Substituted benzo[i]phenanthridines as mammalian topoisomerase-Targeting agents

QR Code

Substituted benzo[i]phenanthridines as mammalian topoisomerase-Targeting agents

Several benzo[c]phenanthridine and protoberberine alkaloids, such as nitidine and berberrubine, are known to induce DNA cleavage in the presence of either topoisomerase I or II. Structure–activity studies performed on various analogues related to benzo[c]phenanthridine and protoberberine alkaloids h...

Full description

Bibliographic Details
Main Authors:	Makhey, D., Li, D., Zhao, B., Sim, S.P, Li, TK, Liu, A., Liu, L.F., LaVoie, E.J.
Format:	Article
Language:	English
Published:	Elsevier Ltd 2003
Subjects:	QD Chemistry R Medicine (General)
Online Access:	http://ir.unimas.my/id/eprint/2485/ http://ir.unimas.my/id/eprint/2485/1/Substituted%20benzo%5Bi%5Dphenanthridines%20as%20mammalian%20topoisomerase-Targeting%20agents.pdf

Similar Items

8,9-Methylenedioxybenzo[i]phenanthridines_ Topoisomerase I-Targeting activity and cytotoxicity
by: Li, D., et al.
Published: (2003)

2,3-Dimethoxybenzo[i]phenanthridines_ topoisomerase I-targeting anticancer agents
by: Lia, D., et al.
Published: (2002)

2″-Substituted 5-phenylterbenzimidazoles as topoisomerase I poisons
by: Rangarajan, M., et al.
Published: (2000)

Heterocyclic bibenzimidazole derivatives as topoisomerase I inhibitors
by: Jin, S., et al.
Published: (2000)

Topoisomerase I inhibition and cytotoxicity of 5-Bromo- and 5-Phenylterbenzimidazoles
by: Rangarajan, M., et al.
Published: (2000)

Site-Specific Topoisomerase I-Mediated DNA Cleavage Induced by Nogalamycin: A Potential Role of Ligand-Induced DNA Bending at a Distal Site
by: Sim, S.P, et al.
Published: (2000)

Familial cortical dysplasia caused by mutation in the mammalian target of rapamycin regulator NPRL3
by: Sim, J., et al.
Published: (2016)

Peroxidative injury of rats intratracheally instilled with benzo(a)pyrene and benzo(e)pyrene
by: Karim, Abdulkarim Jafar, et al.
Published: (2009)

Nucleolytic Cleavage of the Mixed Lineage Leukemia Breakpoint Cluster Region during Apoptosis
by: Sim, S.P, et al.
Published: (2001)

Determination of fluoranthene, benzo[b]fluoranthene and benzo[a]pyrene in meat and fish products and their intake by Malaysian
by: Jahurul, Md. Haque Akanda, et al.
Published: (2013)

Determination of fluoranthene, benzo[b]fluoranthene and benzo[a]pyrene in meat and fish products and their intake by Malaysian
by: Jahurul, Md. Haque Akanda, et al.
Published: (2013)

Human topoisomerase II alpha as a prognostic biomarker in cancer chemotherapy
by: Ali, Yousaf, et al.
Published: (2016)

Expression Of Recombinant Human Dna Topoisomerase In Pichia Pastoris And Analysis Of Its Activity
by: Chan, Mooi Kwai
Published: (2017)

Studies On The Effect Of Benzo(a)Pyrene In Rats
by: Thoria, Ali Abdul Hameed Dragh
Published: (2001)

Induction of immunosuppression by benzo (a) pyrene in broilers
by: Saulol Hamid, Nur Fazila, et al.
Published: (2010)

The role of microRNAs in the pre-implantation mammalian embryo
by: Makri, K.D.
Published: (2021)

Effects of marinating on the formation of polycyclic aromatic hydrocarbons (benzo[a]pyrene, benzo[b]fluoranthene and fluoranthene) in grilled beef meat
by: Afsaneh, Farhadian, et al.
Published: (2012)

Toxicity studies using mammalian cells and impedance spectroscopy method
by: Xudong, Zhang, et al.
Published: (2015)

siRNA blocking of mammalian target of rapamycin (mTOR) attenuates pathology in annonacin-induced tauopathy in mice
by: Salama, Mohamed M., et al.
Published: (2019)

Chitosan microcarriers in mammalian cell culture
by: Hussein, Abeir, et al.
Published: (2014)

Culturing and maintaining mammalian cell culture
by: Ahmad Raus, Raha, et al.
Published: (2018)

Mechanism of Action of Camptothecin
by: Liu, L.F., et al.
Published: (2006)

The Effect of Benzo(A)Pyrene on Male Mouse Mus Musculus
by: Hanachi, Parichehr
Published: (2002)

Enrichment of benzo(a)pyrene in milk by saponification-solvent microextraction
by: Lim, Khai Wei, et al.
Published: (2024)

The effect of concentrations and properties of phenanthrene, pyrene, and benzo(a)pyrene on desorption in contaminated soil aged for 1 year
by: Li, Xin Yong, et al.
Published: (2013)

STRETCHABLE lab-on-chip device with impedance spectroscopy capability for mammalian cell studies
by: Xudong, Zhang, et al.
Published: (2016)

Mammalian chitotriosidase and its role in innate immunity
by: Hall, Andrew J.
Published: (2009)

Metabolomics investigations of the effect of drugs on mammalian cells
by: Ngamratanapaiboon, Surachai
Published: (2017)

Recognition of hepaciviruses by ficolins in different mammalian species
by: Adedeji, Yemisi Oluwatomi
Published: (2020)

Investigation into mammalian os cordis and cartilago cordis
by: Best, AS
Published: (2022)

Comparing the expression of human DNA topoisomerase I in KM71H and X33 strains of Pichia pastoris
by: Ruo, Ping Ang, et al.
Published: (2016)

Effects Of Camptothecin On Pichia Pastoris Strain Smd1168h Expressing Dna Topoisomerase I On Agar Plates
by: Devi Vadiveloo, Sajetra
Published: (2020)

Benzo(a)pyrene degradation and microbial community responses in composted soil
by: Zhu, Fengxiao, et al.
Published: (2017)

6-Cyanonaphthalen-2-yl 4-hexylbenzoate
by: Lutfor, M. R., et al.
Published: (2014)

The Effect of Benzo (A) Pyrene (BaP) On the Respiratory Tract of Dogs
by: Hamzah, Hazilawati
Published: (2000)

Pulmonary modulation of benzo[a]pyrene-induced hemato- and hepatotoxicity in broilers
by: Latif, I. K., et al.
Published: (2010)

Immunosuppressive effects of benzo (a) pyrene on Newcastle disease vaccination in broilers
by: Ahmad Zabidi, Norameza, et al.
Published: (2010)

A process for detecting benzo[a]pyrene in polluted aquatic environments
by: Varnamkhasti, Ali Karami, et al.
Published: (2011)

Reduced cytotoxicity of silver ions to mammalian cells at high concentration due to the formation of silver chloride
by: Zhang, S., et al.
Published: (2013)

The supercritical processing of mammalian cells for applications in tissue engineering
by: Ginty, Patric J.
Published: (2006)