Discovery of ruthenium(ii) metallocompound and olaparib synergy for cancer combination therapy

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Discovery of ruthenium(ii) metallocompound and olaparib synergy for cancer combination therapy

Synergistic drug combinations can extend the use of poly(ADP-ribose) polymerase inhibitors (PARPi) such as Olaparib to BRCA-proficient tumors and overcome acquired or de novo drug resistance. To identify new synergistic combinations for PARPi, we screened a “micro-library” comprising a mix of commer...

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Bibliographic Details
Main Authors:	Yusoh, Nur Aininie, Tiley, Paul R., James, Steffan D., Harun, Siti Norain, Thomas, Jim A., Saad, Norazalina, Ling, Wei Hii, Suet, Lin Chia, Gill, Martin R., Ahmad, Haslina
Format:	Article
Language:	English
Published:	American Chemical Society 2023
Online Access:	http://psasir.upm.edu.my/id/eprint/107358/ http://psasir.upm.edu.my/id/eprint/107358/1/107358.pdf

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