Toxicity screening analysis of dipropyl phthalate, DPP on early vertebrate development
Phthalates are most frequently used chemical in industries to make plasticizers and polymer additive in gel capsules, cosmetic, and other personal care products. This study was initiated to enhance our insight on the health and environmental impact on Dipropyl phthalate, DPP - one of the phthalat...
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| Format: | Final Year Project Report / IMRAD |
| Language: | English |
| Published: |
Universiti Malaysia Sarawak, (UNIMAS)
2016
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| Subjects: | |
| Online Access: | http://ir.unimas.my/id/eprint/15471/ http://ir.unimas.my/id/eprint/15471/3/Nur%20Qistina%20Diyana.pdf |
| _version_ | 1848837861185421312 |
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| author | Nur Qistina Diyana, binti Khairul Anwar |
| author_facet | Nur Qistina Diyana, binti Khairul Anwar |
| author_sort | Nur Qistina Diyana, binti Khairul Anwar |
| building | UNIMAS Institutional Repository |
| collection | Online Access |
| description | Phthalates are most frequently used chemical in industries to make plasticizers and polymer
additive in gel capsules, cosmetic, and other personal care products. This study was initiated
to enhance our insight on the health and environmental impact on Dipropyl phthalate, DPP
- one of the phthalate family. In this study, the effects of dipropyl phthalate on the
development of zebrafish embryos and early larval stages were investigated. Eggs were
exposed to dipropyl phthalate toxic started from 4 to 96-hour post fertilization (hpf), and
defects of the zebrafish larvae examined at 96 hpf. Toxicological endpoints like mortality,
hatching delay, pericardial edema, yolk sac edema, non-inflated swim bladder, deformation
of the tail, blood island, and mobility were recorded. The LC5o calculated to be 7.546 mg/L.
These results suggest that dipropyl phthalate could induce a dose-dependent toxicity in
embryos, which hinders normal development. |
| first_indexed | 2025-11-15T06:46:23Z |
| format | Final Year Project Report / IMRAD |
| id | unimas-15471 |
| institution | Universiti Malaysia Sarawak |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T06:46:23Z |
| publishDate | 2016 |
| publisher | Universiti Malaysia Sarawak, (UNIMAS) |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | unimas-154712024-02-09T07:28:19Z http://ir.unimas.my/id/eprint/15471/ Toxicity screening analysis of dipropyl phthalate, DPP on early vertebrate development Nur Qistina Diyana, binti Khairul Anwar QD Chemistry Phthalates are most frequently used chemical in industries to make plasticizers and polymer additive in gel capsules, cosmetic, and other personal care products. This study was initiated to enhance our insight on the health and environmental impact on Dipropyl phthalate, DPP - one of the phthalate family. In this study, the effects of dipropyl phthalate on the development of zebrafish embryos and early larval stages were investigated. Eggs were exposed to dipropyl phthalate toxic started from 4 to 96-hour post fertilization (hpf), and defects of the zebrafish larvae examined at 96 hpf. Toxicological endpoints like mortality, hatching delay, pericardial edema, yolk sac edema, non-inflated swim bladder, deformation of the tail, blood island, and mobility were recorded. The LC5o calculated to be 7.546 mg/L. These results suggest that dipropyl phthalate could induce a dose-dependent toxicity in embryos, which hinders normal development. Universiti Malaysia Sarawak, (UNIMAS) 2016 Final Year Project Report / IMRAD NonPeerReviewed text en http://ir.unimas.my/id/eprint/15471/3/Nur%20Qistina%20Diyana.pdf Nur Qistina Diyana, binti Khairul Anwar (2016) Toxicity screening analysis of dipropyl phthalate, DPP on early vertebrate development. [Final Year Project Report / IMRAD] (Unpublished) |
| spellingShingle | QD Chemistry Nur Qistina Diyana, binti Khairul Anwar Toxicity screening analysis of dipropyl phthalate, DPP on early vertebrate development |
| title | Toxicity screening analysis of dipropyl phthalate, DPP on early vertebrate development |
| title_full | Toxicity screening analysis of dipropyl phthalate, DPP on early vertebrate development |
| title_fullStr | Toxicity screening analysis of dipropyl phthalate, DPP on early vertebrate development |
| title_full_unstemmed | Toxicity screening analysis of dipropyl phthalate, DPP on early vertebrate development |
| title_short | Toxicity screening analysis of dipropyl phthalate, DPP on early vertebrate development |
| title_sort | toxicity screening analysis of dipropyl phthalate, dpp on early vertebrate development |
| topic | QD Chemistry |
| url | http://ir.unimas.my/id/eprint/15471/ http://ir.unimas.my/id/eprint/15471/3/Nur%20Qistina%20Diyana.pdf |