Identification of novel 5-lipoxygenase-activating protein (FLAP) inhibitors by an integrated method of pharmacophore virtual screening, docking, QSAR and ADMET analyses

Identification of novel 5-lipoxygenase-activating protein (FLAP) inhibitors by an integrated method of pharmacophore virtual screening, docking, QSAR and ADMET analyses

This study explored a series of reported 5-lipoxygenase-activating protein (FLAP) inhibitors to understand their structural requirements and identify potential new inhibitor scaffolds through automated unbiased procedures. Docking studies have revealed that inhibitor binding affinity can be influenc...

Full description

Bibliographic Details
Main Authors: Rullah, Kamal, Roney, Miah, Zalikha, Ibrahim, Nur Farisya, Shamsudin, Deri, Islami, Qamar Uddin, Ahmed, Kok, Wai Lam, Mohd Fadhlizil Fasihi, Mohd Aluwi
Format: Article
Language:English
Published: World Scientific Publishing 2023
Subjects:
Q Science (General)
QD Chemistry
TP Chemical technology
Online Access:http://umpir.ump.edu.my/id/eprint/40039/
http://umpir.ump.edu.my/id/eprint/40039/1/Identification%20of%20novel%205-lipoxygenase-activating%20protein_abst.pdf

Internet

http://umpir.ump.edu.my/id/eprint/40039/
http://umpir.ump.edu.my/id/eprint/40039/1/Identification%20of%20novel%205-lipoxygenase-activating%20protein_abst.pdf

Similar Items