Potential utilization of phenolic acid compounds as anti-inflammatory agents through TNF-α Convertase inhibition mechanisms: a network pharmacology, docking, and molecular dynamics approach
Inflammation is a dysregulated immune response characterized by an excessive release of proinflammatory mediators, such as cytokines and prostanoids, leading to tissue damage and various pathological conditions. Natural compounds, notably phenolic acid phytocompounds from plants, have recently garne...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
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American Chemical Society
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| Online Access: | http://psasir.upm.edu.my/id/eprint/110490/ |
| _version_ | 1848865529736986624 |
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| author | Ekowati, Juni Tejo, Bimo A. Maulana, Saipul Kusuma, Wisnu Ananta Fatriani, Rizka Ramadhanti, Nabila Sekar Norhayati Novianty, Kholis Amalia Sulistyowaty, Melanny Ika Zubair, Muhammad Sulaiman Yamauchi, Takayasu Hamid, Iwan Sahrial |
| author_facet | Ekowati, Juni Tejo, Bimo A. Maulana, Saipul Kusuma, Wisnu Ananta Fatriani, Rizka Ramadhanti, Nabila Sekar Norhayati Novianty, Kholis Amalia Sulistyowaty, Melanny Ika Zubair, Muhammad Sulaiman Yamauchi, Takayasu Hamid, Iwan Sahrial |
| author_sort | Ekowati, Juni |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Inflammation is a dysregulated immune response characterized by an excessive release of proinflammatory mediators, such as cytokines and prostanoids, leading to tissue damage and various pathological conditions. Natural compounds, notably phenolic acid phytocompounds from plants, have recently garnered substantial interest as potential therapeutic agents to bolster well-being and combat inflammation recently. Based on previous research, the precise molecular mechanism underlying the anti-inflammatory activity of phenolic acids remains elusive. Therefore, this study aimed to predict the molecular mechanisms underpinning the anti-inflammatory properties of selected phenolic acid phytocompounds through comprehensive network pharmacology, molecular docking, and dynamic simulations. Network pharmacology analysis successfully identified TNF-α convertase as a potential target for anti-inflammatory purposes. Among tested compounds, chlorogenic acid (−6.90 kcal/mol), rosmarinic acid (−6.82 kcal/mol), and ellagic acid (−5.46 kcal/mol) exhibited the strongest binding affinity toward TNF-α convertase. Furthermore, phenolic acid compounds demonstrated molecular binding poses similar to those of the native ligand, indicating their potential as inhibitors of TNF-α convertase. This study provides valuable insights into the molecular mechanisms that drive the anti-inflammatory effects of phenolic compounds, particularly through the suppression of TNF-α production via TNF-α convertase inhibition, thus reinforcing their anti-inflammatory attributes. |
| first_indexed | 2025-11-15T14:06:10Z |
| format | Article |
| id | upm-110490 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T14:06:10Z |
| publisher | American Chemical Society |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1104902025-01-24T07:19:40Z http://psasir.upm.edu.my/id/eprint/110490/ Potential utilization of phenolic acid compounds as anti-inflammatory agents through TNF-α Convertase inhibition mechanisms: a network pharmacology, docking, and molecular dynamics approach Ekowati, Juni Tejo, Bimo A. Maulana, Saipul Kusuma, Wisnu Ananta Fatriani, Rizka Ramadhanti, Nabila Sekar Norhayati Novianty, Kholis Amalia Sulistyowaty, Melanny Ika Zubair, Muhammad Sulaiman Yamauchi, Takayasu Hamid, Iwan Sahrial Inflammation is a dysregulated immune response characterized by an excessive release of proinflammatory mediators, such as cytokines and prostanoids, leading to tissue damage and various pathological conditions. Natural compounds, notably phenolic acid phytocompounds from plants, have recently garnered substantial interest as potential therapeutic agents to bolster well-being and combat inflammation recently. Based on previous research, the precise molecular mechanism underlying the anti-inflammatory activity of phenolic acids remains elusive. Therefore, this study aimed to predict the molecular mechanisms underpinning the anti-inflammatory properties of selected phenolic acid phytocompounds through comprehensive network pharmacology, molecular docking, and dynamic simulations. Network pharmacology analysis successfully identified TNF-α convertase as a potential target for anti-inflammatory purposes. Among tested compounds, chlorogenic acid (−6.90 kcal/mol), rosmarinic acid (−6.82 kcal/mol), and ellagic acid (−5.46 kcal/mol) exhibited the strongest binding affinity toward TNF-α convertase. Furthermore, phenolic acid compounds demonstrated molecular binding poses similar to those of the native ligand, indicating their potential as inhibitors of TNF-α convertase. This study provides valuable insights into the molecular mechanisms that drive the anti-inflammatory effects of phenolic compounds, particularly through the suppression of TNF-α production via TNF-α convertase inhibition, thus reinforcing their anti-inflammatory attributes. American Chemical Society Article PeerReviewed Ekowati, Juni and Tejo, Bimo A. and Maulana, Saipul and Kusuma, Wisnu Ananta and Fatriani, Rizka and Ramadhanti, Nabila Sekar and Norhayati and Novianty, Kholis Amalia and Sulistyowaty, Melanny Ika and Zubair, Muhammad Sulaiman and Yamauchi, Takayasu and Hamid, Iwan Sahrial Potential utilization of phenolic acid compounds as anti-inflammatory agents through TNF-α Convertase inhibition mechanisms: a network pharmacology, docking, and molecular dynamics approach. ACS Omega. pp. 1-4. ISSN 2470-1343; eISSN: 2470-1343 https://pubs.acs.org/doi/suppl/10.1021/acsomega.3c06450/suppl_file/ao3c06450_si_001.pdf 10.1021/acsomega.3c06450.s001 |
| spellingShingle | Ekowati, Juni Tejo, Bimo A. Maulana, Saipul Kusuma, Wisnu Ananta Fatriani, Rizka Ramadhanti, Nabila Sekar Norhayati Novianty, Kholis Amalia Sulistyowaty, Melanny Ika Zubair, Muhammad Sulaiman Yamauchi, Takayasu Hamid, Iwan Sahrial Potential utilization of phenolic acid compounds as anti-inflammatory agents through TNF-α Convertase inhibition mechanisms: a network pharmacology, docking, and molecular dynamics approach |
| title | Potential utilization of phenolic acid compounds as anti-inflammatory agents through TNF-α Convertase inhibition mechanisms: a network pharmacology, docking, and molecular dynamics approach |
| title_full | Potential utilization of phenolic acid compounds as anti-inflammatory agents through TNF-α Convertase inhibition mechanisms: a network pharmacology, docking, and molecular dynamics approach |
| title_fullStr | Potential utilization of phenolic acid compounds as anti-inflammatory agents through TNF-α Convertase inhibition mechanisms: a network pharmacology, docking, and molecular dynamics approach |
| title_full_unstemmed | Potential utilization of phenolic acid compounds as anti-inflammatory agents through TNF-α Convertase inhibition mechanisms: a network pharmacology, docking, and molecular dynamics approach |
| title_short | Potential utilization of phenolic acid compounds as anti-inflammatory agents through TNF-α Convertase inhibition mechanisms: a network pharmacology, docking, and molecular dynamics approach |
| title_sort | potential utilization of phenolic acid compounds as anti-inflammatory agents through tnf-α convertase inhibition mechanisms: a network pharmacology, docking, and molecular dynamics approach |
| url | http://psasir.upm.edu.my/id/eprint/110490/ http://psasir.upm.edu.my/id/eprint/110490/ http://psasir.upm.edu.my/id/eprint/110490/ |