1H NMR-metabolomics studies on acute toxicity effect of lead in adult zebrafish (Danio rerio) model
Zebrafish (Danio rerio) is ideal for studying the effects of toxins like lead or plumbum (Pb) which persist in the environment and harm body systems when absorbed. Increasing Pb concentration could result in a higher mortality rate and alteration of behavior and metabolism. The present study evaluat...
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| Format: | Article |
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Taylor & Francis
2024
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| Online Access: | http://psasir.upm.edu.my/id/eprint/118255/ |
| _version_ | 1848867471174402048 |
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| author | Chong, Siok Geok Ismail, Intan Safinar Chong, Chou Min Mad Nasir, Nadiah Saleh Hodin, Nur Atikah |
| author_facet | Chong, Siok Geok Ismail, Intan Safinar Chong, Chou Min Mad Nasir, Nadiah Saleh Hodin, Nur Atikah |
| author_sort | Chong, Siok Geok |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Zebrafish (Danio rerio) is ideal for studying the effects of toxins like lead or plumbum (Pb) which persist in the environment and harm body systems when absorbed. Increasing Pb concentration could result in a higher mortality rate and alteration of behavior and metabolism. The present study evaluates the acute toxicity effect of Pb on metabolome and behavior in adult zebrafish. The zebrafish were exposed to various Pb concentrations ranging from 0 to 30 mg/L for different periods (24, 48, and 72 h) before the fish samples were subjected to Nuclear Magnetic Resonance (NMR)-multivariate data analysis (MVDA) with additional support from behavioral assessment. The behavior of zebrafish was significantly altered after Pb inducement and the differential metabolites increased in low (5 mg/L) while decreased in high (10 mg/L) Pb concentrations. An ideal Pb induction could be achieved by 5 mg/L concentration in 24 h, which induced significant metabolite changes without irreversible damage. Continuing research on the effects of lead toxicity is crucial to develop effective prevention and treatment strategies. |
| first_indexed | 2025-11-15T14:37:01Z |
| format | Article |
| id | upm-118255 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T14:37:01Z |
| publishDate | 2024 |
| publisher | Taylor & Francis |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1182552025-07-02T03:37:41Z http://psasir.upm.edu.my/id/eprint/118255/ 1H NMR-metabolomics studies on acute toxicity effect of lead in adult zebrafish (Danio rerio) model Chong, Siok Geok Ismail, Intan Safinar Chong, Chou Min Mad Nasir, Nadiah Saleh Hodin, Nur Atikah Zebrafish (Danio rerio) is ideal for studying the effects of toxins like lead or plumbum (Pb) which persist in the environment and harm body systems when absorbed. Increasing Pb concentration could result in a higher mortality rate and alteration of behavior and metabolism. The present study evaluates the acute toxicity effect of Pb on metabolome and behavior in adult zebrafish. The zebrafish were exposed to various Pb concentrations ranging from 0 to 30 mg/L for different periods (24, 48, and 72 h) before the fish samples were subjected to Nuclear Magnetic Resonance (NMR)-multivariate data analysis (MVDA) with additional support from behavioral assessment. The behavior of zebrafish was significantly altered after Pb inducement and the differential metabolites increased in low (5 mg/L) while decreased in high (10 mg/L) Pb concentrations. An ideal Pb induction could be achieved by 5 mg/L concentration in 24 h, which induced significant metabolite changes without irreversible damage. Continuing research on the effects of lead toxicity is crucial to develop effective prevention and treatment strategies. Taylor & Francis 2024-05-10 Article PeerReviewed Chong, Siok Geok and Ismail, Intan Safinar and Chong, Chou Min and Mad Nasir, Nadiah and Saleh Hodin, Nur Atikah (2024) 1H NMR-metabolomics studies on acute toxicity effect of lead in adult zebrafish (Danio rerio) model. Drug and Chemical Toxicology, 47 (5). pp. 573-586. ISSN 0148-0545; eISSN: 1525-6014 https://www.tandfonline.com/doi/full/10.1080/01480545.2024.2346751 10.1080/01480545.2024.2346751 |
| spellingShingle | Chong, Siok Geok Ismail, Intan Safinar Chong, Chou Min Mad Nasir, Nadiah Saleh Hodin, Nur Atikah 1H NMR-metabolomics studies on acute toxicity effect of lead in adult zebrafish (Danio rerio) model |
| title | 1H NMR-metabolomics studies on acute toxicity effect of lead in adult zebrafish (Danio rerio) model |
| title_full | 1H NMR-metabolomics studies on acute toxicity effect of lead in adult zebrafish (Danio rerio) model |
| title_fullStr | 1H NMR-metabolomics studies on acute toxicity effect of lead in adult zebrafish (Danio rerio) model |
| title_full_unstemmed | 1H NMR-metabolomics studies on acute toxicity effect of lead in adult zebrafish (Danio rerio) model |
| title_short | 1H NMR-metabolomics studies on acute toxicity effect of lead in adult zebrafish (Danio rerio) model |
| title_sort | 1h nmr-metabolomics studies on acute toxicity effect of lead in adult zebrafish (danio rerio) model |
| url | http://psasir.upm.edu.my/id/eprint/118255/ http://psasir.upm.edu.my/id/eprint/118255/ http://psasir.upm.edu.my/id/eprint/118255/ |