Mitochondrial dysfunction in Down Syndrome: from pathology to therapy
Mitochondrial dysfunctions have been described in Down syndrome (DS) caused by either partial or full trisomy of chromosome 21 (HSA21). Mitochondria play a crucial role in various vital functions in eukaryotic cells, especially in energy production, calcium homeostasis and programmed cell death. The...
| Main Authors: | Tan, Kai-Leng, Lee, Han-Chung, Cheah, Pike-See, Ling, King-Hwa |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/109511/ http://psasir.upm.edu.my/id/eprint/109511/1/1-s2.0-S0306452222006030-main.pdf |
Similar Items
Mitochondria dysfunction and bipolar disorder: from pathology to therapy
by: Lam, Xin-Jieh, et al.
Published: (2023)
by: Lam, Xin-Jieh, et al.
Published: (2023)
Potential role of JAK-STAT signaling pathway in the neurogenic-to-gliogenic shift in down syndrome brain
by: Lee, Han Chung, et al.
Published: (2016)
by: Lee, Han Chung, et al.
Published: (2016)
MicroRNAs and intellectual disability (ID) in Down syndrome, X-linked ID and Fragile X syndrome
by: Siew, Wei Hong, et al.
Published: (2013)
by: Siew, Wei Hong, et al.
Published: (2013)
Chromosomal and cellular therapeutic approaches for Down syndrome: a research update
by: Huang, Tan, et al.
Published: (2024)
by: Huang, Tan, et al.
Published: (2024)
The role of JAK-STAT signalling in the developing brain of Ts1Cje mouse model for Down syndrome
by: Lee, Han Chung, et al.
Published: (2015)
by: Lee, Han Chung, et al.
Published: (2015)
The restoration of REST inhibits reactivity of Down syndrome iPSC-derived astrocytes
by: Huang, Tan, et al.
Published: (2025)
by: Huang, Tan, et al.
Published: (2025)
Dysregulation of REST and its target genes impacts the fate of neural progenitor cells in down syndrome
by: Tan, Huang, et al.
Published: (2025)
by: Tan, Huang, et al.
Published: (2025)
Disrupted interferon-related molecular networks and the over-expressed Ifnar1 in the brain of adult Ts1Cje mouse model of Down syndrome
by: Tan, Kai Leng, et al.
Published: (2016)
by: Tan, Kai Leng, et al.
Published: (2016)
Overexpression of interferon alpha or beta receptors in the brain of adult Ts1Cje mouse model of Down syndrome
by: Tan, Kai Leng, et al.
Published: (2015)
by: Tan, Kai Leng, et al.
Published: (2015)
Expression profiling of genes involved in the development and function of skeletal muscles in Ts1Cje mouse model of down syndrome
by: Cheah, Pike See, et al.
Published: (2018)
by: Cheah, Pike See, et al.
Published: (2018)
REST targets JAK–STAT and HIF-1 signaling pathways in human Down syndrome brain and neural cells
by: Huang, Tan, et al.
Published: (2023)
by: Huang, Tan, et al.
Published: (2023)
The expression profile of miR-3099 during neural development of Ts1Cje mouse model of down syndrome
by: Zainal Abidin, Shahidee, et al.
Published: (2021)
by: Zainal Abidin, Shahidee, et al.
Published: (2021)
Lithium restores nuclear REST and Mitigates oxidative stress in down syndrome iPSC-Derived neurons
by: Lam, Xin-Jieh, et al.
Published: (2025)
by: Lam, Xin-Jieh, et al.
Published: (2025)
Brain insulin resistance in down syndrome: involvement of PI3K-AKT/MTOR axis in early-onset of Alzheimer's disease and its potential as a therapeutic target
by: Azimzadeh, Mansour, et al.
Published: (2024)
by: Azimzadeh, Mansour, et al.
Published: (2024)
Understanding perspectives and research trends in down syndrome neuropathogenesis: a bibliometric analysis
by: Huang, Tan, et al.
Published: (2024)
by: Huang, Tan, et al.
Published: (2024)
Ts1Cje mouse model for Down syndrome research
by: Ling, King Hwa
Published: (2015)
by: Ling, King Hwa
Published: (2015)
Transcriptional profiling of the postnatal brain of the Ts1Cje mouse model of Down syndrome
by: Tan, Kai Leng, et al.
Published: (2014)
by: Tan, Kai Leng, et al.
Published: (2014)
Ts1Cje mouse model for Down syndrome exhibits motor function deficit; the potential role of MRFS and peripheral nervous system
by: Bala, Usman, et al.
Published: (2015)
by: Bala, Usman, et al.
Published: (2015)
Targeted differential gene expression profiling of skeletal muscles isolated from Ts1Cje mouse model for Down syndrome
by: Leong, Melody Pui Yee, et al.
Published: (2015)
by: Leong, Melody Pui Yee, et al.
Published: (2015)
Down syndrome and cell therapy : a review
by: Norizam Salamt,, et al.
Published: (2021)
by: Norizam Salamt,, et al.
Published: (2021)
Functional transcriptome analysis of the postnatal brain of the Ts1Cje mouse model for Down syndrome reveals global disruption of interferon-related molecular networks
by: Ling, King Hwa, et al.
Published: (2014)
by: Ling, King Hwa, et al.
Published: (2014)
Expression profiling of notch signalling pathway and gamma-secretase activity in the brain of Ts1Cje mouse model of down syndrome
by: Md Yusof, Hadri Hadi, et al.
Published: (2019)
by: Md Yusof, Hadri Hadi, et al.
Published: (2019)
Perturbed metabolic profiles associated with muscle weakness seen in adult Ts1Cje mouse model of Down syndrome
by: Lim, Chai Ling, et al.
Published: (2019)
by: Lim, Chai Ling, et al.
Published: (2019)
Reduced REST expression in neural progenitor cells, adult cortex, and impaired REST nuclear translocation in the prefrontal cortex of Ts1Cje mouse model of Down Syndrome
by: Chong, Teik Lim, et al.
Published: (2024)
by: Chong, Teik Lim, et al.
Published: (2024)
Gene and protein expression profiles of JAK-STAT signalling pathway in the developing brain of the Ts1Cje down syndrome mouse model
by: Lee, Han Chung, et al.
Published: (2019)
by: Lee, Han Chung, et al.
Published: (2019)
Identification of disrupted molecular networks involved in brain maturation and function in the TS1CJE mouse model of down syndrome
by: Tan, Kai Leng
Published: (2016)
by: Tan, Kai Leng
Published: (2016)
Harvesting the maximum length of sciatic nerve from adult mice: a step-by-step approach
by: Bala, Usman, et al.
Published: (2014)
by: Bala, Usman, et al.
Published: (2014)
Defects in nerve conduction velocity and different muscle fibre-type specificity contribute to muscle weakness in Ts1Cje Down syndrome mouse model
by: Bala, Usman, et al.
Published: (2018)
by: Bala, Usman, et al.
Published: (2018)
Down syndrome face recognition: a review
by: Agbolade, Olalekan, et al.
Published: (2020)
by: Agbolade, Olalekan, et al.
Published: (2020)
Prenatal screening of down syndrome.
by: Rosli, Rozita, et al.
Published: (2006)
by: Rosli, Rozita, et al.
Published: (2006)
Erectile dysfunction and methadone maintenance therapy
by: Fitri Fareez R,, et al.
Published: (2020)
by: Fitri Fareez R,, et al.
Published: (2020)
Knowledge on Down Syndrome and Down Syndrome prenatal screening tests among pregnant women in Kuantan, Pahang
by: Abdul Ghafar, Nurul Fatehah, et al.
Published: (2019)
by: Abdul Ghafar, Nurul Fatehah, et al.
Published: (2019)
Urine tests for Down's syndrome screening
by: Alldred, S. Kate, et al.
Published: (2015)
by: Alldred, S. Kate, et al.
Published: (2015)
The sibling experience: Living with Down syndrome or Rett syndrome in the family
by: Glasson, E., et al.
Published: (2016)
by: Glasson, E., et al.
Published: (2016)
Single nucleotide polymorphism of BDNF Val66Met (rs6265) and its association to neuropsychiatric disorders
by: Asraa Faris, et al.
Published: (2020)
by: Asraa Faris, et al.
Published: (2020)
Sexual dysfunction in patients with polycystic ovary syndrome in Malaysia
by: Dashti, Sareh, et al.
Published: (2016)
by: Dashti, Sareh, et al.
Published: (2016)
Gene network disruptions and neurogenesis defects in the adult Ts1Cje mouse model of Down syndrome
by: Hewitt, Chelsee Ann, et al.
Published: (2010)
by: Hewitt, Chelsee Ann, et al.
Published: (2010)
Factors associated with parenting stress among mothers with down syndrome children in Kota Bharu, Kelantan
by: Ling, Lee Wai
Published: (2014)
by: Ling, Lee Wai
Published: (2014)
Towards Understanding the Role of Trisomy 21 in Down Syndrome Leukaemia
by: Carey-Smith, Shannon Lee
Published: (2024)
by: Carey-Smith, Shannon Lee
Published: (2024)
Quality of life domains for children with Down syndrome
by: Murphy, N., et al.
Published: (2016)
by: Murphy, N., et al.
Published: (2016)
Similar Items
-
Mitochondria dysfunction and bipolar disorder: from pathology to therapy
by: Lam, Xin-Jieh, et al.
Published: (2023) -
Potential role of JAK-STAT signaling pathway in the neurogenic-to-gliogenic shift in down syndrome brain
by: Lee, Han Chung, et al.
Published: (2016) -
MicroRNAs and intellectual disability (ID) in Down syndrome, X-linked ID and Fragile X syndrome
by: Siew, Wei Hong, et al.
Published: (2013) -
Chromosomal and cellular therapeutic approaches for Down syndrome: a research update
by: Huang, Tan, et al.
Published: (2024) -
The role of JAK-STAT signalling in the developing brain of Ts1Cje mouse model for Down syndrome
by: Lee, Han Chung, et al.
Published: (2015)