The role of TGFβ in human cancers
Transforming growth factor β (TGFβ) is secreted as a large latent precursor from both normal and transformed cells which needs to be activated for biological activity. The active TGFβ binds either directly to TβR-II or indirectly by binding to β-glycan which then presents the TGFβ to TβR-II. Formati...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2001
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| Online Access: | http://psasir.upm.edu.my/id/eprint/112551/ http://psasir.upm.edu.my/id/eprint/112551/3/112551.pdf |
| _version_ | 1848865973644296192 |
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| author | Wong, Shew-Fung Lai, Leslie C. |
| author_facet | Wong, Shew-Fung Lai, Leslie C. |
| author_sort | Wong, Shew-Fung |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Transforming growth factor β (TGFβ) is secreted as a large latent precursor from both normal and transformed cells which needs to be activated for biological activity. The active TGFβ binds either directly to TβR-II or indirectly by binding to β-glycan which then presents the TGFβ to TβR-II. Formation of the TGFβ-TβR-II complex rapidly leads to phosphorylation of TβR-I. TβR-I, in turn, phosphorylates receptor-specific Smads and induces their translocation into the nucleus. TGFβ is able to act as a growth stimulator or inhibitor and elicits a broad spectrum of biological, effects on various cell types. However, these cells may lose their sensitivity and responsiveness to TGFβ. Down-regulation or loss of functional receptors, aberrant signal transduction pathways due to Smad mutations, loss of the cell's ability to activate latent TGFβ, loss of the peptide itself or functional genes that control the transcription and translation of TGFβ may contribute to development of cancer. |
| first_indexed | 2025-11-15T14:13:13Z |
| format | Article |
| id | upm-112551 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T14:13:13Z |
| publishDate | 2001 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1125512025-03-06T04:10:43Z http://psasir.upm.edu.my/id/eprint/112551/ The role of TGFβ in human cancers Wong, Shew-Fung Lai, Leslie C. Transforming growth factor β (TGFβ) is secreted as a large latent precursor from both normal and transformed cells which needs to be activated for biological activity. The active TGFβ binds either directly to TβR-II or indirectly by binding to β-glycan which then presents the TGFβ to TβR-II. Formation of the TGFβ-TβR-II complex rapidly leads to phosphorylation of TβR-I. TβR-I, in turn, phosphorylates receptor-specific Smads and induces their translocation into the nucleus. TGFβ is able to act as a growth stimulator or inhibitor and elicits a broad spectrum of biological, effects on various cell types. However, these cells may lose their sensitivity and responsiveness to TGFβ. Down-regulation or loss of functional receptors, aberrant signal transduction pathways due to Smad mutations, loss of the cell's ability to activate latent TGFβ, loss of the peptide itself or functional genes that control the transcription and translation of TGFβ may contribute to development of cancer. Elsevier 2001 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/112551/3/112551.pdf Wong, Shew-Fung and Lai, Leslie C. (2001) The role of TGFβ in human cancers. Pathology, 33 (1). pp. 85-92. ISSN 0031-3025; eISSN: 1465-3931 https://www.sciencedirect.com/science/article/pii/S0031302516346414 10.1080/pat.33.1.85.92 |
| spellingShingle | Wong, Shew-Fung Lai, Leslie C. The role of TGFβ in human cancers |
| title | The role of TGFβ in human cancers |
| title_full | The role of TGFβ in human cancers |
| title_fullStr | The role of TGFβ in human cancers |
| title_full_unstemmed | The role of TGFβ in human cancers |
| title_short | The role of TGFβ in human cancers |
| title_sort | role of tgfβ in human cancers |
| url | http://psasir.upm.edu.my/id/eprint/112551/ http://psasir.upm.edu.my/id/eprint/112551/ http://psasir.upm.edu.my/id/eprint/112551/ http://psasir.upm.edu.my/id/eprint/112551/3/112551.pdf |