Heterocyclic bibenzimidazole derivatives as topoisomerase I inhibitors
A series of 2′-heterocyclic derivatives of 5-phenyl-2,5′-1H-bibenzimidazoles were evaluated for topoisomerase I poisoning activity and cytotoxicity. Topo I poisoning activity was associated with 2′-derivatives that possessed a hydrogen atom capable of hydrogen bond formation, suggesting that the int...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Bioorganic & Medicinal Chemistry Letters
2000
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| Subjects: | |
| Online Access: | http://ir.unimas.my/id/eprint/2241/ http://ir.unimas.my/id/eprint/2241/1/Heterocyclic%20bibenzimidazole%20derivatives%20as%20topoisomerase%20I%20inhibitors.pdf |