Role of the IL8 rs4073 polymorphism in central nervous system toxicity in patients receiving multidrug-resistant tuberculosis treatment
Objective: To determine the role of the IL8 rs4073 polymorphism in predicting the risk of central nervous system (CNS) toxicity in patients receiving standard pharmacological treatment for multidrug-resistant tuberculosis (MDR-TB). Methods: A cohort of 85 consenting MDR-TB patients receiving treatme...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
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Sociedade Brasileira de Pneumologia e Tisiologia
2024
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| Online Access: | http://psasir.upm.edu.my/id/eprint/106237/ |
| _version_ | 1848864723622166528 |
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| author | Mohammed Badamasi, Ibrahim Muhammad, Muktar Umar, Aishat Ahmad Madugu, Umm-Ayman Misbahu Gadanya, Muktar Ahmed Aliyu, Isa Abubakar Kabir, Imam Malik Umar, Ibrahim Aliyu Johnson, Ochigbo Stanslas, Johnson |
| author_facet | Mohammed Badamasi, Ibrahim Muhammad, Muktar Umar, Aishat Ahmad Madugu, Umm-Ayman Misbahu Gadanya, Muktar Ahmed Aliyu, Isa Abubakar Kabir, Imam Malik Umar, Ibrahim Aliyu Johnson, Ochigbo Stanslas, Johnson |
| author_sort | Mohammed Badamasi, Ibrahim |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Objective: To determine the role of the IL8 rs4073 polymorphism in predicting the risk of central nervous system (CNS) toxicity in patients receiving standard pharmacological treatment for multidrug-resistant tuberculosis (MDR-TB). Methods: A cohort of 85 consenting MDR-TB patients receiving treatment with second-line antituberculosis drugs had their blood samples amplified for the IL8 (rs4073) gene and genotyped. All patients were clinically screened for evidence of treatment toxicity and categorized accordingly. Crude and adjusted associations were assessed. Results: The chief complaints fell into the following categories: CNS toxicity; gastrointestinal toxicity; skin toxicity; and eye and ear toxicities. Symptoms of gastrointestinal toxicity were reported by 59 of the patients, and symptoms of CNS toxicity were reported by 42.7. With regard to the genotypes of IL8 (rs4073), the following were identified: AA, in 64 of the study participants; AT, in 7; and TT, in 11. A significant association was found between the dominant model of inheritance and CNS toxicity for the crude model (p = 0.024; OR = 3.57; 95 CI, 1.18-10.76) and the adjusted model (p = 0.031; OR = 3.92; 95 CI, 1.13-13.58). The AT+TT genotype of IL8 (rs4073) showed a 3.92 times increased risk of CNS toxicity when compared with the AA genotype. Conclusions: The AT+TT genotype has a tendency to be associated with an increased risk of adverse clinical features during MDR-TB treatment. |
| first_indexed | 2025-11-15T13:53:21Z |
| format | Article |
| id | upm-106237 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T13:53:21Z |
| publishDate | 2024 |
| publisher | Sociedade Brasileira de Pneumologia e Tisiologia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1062372024-05-08T13:59:57Z http://psasir.upm.edu.my/id/eprint/106237/ Role of the IL8 rs4073 polymorphism in central nervous system toxicity in patients receiving multidrug-resistant tuberculosis treatment Mohammed Badamasi, Ibrahim Muhammad, Muktar Umar, Aishat Ahmad Madugu, Umm-Ayman Misbahu Gadanya, Muktar Ahmed Aliyu, Isa Abubakar Kabir, Imam Malik Umar, Ibrahim Aliyu Johnson, Ochigbo Stanslas, Johnson Objective: To determine the role of the IL8 rs4073 polymorphism in predicting the risk of central nervous system (CNS) toxicity in patients receiving standard pharmacological treatment for multidrug-resistant tuberculosis (MDR-TB). Methods: A cohort of 85 consenting MDR-TB patients receiving treatment with second-line antituberculosis drugs had their blood samples amplified for the IL8 (rs4073) gene and genotyped. All patients were clinically screened for evidence of treatment toxicity and categorized accordingly. Crude and adjusted associations were assessed. Results: The chief complaints fell into the following categories: CNS toxicity; gastrointestinal toxicity; skin toxicity; and eye and ear toxicities. Symptoms of gastrointestinal toxicity were reported by 59 of the patients, and symptoms of CNS toxicity were reported by 42.7. With regard to the genotypes of IL8 (rs4073), the following were identified: AA, in 64 of the study participants; AT, in 7; and TT, in 11. A significant association was found between the dominant model of inheritance and CNS toxicity for the crude model (p = 0.024; OR = 3.57; 95 CI, 1.18-10.76) and the adjusted model (p = 0.031; OR = 3.92; 95 CI, 1.13-13.58). The AT+TT genotype of IL8 (rs4073) showed a 3.92 times increased risk of CNS toxicity when compared with the AA genotype. Conclusions: The AT+TT genotype has a tendency to be associated with an increased risk of adverse clinical features during MDR-TB treatment. Sociedade Brasileira de Pneumologia e Tisiologia 2024 Article PeerReviewed Mohammed Badamasi, Ibrahim and Muhammad, Muktar and Umar, Aishat Ahmad and Madugu, Umm-Ayman Misbahu and Gadanya, Muktar Ahmed and Aliyu, Isa Abubakar and Kabir, Imam Malik and Umar, Ibrahim Aliyu and Johnson, Ochigbo and Stanslas, Johnson (2024) Role of the IL8 rs4073 polymorphism in central nervous system toxicity in patients receiving multidrug-resistant tuberculosis treatment. Jornal Brasileiro de Pneumologia, 50 (1). pp. 1-6. ISSN 1806-3713; ESSN: 1806-3756 https://www.jornaldepneumologia.com.br/details/3912/en-US/role-of-the-il8-rs4073-polymorphism-in-central-nervous-system-toxicity-in-patients-receiving-multidrug-resistant-tuberculosis-treatment 10.36416/1806-3756/e20230338 |
| spellingShingle | Mohammed Badamasi, Ibrahim Muhammad, Muktar Umar, Aishat Ahmad Madugu, Umm-Ayman Misbahu Gadanya, Muktar Ahmed Aliyu, Isa Abubakar Kabir, Imam Malik Umar, Ibrahim Aliyu Johnson, Ochigbo Stanslas, Johnson Role of the IL8 rs4073 polymorphism in central nervous system toxicity in patients receiving multidrug-resistant tuberculosis treatment |
| title | Role of the IL8 rs4073 polymorphism in central nervous system toxicity in patients receiving multidrug-resistant tuberculosis treatment |
| title_full | Role of the IL8 rs4073 polymorphism in central nervous system toxicity in patients receiving multidrug-resistant tuberculosis treatment |
| title_fullStr | Role of the IL8 rs4073 polymorphism in central nervous system toxicity in patients receiving multidrug-resistant tuberculosis treatment |
| title_full_unstemmed | Role of the IL8 rs4073 polymorphism in central nervous system toxicity in patients receiving multidrug-resistant tuberculosis treatment |
| title_short | Role of the IL8 rs4073 polymorphism in central nervous system toxicity in patients receiving multidrug-resistant tuberculosis treatment |
| title_sort | role of the il8 rs4073 polymorphism in central nervous system toxicity in patients receiving multidrug-resistant tuberculosis treatment |
| url | http://psasir.upm.edu.my/id/eprint/106237/ http://psasir.upm.edu.my/id/eprint/106237/ http://psasir.upm.edu.my/id/eprint/106237/ |