Heterocyclic bibenzimidazole derivatives as topoisomerase I inhibitors
A series of 2′-heterocyclic derivatives of 5-phenyl-2,5′-1H-bibenzimidazoles were evaluated for topoisomerase I poisoning activity and cytotoxicity. Topo I poisoning activity was associated with 2′-derivatives that possessed a hydrogen atom capable of hydrogen bond formation, suggesting that the int...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Bioorganic & Medicinal Chemistry Letters
2000
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| Subjects: | |
| Online Access: | http://ir.unimas.my/id/eprint/2241/ http://ir.unimas.my/id/eprint/2241/1/Heterocyclic%20bibenzimidazole%20derivatives%20as%20topoisomerase%20I%20inhibitors.pdf |
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| author | Jin, S. Kim, J.S. Sim, S.P Liu, A. Pilch, D.S. Liu, L.F. LaVoie, E.J. |
| author_facet | Jin, S. Kim, J.S. Sim, S.P Liu, A. Pilch, D.S. Liu, L.F. LaVoie, E.J. |
| author_sort | Jin, S. |
| building | UNIMAS Institutional Repository |
| collection | Online Access |
| description | A series of 2′-heterocyclic derivatives of 5-phenyl-2,5′-1H-bibenzimidazoles were evaluated for topoisomerase I poisoning activity and cytotoxicity. Topo I poisoning activity was associated with 2′-derivatives that possessed a hydrogen atom capable of hydrogen bond formation, suggesting that the interatomic distances between such hydrogen atoms and the heteroatoms on the adjacent benzimidazole influence activity. |
| first_indexed | 2025-11-15T05:59:57Z |
| format | Article |
| id | unimas-2241 |
| institution | Universiti Malaysia Sarawak |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T05:59:57Z |
| publishDate | 2000 |
| publisher | Bioorganic & Medicinal Chemistry Letters |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | unimas-22412015-03-20T07:55:26Z http://ir.unimas.my/id/eprint/2241/ Heterocyclic bibenzimidazole derivatives as topoisomerase I inhibitors Jin, S. Kim, J.S. Sim, S.P Liu, A. Pilch, D.S. Liu, L.F. LaVoie, E.J. QD Chemistry QK Botany R Medicine (General) A series of 2′-heterocyclic derivatives of 5-phenyl-2,5′-1H-bibenzimidazoles were evaluated for topoisomerase I poisoning activity and cytotoxicity. Topo I poisoning activity was associated with 2′-derivatives that possessed a hydrogen atom capable of hydrogen bond formation, suggesting that the interatomic distances between such hydrogen atoms and the heteroatoms on the adjacent benzimidazole influence activity. Bioorganic & Medicinal Chemistry Letters 2000 Article NonPeerReviewed text en http://ir.unimas.my/id/eprint/2241/1/Heterocyclic%20bibenzimidazole%20derivatives%20as%20topoisomerase%20I%20inhibitors.pdf Jin, S. and Kim, J.S. and Sim, S.P and Liu, A. and Pilch, D.S. and Liu, L.F. and LaVoie, E.J. (2000) Heterocyclic bibenzimidazole derivatives as topoisomerase I inhibitors. Bioorganic & Medicinal Chemistry Letters , 10 (8). pp. 719-723. |
| spellingShingle | QD Chemistry QK Botany R Medicine (General) Jin, S. Kim, J.S. Sim, S.P Liu, A. Pilch, D.S. Liu, L.F. LaVoie, E.J. Heterocyclic bibenzimidazole derivatives as topoisomerase I inhibitors |
| title | Heterocyclic bibenzimidazole derivatives as topoisomerase I inhibitors |
| title_full | Heterocyclic bibenzimidazole derivatives as topoisomerase I inhibitors |
| title_fullStr | Heterocyclic bibenzimidazole derivatives as topoisomerase I inhibitors |
| title_full_unstemmed | Heterocyclic bibenzimidazole derivatives as topoisomerase I inhibitors |
| title_short | Heterocyclic bibenzimidazole derivatives as topoisomerase I inhibitors |
| title_sort | heterocyclic bibenzimidazole derivatives as topoisomerase i inhibitors |
| topic | QD Chemistry QK Botany R Medicine (General) |
| url | http://ir.unimas.my/id/eprint/2241/ http://ir.unimas.my/id/eprint/2241/1/Heterocyclic%20bibenzimidazole%20derivatives%20as%20topoisomerase%20I%20inhibitors.pdf |