides (CLs) have anti-inflammatory, anti-osteoporosis, and anti-tumor effects, however, low water and oil solubility greatly limit their application. Herein, CLs-loaded β-cyclodextrin (β-CD) emulsions were prepared with different oil phases. The in vitro digestibility, cellular absorptio...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier Ltd
2025
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| Online Access: | http://psasir.upm.edu.my/id/eprint/118709/ http://psasir.upm.edu.my/id/eprint/118709/1/118709.pdf |
| _version_ | 1848867579406319616 |
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| author | Liu, Zhongbo Lee, Yee Ying Tan, Chin Ping Wang, Yong Qiu, Chaoying |
| author_facet | Liu, Zhongbo Lee, Yee Ying Tan, Chin Ping Wang, Yong Qiu, Chaoying |
| author_sort | Liu, Zhongbo |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Cyclolinopeptides (CLs) have anti-inflammatory, anti-osteoporosis, and anti-tumor effects, however, low water and oil solubility greatly limit their application. Herein, CLs-loaded β-cyclodextrin (β-CD) emulsions were prepared with different oil phases. The in vitro digestibility, cellular absorption, and anti-inflammatory effects were evaluated. Camellia oil diacylglycerol (CO DAG) showed enhanced dissolving ability for CLs due to high polarity. β-CD formed inclusion complexes with DAG through hydrogen bond and the emulsions showed smaller size and higher physical stability with 50 % (w/w) oil. The in vitro digestibility of the DAG emulsion was increased and the CLs' bioavailability was 13.6–fold higher than CLs in oil. The CLs–loaded Pickering emulsion digesta exhibited a higher nitric oxides (NO) inhibition rate (58.62 %) and Caco-2 cell penetration (3.09 × 10−6 cm/s). Therefore, emulsion formulated with β-cyclodextrin and DAG can effectively improve the solubility and bioavailability of CLs, which has significant potential for application in functional foods and pharmaceutical industry. |
| first_indexed | 2025-11-15T14:38:44Z |
| format | Article |
| id | upm-118709 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T14:38:44Z |
| publishDate | 2025 |
| publisher | Elsevier Ltd |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1187092025-07-22T07:17:35Z http://psasir.upm.edu.my/id/eprint/118709/ Improved solubility and bioavailability of cyclolinopeptides by diacylglycerol in the β-cyclodextrin Pickering emulsions Liu, Zhongbo Lee, Yee Ying Tan, Chin Ping Wang, Yong Qiu, Chaoying Cyclolinopeptides (CLs) have anti-inflammatory, anti-osteoporosis, and anti-tumor effects, however, low water and oil solubility greatly limit their application. Herein, CLs-loaded β-cyclodextrin (β-CD) emulsions were prepared with different oil phases. The in vitro digestibility, cellular absorption, and anti-inflammatory effects were evaluated. Camellia oil diacylglycerol (CO DAG) showed enhanced dissolving ability for CLs due to high polarity. β-CD formed inclusion complexes with DAG through hydrogen bond and the emulsions showed smaller size and higher physical stability with 50 % (w/w) oil. The in vitro digestibility of the DAG emulsion was increased and the CLs' bioavailability was 13.6–fold higher than CLs in oil. The CLs–loaded Pickering emulsion digesta exhibited a higher nitric oxides (NO) inhibition rate (58.62 %) and Caco-2 cell penetration (3.09 × 10−6 cm/s). Therefore, emulsion formulated with β-cyclodextrin and DAG can effectively improve the solubility and bioavailability of CLs, which has significant potential for application in functional foods and pharmaceutical industry. Elsevier Ltd 2025-02-01 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/118709/1/118709.pdf Liu, Zhongbo and Lee, Yee Ying and Tan, Chin Ping and Wang, Yong and Qiu, Chaoying (2025) Improved solubility and bioavailability of cyclolinopeptides by diacylglycerol in the β-cyclodextrin Pickering emulsions. Food Chemistry, 464. art. no. 141553. pp. 1-12. ISSN 0308-8146; eISSN: 1873-7072 https://linkinghub.elsevier.com/retrieve/pii/S0308814624032035 10.1016/j.foodchem.2024.141553 |
| spellingShingle | Liu, Zhongbo Lee, Yee Ying Tan, Chin Ping Wang, Yong Qiu, Chaoying Improved solubility and bioavailability of cyclolinopeptides by diacylglycerol in the β-cyclodextrin Pickering emulsions |
| title | Improved solubility and bioavailability of cyclolinopeptides by diacylglycerol in the β-cyclodextrin Pickering emulsions |
| title_full | Improved solubility and bioavailability of cyclolinopeptides by diacylglycerol in the β-cyclodextrin Pickering emulsions |
| title_fullStr | Improved solubility and bioavailability of cyclolinopeptides by diacylglycerol in the β-cyclodextrin Pickering emulsions |
| title_full_unstemmed | Improved solubility and bioavailability of cyclolinopeptides by diacylglycerol in the β-cyclodextrin Pickering emulsions |
| title_short | Improved solubility and bioavailability of cyclolinopeptides by diacylglycerol in the β-cyclodextrin Pickering emulsions |
| title_sort | improved solubility and bioavailability of cyclolinopeptides by diacylglycerol in the β-cyclodextrin pickering emulsions |
| url | http://psasir.upm.edu.my/id/eprint/118709/ http://psasir.upm.edu.my/id/eprint/118709/ http://psasir.upm.edu.my/id/eprint/118709/ http://psasir.upm.edu.my/id/eprint/118709/1/118709.pdf |