Identification of novel 5-lipoxygenase-activating protein (FLAP) inhibitors by an integrated method of pharmacophore virtual screening, docking, QSAR and ADMET analyses

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Identification of novel 5-lipoxygenase-activating protein (FLAP) inhibitors by an integrated method of pharmacophore virtual screening, docking, QSAR and ADMET analyses

This study explored a series of reported 5-lipoxygenase-activating protein (FLAP) inhibitors to understand their structural requirements and identify potential new inhibitor scaffolds through automated unbiased procedures. Docking studies have revealed that inhibitor binding affinity can be influenc...

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Bibliographic Details
Main Authors:	Rullah, Kamal, Roney, Miah, Zalikha, Ibrahim, Nur Farisya, Shamsudin, Deri, Islami, Qamar Uddin, Ahmed, Kok, Wai Lam, Mohd Fadhlizil Fasihi, Mohd Aluwi
Format:	Article
Language:	English
Published:	World Scientific Publishing 2023
Subjects:	Q Science (General) QD Chemistry TP Chemical technology
Online Access:	http://umpir.ump.edu.my/id/eprint/40039/ http://umpir.ump.edu.my/id/eprint/40039/1/Identification%20of%20novel%205-lipoxygenase-activating%20protein_abst.pdf

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