Preparation and Characterization of Curcumin-loaded Cellulose Nanoparticles
Curcumin possesses diverse pharmacological activities such as anti-inflammatory, anti-carcinogenic and antioxidant but its uses are limited by its poor bioavailability and low water solubility. The objective of this study is to prepare curcumin loaded cellulose nanoparticles and to optimise the lo...
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| Format: | Final Year Project Report / IMRAD |
| Language: | English English |
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Universiti Malaysia Sarawak, (UNIMAS)
2015
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| Online Access: | http://ir.unimas.my/id/eprint/10423/ http://ir.unimas.my/id/eprint/10423/3/CHIU%20HOCK%20ING%2024pgs.pdf http://ir.unimas.my/id/eprint/10423/6/CHIU%20HOCK%20ING%20ft.pdf |
| _version_ | 1848836778541187072 |
|---|---|
| author | Chiu, Hock Ing |
| author_facet | Chiu, Hock Ing |
| author_sort | Chiu, Hock Ing |
| building | UNIMAS Institutional Repository |
| collection | Online Access |
| description | Curcumin possesses diverse pharmacological activities such as anti-inflammatory, anti-carcinogenic and
antioxidant but its uses are limited by its poor bioavailability and low water solubility. The objective of this
study is to prepare curcumin loaded cellulose nanoparticles and to optimise the loading efficiency and loading
capacity of curcumin in cellulose nanoparticles. Curcumin loaded cellulose nanoparticles with a mean size of
114 nm and size range of 73-263 nm in diameter were successfully regenerated by using in situ
nanoprecipitation technique. Different parameters such as ratio of cellulose solution to ethanolic curcumin
solution, concentration of ethanolic curcumin solution, concentration of surfactant (Tween 80), and loading
durations were controlled to examine the loading efficiency and loading capacity of curcumin in cellulose
nanoparticles. The UV-visible spectra showed a characteristic absorption peak at 470 nm. The functional
groups of chemical structure, morphology, and mean size of curcumin-loaded nanoparticles were characterized
by using FTIR, SEM and TEM. 2.38 mg/mg loading capacity and 30.57% loading efficiency of curcumin were
obtained using 1:6 (v/v) phase ratio with 0.1 mg/mL ethanolic curcumin solution within 1 hour loading. |
| first_indexed | 2025-11-15T06:29:10Z |
| format | Final Year Project Report / IMRAD |
| id | unimas-10423 |
| institution | Universiti Malaysia Sarawak |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T06:29:10Z |
| publishDate | 2015 |
| publisher | Universiti Malaysia Sarawak, (UNIMAS) |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | unimas-104232023-01-20T03:21:09Z http://ir.unimas.my/id/eprint/10423/ Preparation and Characterization of Curcumin-loaded Cellulose Nanoparticles Chiu, Hock Ing QD Chemistry Curcumin possesses diverse pharmacological activities such as anti-inflammatory, anti-carcinogenic and antioxidant but its uses are limited by its poor bioavailability and low water solubility. The objective of this study is to prepare curcumin loaded cellulose nanoparticles and to optimise the loading efficiency and loading capacity of curcumin in cellulose nanoparticles. Curcumin loaded cellulose nanoparticles with a mean size of 114 nm and size range of 73-263 nm in diameter were successfully regenerated by using in situ nanoprecipitation technique. Different parameters such as ratio of cellulose solution to ethanolic curcumin solution, concentration of ethanolic curcumin solution, concentration of surfactant (Tween 80), and loading durations were controlled to examine the loading efficiency and loading capacity of curcumin in cellulose nanoparticles. The UV-visible spectra showed a characteristic absorption peak at 470 nm. The functional groups of chemical structure, morphology, and mean size of curcumin-loaded nanoparticles were characterized by using FTIR, SEM and TEM. 2.38 mg/mg loading capacity and 30.57% loading efficiency of curcumin were obtained using 1:6 (v/v) phase ratio with 0.1 mg/mL ethanolic curcumin solution within 1 hour loading. Universiti Malaysia Sarawak, (UNIMAS) 2015 Final Year Project Report / IMRAD NonPeerReviewed text en http://ir.unimas.my/id/eprint/10423/3/CHIU%20HOCK%20ING%2024pgs.pdf text en http://ir.unimas.my/id/eprint/10423/6/CHIU%20HOCK%20ING%20ft.pdf Chiu, Hock Ing (2015) Preparation and Characterization of Curcumin-loaded Cellulose Nanoparticles. [Final Year Project Report / IMRAD] |
| spellingShingle | QD Chemistry Chiu, Hock Ing Preparation and Characterization of Curcumin-loaded Cellulose Nanoparticles |
| title | Preparation and Characterization of Curcumin-loaded Cellulose Nanoparticles |
| title_full | Preparation and Characterization of Curcumin-loaded Cellulose Nanoparticles |
| title_fullStr | Preparation and Characterization of Curcumin-loaded Cellulose Nanoparticles |
| title_full_unstemmed | Preparation and Characterization of Curcumin-loaded Cellulose Nanoparticles |
| title_short | Preparation and Characterization of Curcumin-loaded Cellulose Nanoparticles |
| title_sort | preparation and characterization of curcumin-loaded cellulose nanoparticles |
| topic | QD Chemistry |
| url | http://ir.unimas.my/id/eprint/10423/ http://ir.unimas.my/id/eprint/10423/3/CHIU%20HOCK%20ING%2024pgs.pdf http://ir.unimas.my/id/eprint/10423/6/CHIU%20HOCK%20ING%20ft.pdf |