Heterocyclic bibenzimidazole derivatives as topoisomerase I inhibitors

Heterocyclic bibenzimidazole derivatives as topoisomerase I inhibitors

A series of 2′-heterocyclic derivatives of 5-phenyl-2,5′-1H-bibenzimidazoles were evaluated for topoisomerase I poisoning activity and cytotoxicity. Topo I poisoning activity was associated with 2′-derivatives that possessed a hydrogen atom capable of hydrogen bond formation, suggesting that the int...

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Bibliographic Details
Main Authors: Jin, S., Kim, J.S., Sim, S.P, Liu, A., Pilch, D.S., Liu, L.F., LaVoie, E.J.
Format: Article
Language:English
Published: Bioorganic & Medicinal Chemistry Letters 2000
Subjects:
QD Chemistry
QK Botany
R Medicine (General)
Online Access:http://ir.unimas.my/id/eprint/2241/
http://ir.unimas.my/id/eprint/2241/1/Heterocyclic%20bibenzimidazole%20derivatives%20as%20topoisomerase%20I%20inhibitors.pdf

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