Double Carbonylation Using Glyoxal (HCOCOH): A Practical Copper-Promoted Synthesis of Isatins from Primary and Secondary Anilines
A novel double carbonylation process has been demonstrated with easily available HCOCOH (glyoxal) as the double carbonylation reagent. Simple CuCl2·2H2O (copper(II) chloride dihydrate) was used as the oxidant for this transformation. Under optimized reaction conditions, various primary and secondary...
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| Format: | Article |
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WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
2017
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| Online Access: | http://ir.unimas.my/id/eprint/17313/ |
| _version_ | 1848838262618062848 |
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| author | Hui, Suzie Chin Kuan Wei, Sun Lu, Wang Chungu, Xia Meng, Guan Tay Chao, Liu |
| author_facet | Hui, Suzie Chin Kuan Wei, Sun Lu, Wang Chungu, Xia Meng, Guan Tay Chao, Liu |
| author_sort | Hui, Suzie Chin Kuan |
| building | UNIMAS Institutional Repository |
| collection | Online Access |
| description | A novel double carbonylation process has been demonstrated with easily available HCOCOH (glyoxal) as the double carbonylation reagent. Simple CuCl2·2H2O (copper(II) chloride dihydrate) was used as the oxidant for this transformation. Under optimized reaction conditions, various primary and secondary anilines were double-carbonylated to afford their corresponding isatins (26 examples, up to 80% yields). |
| first_indexed | 2025-11-15T06:52:46Z |
| format | Article |
| id | unimas-17313 |
| institution | Universiti Malaysia Sarawak |
| institution_category | Local University |
| last_indexed | 2025-11-15T06:52:46Z |
| publishDate | 2017 |
| publisher | WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | unimas-173132017-08-21T04:58:18Z http://ir.unimas.my/id/eprint/17313/ Double Carbonylation Using Glyoxal (HCOCOH): A Practical Copper-Promoted Synthesis of Isatins from Primary and Secondary Anilines Hui, Suzie Chin Kuan Wei, Sun Lu, Wang Chungu, Xia Meng, Guan Tay Chao, Liu QD Chemistry A novel double carbonylation process has been demonstrated with easily available HCOCOH (glyoxal) as the double carbonylation reagent. Simple CuCl2·2H2O (copper(II) chloride dihydrate) was used as the oxidant for this transformation. Under optimized reaction conditions, various primary and secondary anilines were double-carbonylated to afford their corresponding isatins (26 examples, up to 80% yields). WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim 2017 Article PeerReviewed Hui, Suzie Chin Kuan and Wei, Sun and Lu, Wang and Chungu, Xia and Meng, Guan Tay and Chao, Liu (2017) Double Carbonylation Using Glyoxal (HCOCOH): A Practical Copper-Promoted Synthesis of Isatins from Primary and Secondary Anilines. Advanced Synthesis & Catalysis, 359 (16). ISSN 1615-4169 http://onlinelibrary.wiley.com/doi/10.1002/adsc.201700583/full 10.1002/adsc.201700583 |
| spellingShingle | QD Chemistry Hui, Suzie Chin Kuan Wei, Sun Lu, Wang Chungu, Xia Meng, Guan Tay Chao, Liu Double Carbonylation Using Glyoxal (HCOCOH): A Practical Copper-Promoted Synthesis of Isatins from Primary and Secondary Anilines |
| title | Double Carbonylation Using Glyoxal (HCOCOH): A Practical Copper-Promoted Synthesis of Isatins from Primary and Secondary Anilines |
| title_full | Double Carbonylation Using Glyoxal (HCOCOH): A Practical Copper-Promoted Synthesis of Isatins from Primary and Secondary Anilines |
| title_fullStr | Double Carbonylation Using Glyoxal (HCOCOH): A Practical Copper-Promoted Synthesis of Isatins from Primary and Secondary Anilines |
| title_full_unstemmed | Double Carbonylation Using Glyoxal (HCOCOH): A Practical Copper-Promoted Synthesis of Isatins from Primary and Secondary Anilines |
| title_short | Double Carbonylation Using Glyoxal (HCOCOH): A Practical Copper-Promoted Synthesis of Isatins from Primary and Secondary Anilines |
| title_sort | double carbonylation using glyoxal (hcocoh): a practical copper-promoted synthesis of isatins from primary and secondary anilines |
| topic | QD Chemistry |
| url | http://ir.unimas.my/id/eprint/17313/ http://ir.unimas.my/id/eprint/17313/ http://ir.unimas.my/id/eprint/17313/ |