Andrographis paniculata (Burm. f.) wall. ex nees: An updated review of phytochemistry, antimicrobial pharmacology, and clinical safety and efficacy
Infectious disease (ID) is one of the top-most serious threats to human health globally, further aggravated by antimicrobial resistance and lack of novel immunization options. Andrographis paniculata (Burm. f.) Wall. ex Nees and its metabolites have been long used to treat IDs. Andrographolide, deri...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021
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| Online Access: | http://umpir.ump.edu.my/id/eprint/32771/ http://umpir.ump.edu.my/id/eprint/32771/1/Andrographis%20paniculata%20%28Burm.%20f.%29%20wall.%20ex%20nees_An%20updated%20review%20of%20phytochemistry%2C%20antimicrobial%20pharmacology.pdf |
| _version_ | 1848824106307289088 |
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| author | Hossain, Sanower Urbi, Zannat Hidayah, Karuniawati Ramisa, Mohiuddin Qrimida, Ahmed Moh Mohamed Masaud Allzrag, Akrm Ming, Long Chiau Pagano, Ester Capasso, Raffaele |
| author_facet | Hossain, Sanower Urbi, Zannat Hidayah, Karuniawati Ramisa, Mohiuddin Qrimida, Ahmed Moh Mohamed Masaud Allzrag, Akrm Ming, Long Chiau Pagano, Ester Capasso, Raffaele |
| author_sort | Hossain, Sanower |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | Infectious disease (ID) is one of the top-most serious threats to human health globally, further aggravated by antimicrobial resistance and lack of novel immunization options. Andrographis paniculata (Burm. f.) Wall. ex Nees and its metabolites have been long used to treat IDs. Andrographolide, derived from A. paniculata, can inhibit invasive microbes virulence factors and regulate the host immunity. Controlled clinical trials revealed that A. paniculata treatment is safe and efficacious for acute respiratory tract infections like common cold and sinusitis. Hence, A. paniculata, mainly andrographolide, could be considered as an excellent candidate for antimicrobial drug development. Considering the importance, medicinal values, and significant role as antimicrobial agents, this study critically evaluated the antimicrobial therapeutic potency of A. paniculata and its metabolites, focusing on the mechanism of action in inhibiting invasive microbes and biofilm formation. A critical evaluation of the secondary metabolites with the aim of identifying pure compounds that possess antimicrobial functions has further added significant values to this study. Notwithstanding that A. paniculata is a promising source of antimicrobial agents and safe treatment for IDs, further empirical research is warranted. |
| first_indexed | 2025-11-15T03:07:45Z |
| format | Article |
| id | ump-32771 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T03:07:45Z |
| publishDate | 2021 |
| publisher | MDPI AG |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | ump-327712022-03-08T05:06:47Z http://umpir.ump.edu.my/id/eprint/32771/ Andrographis paniculata (Burm. f.) wall. ex nees: An updated review of phytochemistry, antimicrobial pharmacology, and clinical safety and efficacy Hossain, Sanower Urbi, Zannat Hidayah, Karuniawati Ramisa, Mohiuddin Qrimida, Ahmed Moh Mohamed Masaud Allzrag, Akrm Ming, Long Chiau Pagano, Ester Capasso, Raffaele TP Chemical technology Infectious disease (ID) is one of the top-most serious threats to human health globally, further aggravated by antimicrobial resistance and lack of novel immunization options. Andrographis paniculata (Burm. f.) Wall. ex Nees and its metabolites have been long used to treat IDs. Andrographolide, derived from A. paniculata, can inhibit invasive microbes virulence factors and regulate the host immunity. Controlled clinical trials revealed that A. paniculata treatment is safe and efficacious for acute respiratory tract infections like common cold and sinusitis. Hence, A. paniculata, mainly andrographolide, could be considered as an excellent candidate for antimicrobial drug development. Considering the importance, medicinal values, and significant role as antimicrobial agents, this study critically evaluated the antimicrobial therapeutic potency of A. paniculata and its metabolites, focusing on the mechanism of action in inhibiting invasive microbes and biofilm formation. A critical evaluation of the secondary metabolites with the aim of identifying pure compounds that possess antimicrobial functions has further added significant values to this study. Notwithstanding that A. paniculata is a promising source of antimicrobial agents and safe treatment for IDs, further empirical research is warranted. MDPI AG 2021-04-16 Article PeerReviewed pdf en cc_by_4 http://umpir.ump.edu.my/id/eprint/32771/1/Andrographis%20paniculata%20%28Burm.%20f.%29%20wall.%20ex%20nees_An%20updated%20review%20of%20phytochemistry%2C%20antimicrobial%20pharmacology.pdf Hossain, Sanower and Urbi, Zannat and Hidayah, Karuniawati and Ramisa, Mohiuddin and Qrimida, Ahmed Moh and Mohamed Masaud Allzrag, Akrm and Ming, Long Chiau and Pagano, Ester and Capasso, Raffaele (2021) Andrographis paniculata (Burm. f.) wall. ex nees: An updated review of phytochemistry, antimicrobial pharmacology, and clinical safety and efficacy. Life, 11 (4). pp. 1-39. ISSN 2075-1729. (Published) https://doi.org/10.3390/life11040348 https://doi.org/10.3390/life11040348 |
| spellingShingle | TP Chemical technology Hossain, Sanower Urbi, Zannat Hidayah, Karuniawati Ramisa, Mohiuddin Qrimida, Ahmed Moh Mohamed Masaud Allzrag, Akrm Ming, Long Chiau Pagano, Ester Capasso, Raffaele Andrographis paniculata (Burm. f.) wall. ex nees: An updated review of phytochemistry, antimicrobial pharmacology, and clinical safety and efficacy |
| title | Andrographis paniculata (Burm. f.) wall. ex nees: An updated review of phytochemistry, antimicrobial pharmacology, and clinical safety and efficacy |
| title_full | Andrographis paniculata (Burm. f.) wall. ex nees: An updated review of phytochemistry, antimicrobial pharmacology, and clinical safety and efficacy |
| title_fullStr | Andrographis paniculata (Burm. f.) wall. ex nees: An updated review of phytochemistry, antimicrobial pharmacology, and clinical safety and efficacy |
| title_full_unstemmed | Andrographis paniculata (Burm. f.) wall. ex nees: An updated review of phytochemistry, antimicrobial pharmacology, and clinical safety and efficacy |
| title_short | Andrographis paniculata (Burm. f.) wall. ex nees: An updated review of phytochemistry, antimicrobial pharmacology, and clinical safety and efficacy |
| title_sort | andrographis paniculata (burm. f.) wall. ex nees: an updated review of phytochemistry, antimicrobial pharmacology, and clinical safety and efficacy |
| topic | TP Chemical technology |
| url | http://umpir.ump.edu.my/id/eprint/32771/ http://umpir.ump.edu.my/id/eprint/32771/ http://umpir.ump.edu.my/id/eprint/32771/ http://umpir.ump.edu.my/id/eprint/32771/1/Andrographis%20paniculata%20%28Burm.%20f.%29%20wall.%20ex%20nees_An%20updated%20review%20of%20phytochemistry%2C%20antimicrobial%20pharmacology.pdf |