Discovery of ruthenium(ii) metallocompound and olaparib synergy for cancer combination therapy

Discovery of ruthenium(ii) metallocompound and olaparib synergy for cancer combination therapy

Synergistic drug combinations can extend the use of poly(ADP-ribose) polymerase inhibitors (PARPi) such as Olaparib to BRCA-proficient tumors and overcome acquired or de novo drug resistance. To identify new synergistic combinations for PARPi, we screened a “micro-library” comprising a mix of commer...

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Bibliographic Details
Main Authors: Yusoh, Nur Aininie, Tiley, Paul R., James, Steffan D., Harun, Siti Norain, Thomas, Jim A., Saad, Norazalina, Ling, Wei Hii, Suet, Lin Chia, Gill, Martin R., Ahmad, Haslina
Format: Article
Language:English
Published: American Chemical Society 2023
Online Access:http://psasir.upm.edu.my/id/eprint/107358/
http://psasir.upm.edu.my/id/eprint/107358/1/107358.pdf

Internet

http://psasir.upm.edu.my/id/eprint/107358/
http://psasir.upm.edu.my/id/eprint/107358/1/107358.pdf

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