Solid phase transformation of carbamazepine-succinic co-crystal
This paper presents the solid phase transformation of carbamazepine-succinic co-crystal. Solvent evaporation, slurry crystallization and cooling crystallization are the three techniques which represent the solution based method were used. In this study ethanol was used as solvent. CBZ-SUC co-crystal...
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| Format: | Undergraduates Project Papers |
| Language: | English |
| Published: |
2014
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| Subjects: | |
| Online Access: | http://umpir.ump.edu.my/id/eprint/9076/ http://umpir.ump.edu.my/id/eprint/9076/1/cd8668.pdf |
| _version_ | 1848818396968255488 |
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| author | Engku Nadia, Engku Mat Nasir |
| author_facet | Engku Nadia, Engku Mat Nasir |
| author_sort | Engku Nadia, Engku Mat Nasir |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | This paper presents the solid phase transformation of carbamazepine-succinic co-crystal. Solvent evaporation, slurry crystallization and cooling crystallization are the three techniques which represent the solution based method were used. In this study ethanol was used as solvent. CBZ-SUC co-crystals formations are studied by varying the mol ratio of CBZ and SUC. The CBZ-SUC co-crystals formation was characterized by using X-ray powder diffraction (XRPD), and optical microscopy. From the XRPD pattern profile, it shows that the co-crystals were formed for all the ratio of CBZ and SUC by the slurry crystallization and cooling crystallization. The results shows that the pattern profiles representing the co-crystal as no peak are develop with the raw material peak. The morphology of the co-crystals formation is needle-like co-crystals for cooling crystallization and solvent evaporation. The morphology of slurry crystallization is difficult to characterize due to agglomeration effects. Results from this research may be useful in pharmaceutical industry as the co-crystals are successfully formed. |
| first_indexed | 2025-11-15T01:37:00Z |
| format | Undergraduates Project Papers |
| id | ump-9076 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T01:37:00Z |
| publishDate | 2014 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | ump-90762015-10-22T01:11:07Z http://umpir.ump.edu.my/id/eprint/9076/ Solid phase transformation of carbamazepine-succinic co-crystal Engku Nadia, Engku Mat Nasir TP Chemical technology This paper presents the solid phase transformation of carbamazepine-succinic co-crystal. Solvent evaporation, slurry crystallization and cooling crystallization are the three techniques which represent the solution based method were used. In this study ethanol was used as solvent. CBZ-SUC co-crystals formations are studied by varying the mol ratio of CBZ and SUC. The CBZ-SUC co-crystals formation was characterized by using X-ray powder diffraction (XRPD), and optical microscopy. From the XRPD pattern profile, it shows that the co-crystals were formed for all the ratio of CBZ and SUC by the slurry crystallization and cooling crystallization. The results shows that the pattern profiles representing the co-crystal as no peak are develop with the raw material peak. The morphology of the co-crystals formation is needle-like co-crystals for cooling crystallization and solvent evaporation. The morphology of slurry crystallization is difficult to characterize due to agglomeration effects. Results from this research may be useful in pharmaceutical industry as the co-crystals are successfully formed. 2014-07 Undergraduates Project Papers NonPeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/9076/1/cd8668.pdf Engku Nadia, Engku Mat Nasir (2014) Solid phase transformation of carbamazepine-succinic co-crystal. Faculty of Chemical & Natural Resources Engineering, Universiti Malaysia Pahang. http://umpir.ump.edu.my/cgi/users/home?screen=EPrint::View&eprintid=9075#t |
| spellingShingle | TP Chemical technology Engku Nadia, Engku Mat Nasir Solid phase transformation of carbamazepine-succinic co-crystal |
| title | Solid phase transformation of carbamazepine-succinic co-crystal |
| title_full | Solid phase transformation of carbamazepine-succinic co-crystal |
| title_fullStr | Solid phase transformation of carbamazepine-succinic co-crystal |
| title_full_unstemmed | Solid phase transformation of carbamazepine-succinic co-crystal |
| title_short | Solid phase transformation of carbamazepine-succinic co-crystal |
| title_sort | solid phase transformation of carbamazepine-succinic co-crystal |
| topic | TP Chemical technology |
| url | http://umpir.ump.edu.my/id/eprint/9076/ http://umpir.ump.edu.my/id/eprint/9076/ http://umpir.ump.edu.my/id/eprint/9076/1/cd8668.pdf |